高速切削振动的形成及其控制

基于系统工程理论,阐述了高速机床结构、工具系统构成、工件材料特性、切削参数选用和加工环境状况是导致高速切削加工振动形成的主要原因。探讨了高速加工振动形成的机制,并针对高速加工系统各部位控制的特点,提出了主动控制高速加工振动的主要控制策略及改进途径。     

LD端面抽运激光介质热效应的有限元分析

针对激光介质的通光面为方形、抽运光为高斯光束的情况,以Nd:YAG激光介质为例,用ANSYS有限元软件模拟了激光介质的热效应,精确地给出了激光介质中各点的温度和温度分布。分别对提高介质侧面对流换热系数、降低冷却液温度、抽运端面水冷这3种情况下的温度场进行了模拟。结果表明,通过提高晶体侧面的热对流换热系数和降低冷却液温度,几乎不能降低激光介质的热效应,而通过抽运端面水冷,可有效地降低激光介质的热效应。     

In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model

There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line INS-1E and dispersed mouse islet cells to assess the effects of endocrine disruptors on cell viability and glucose-stimulated insulin secretion (GSIS). We tested six chemicals at concentrations within human exposure (from 0.1 pM to 1 µM). Bisphenol-A (BPA) and tributyltin (TBT) were used as controls while four other chemicals, namely perfluorooctanoic acid (PFOA), triphenylphosphate (TPP), triclosan (TCS) and dichlorodiphenyldichloroethylene (DDE), were used as “unknowns”. Regarding cell viability, BPA and TBT increased cell death as previously observed. Their mode of action involved the activation of estrogen receptors and PPARγ, respectively. ROS production was a consistent key event in BPA-and TBT-treated cells. None of the other MDCs tested modified viability or ROS production. Concerning GSIS, TBT increased insulin secretion while BPA produced no effects. PFOA decreased GSIS, suggesting that this chemical could be a “new” diabetogenic agent. Our results indicate that the EndoC-βH1 cell line is a suitable human β-cell model for testing diabetogenic MDCs. Optimization of the test methods proposed here could be incorporated into a set of protocols for the identification of MDCs.     

关于异黄酮类化合物精制方法的探讨

简单介绍了异黄酮类化合物的结构、性质,着重对吸附法、超滤膜法、溶剂提取（萃取）法、色谱法、重结晶法等异黄酮精制方法的特点和应用情况进行了综述。     

A cluster-DEE-based strategy to empower protein design

The Medical and Pharmaceutical industries have shown high interest in the precise engineering of protein hormones and enzymes that perform existing functions under a wide range of conditions. Proteins are responsible for the execution of different functions in the cell: catalysis in chemical reactions, transport and storage, regulation and recognition control. Computational Protein Design (CPD) investigates the relationship between 3-D structures of proteins and amino acid sequences and looks for all sequences that will fold into such 3-D structure. Many computational methods and algorithms have been proposed over the last years, but the problem still remains a challenge for Mathematicians, Computer Scientists, Bioinformaticians and Structural Biologists. In this article we present a new method for the protein design problem. Clustering techniques and a Dead-End-Elimination algorithm are combined with a SAT problem representation of the CPD problem in order to design the amino acid sequences. The obtained results illustrate the accuracy of the proposed method, suggesting that integrated Artificial Intelligence techniques are useful tools to solve such an intricate problem.     

检定S型短型热电偶的4种不同冷端补偿方法之比较

检定长度在200～700 mm范围内的S型热电偶时,由于参考端温度大都处于室温或者波动的温场之中,需要将参考端温度恒定在0℃或采取修正、补偿等措施进行修正。现采取检定中最常用的4种不同的冷端补偿方法检定同一支S型短型热电偶,对结果进行比较分析,得到这4种不同的冷端补偿方法的优劣性及其准确度排序。结果表明,将参考端应用达到一等标准热电偶准确度水平的同极性热电偶丝延伸至参考端恒温器方法能获得较为理想的补偿效果。     

A statistical micromechanical model of multiple cracking for ultra high toughness cementitious composites

A new statistical micromechanical model of multiple cracking is proposed in which a general expression of the fiber bridging stress laws in the crack plane is established. In this model, the random distribution properties of fibers are considered. And the Weibull function is adopted to represent the flaw size distribution. The relationships of stress versus strain and crack width versus strain are proposed. The formulas of the crack width, crack space, strain capacity and fracture energy density at the end of multiple cracking processes are also deduced. The validity of the proposed model was demonstrated by experimental results.     

Introducing concurrency in sequential Java via laws

Nowadays multi-core processors can be found everywhere. It is well known that one way of improving performance is by parallelization. In this paper we propose a parallelization strategy for Java using algebraic laws. We perform an experiment with two benchmarks and show that our strategy produces a gain similar to a specialized parallel version provided by the Java Grande Benchmark (JGB).     

基层设备管理中的专业考核问题

在基层设备管理中,建立以案例考核为主体的考核体系,采用多种激励手段,实现设备管理的有效性和经济性。     

Mass balance soil ingestion estimating methods and their application to inhabitants of rural and wilderness areas: A critical review

Quantitative soil ingestion studies employing a mass balance tracer approach have been used to provide a defensible means to estimate soil ingestion for human health risk assessments. Past studies have focused on soil ingestion in populations living in urban/suburban environments. There is a paucity of reliable quantitative soil ingestion data to support human health risk assessments of other lifestyles that may be predisposed to ingesting soil, such as agricultural workers or indigenous populations following traditional lifestyles. The results of a preliminary analysis of sampling and analytical variability that would result from assessing activities typical of populations in rural or wilderness areas and conducted over wide areas show that approximately 225 subject days would be required to detect a difference of 20 mg/d in soil ingestion. Given the typically small populations in these areas, future soil ingestion studies should be focused on specific activities with a high potential for soil ingestion.