Staphylococcus aureus—A Known Opponent against Host Defense Mechanisms and Vaccine Development—Do We Still Have a Chance to Win?

The main purpose of this review is to present justification for the urgent need to implement specific prophylaxis of invasive Staphylococcus aureus infections. We emphasize the difficulties in achieving this goal due to numerous S. aureus virulence factors important for the process of infection and the remarkable ability of these bacteria to avoid host defense mechanisms. We precede these considerations with a brief overview of the global necessitiy to intensify the use of vaccines against other pathogens as well, particularly in light of an impasse in antibiotic therapy. Finally, we point out global trends in research into modern technologies used in the field of molecular microbiology to develop new vaccines. We focus on the vaccines designed to fight the infections caused by S. aureus, which are often resistant to the majority of available therapeutic options.     

京津唐电网一次调频投入现状及存在问题分析

结合2005年10月25日托克托电厂机组全停事故发生后,华北电网频率的变化和各机组一次调频的负荷响应情况,对并网机组一次调频能力进行了评价,指出了目前京津唐电网机组一次调频投入存在的问题、改进要求与建议。     

粘滞阻尼器对高层钢结构抗震性能的影响分析

介绍了粘滞阻尼器优良的耗能性能,以及在高层建筑中的应用情况。通过北京某高层钢结构分析实例,以通用有限元软件ANSYS建立计算模型,采用时程计算方法,探讨了未控和受控结构在地震作用下的抗震性能。结果表明,粘滞阻尼器能有效地消耗地震输入能,减小结构地震响应。     

框架复合隔震结构地震响应分析

以某六层框架复合隔震结构为例,运用有限元分析程序,对一般抗震结构、纯夹层橡胶隔震结构和复合隔震结构三种方案进行了地震作用下的动力响应分析,从分析结果得出纯橡胶隔震结构和复合隔震结构有明显的隔震、减震效果。复合隔震结构从结构的造价和抗震安全度更能体现其优越性,这对复合隔震结构的设计和分析有一定的意义。     

Fundamental Clock of Biological Aging: Convergence of Molecular,Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

In humans, age-associated degrading changes, widely observed in molecular and cellular processes underly the time-dependent decline in spatial navigation, time perception, cognitive and psychological abilities, and memory. Cross-talk of biological, cognitive, and psychological clocks provides an integrative contribution to healthy and advanced aging. At the molecular level, genome, proteome, and lipidome instability are widely recognized as the primary causal factors in aging. We narrow attention to the roles of protein aging linked to prevalent amino acids chirality, enzymatic and spontaneous (non-enzymatic) post-translational modifications (PTMs ^SP), and non-equilibrium phase transitions. The homochirality of protein synthesis, resulting in the steady-state non-equilibrium condition of protein structure, makes them prone to multiple types of enzymatic and spontaneous PTMs, including racemization and isomerization. Spontaneous racemization leads to the loss of the balanced prevalent chirality. Advanced biological aging related to irreversible PTMs ^SP has been associated with the nontrivial interplay between somatic (molecular aging) and mental (psychological aging) health conditions. Through stress response systems (SRS), the environmental and psychological stressors contribute to the age-associated “collapse” of protein homochirality. The role of prevalent protein chirality and entropy of protein folding in biological aging is mainly overlooked. In a more generalized context, the time-dependent shift from enzymatic to the non-enzymatic transformation of biochirality might represent an important and yet underappreciated hallmark of aging. We provide the experimental arguments in support of the racemization theory of aging.     

轨道-箱梁结构振动传递的模型试验研究

以京沪高铁常用的32 m无砟轨道箱梁结构为原型进行了模型试验,其中模型为轨道-箱梁结构.根据1/10的几何相似比,介绍了试验模型各结构的设计与制作过程,荷载激励由激振器施加.试验结果表明:轨道板振动在500-1024 Hz频段内衰减缓慢,底座板和顶板振动在0-1024 Hz频段内衰减较快;振动由顶板传递至翼缘板的过程中...     

基于响应面分析法的粮食搬运RGV抓手优化设计

取货抓手是粮食搬运RGV完成存取货任务的重要组成部件,由于承载较重,抓手极易发生疲劳和变形.传统的设计方法主要靠实际经验确定抓手的关键尺寸,设计周期长、可靠性低.基于ANSYS软件并采用响应面分析法对抓手进行尺寸优化设计,以抓手的关键尺寸为设计变量,以降低最大等效应力、减小整体变形为优化目标,分析尺寸参数与优化参数之间...     

基于频偏应答的ADCP流速现场校准方法研究

针对声学多普勒流速剖面仪(ADCP)现场校准困难的问题,介绍了一种基于频偏应答的ADCP流速现场校准方法.通过声信号应答器,设置回发信号相对于发射信号的频偏实现速度矢量的模拟,并以频率为溯源量,对ADCP发射的信号及应答器回发频偏信号进行频率校准,进而实现ADCP流速参数的现场校准.研制了一套基于频偏应答的ADCP流速...     

单球多位置灵敏计数器的中子能量响应合理性初步探索

设计了一种单球3个位置灵敏计数器不同分区方法,借用蒙特卡罗模拟对5个计数区的中子能量响应进行了计算,并分析5个计数区的能量响应合理性.基于能量响应假设实验,利用少道解谱UMG软件包对诸如注量和周围剂量当量的剂量学量进行计算,并对计算的结果进行了讨论.设计了一种单球3个位置灵敏计数器不同分区方法,借用蒙特卡罗模拟对5个计数区的中子能量响应进行了计算,并分析5个计数区的能量响应合理性.基于能量响应假设实验,利用少道解谱UMG软件包对诸如注量和周围剂量当量的剂量学量进行计算,并对计算的结果进行了讨论.     

非弹性反应谱衰减规律研究

为研究非弹性反应谱的特征,选用美国西部Californ ia州15次较大地震中的266条强地震动记录,建立了非弹性反应谱衰减规律.分析了场地条件、延性系数、震级及距离等参数对非弹性反应谱的影响.研究发现,随着场地变软或震级增大,非弹性反应谱增大;随着延性系数增加,非弹性反应谱降低,但延性系数增加到一定程度,谱值变化不大;随着距离增加,每个周期的非弹性反应谱值衰减很快.