新构造活动对松辽盆地含油气系统的影响

通过对新构造活动的研究以辽盆地第三系地层构造变表的椭球体应变分析，发现在老第三系地层沉积中晚期，挤压应力方向发展了由南北到近东西向的变化；表现出地层分布局限、充填碎屑粗、隆起剥蚀区可作为物源区等特点；明末后的压陷盆地沉积过程，为松辽盆地中浅层形成构造并不断壮大的过程，为油气的聚集提供了良好的圈闭，压陷盆地的沉积为中浅层生烃高峰期也有利于油气的保存，挤压力方向的改变导致了中浅层不同方向的老断层开启，开辟了多方位的油气运移的通道；进而实现了油气的生成、运移、聚集和保存的良好匹配。     

改变润湿消除钻头泥包钻井液技术研究

钻井过程中钻屑颗粒吸附钻头、BHA面形成泥包导致重复破碎,严重影响钻井速度。为此,提出改变润湿钻井液需具备功能及处理剂分子结构要求,研发了改变润湿防止钻头泥包剂(KSZJ-1)。通过润湿性、表面张力、吸附效应等试验对改变润湿防止钻头泥包剂的润湿性和改善钻头泥包的性能进行了评价,试验结果表明,KSZJ-1一方面在钻屑表面形成单分子吸附层防止钻屑附聚造成重复切削;另一方面改变岩石表面及孔隙内部的润湿性,降低岩石的表面张力;而且在钻头、BHA面以有机膦定向吸附的形式形成强定向多分子层物理和化学吸附,显著减少钻头泥包的现象。     

4H-SiC肖特基微型同位素电池(英文)

半导体同位素电池由于其寿命长、集成性优良、环境适应性强等特点成为解决MEMS能源问题的理想手段。利用4H-SiC材料的宽禁带特性,制造了4H-SiC肖特基同位素电池。对电池的耗尽层厚度以及掺杂浓度进行了优化设计,对肖特基金属进行了选择。使用4mCi/cm2的63Ni作为同位素电池的放射源对制造的同位素电池进行了测试。测试结果表明,该同位素电池可以获得31.3nW/cm2的功率密度、0.5V的开路电压、3.13×10-8A/cm2的短路电流密度和1.3%的转换效率。将电池的输出特性和硅基的平板型、3D结构电池输出特性进行了比较,证明4H-SiC肖特基同位素电池能够获得较高的功率密度。电池的性能可通过提升势垒高度、提高工艺质量、更换同位素等方式得到提高。     

PROPERTIES OF W/Cu FGMS CONTAINING 1%TiC OR 1%La2O3 PREPARED USING GSUHP

W / Cu functionally gradient materials (FGMs) containing 1%La_2O_3 and 1%TiC were prepared using graded sintering under ultra-high pressure (GSUHP). The specimens have been found to exhibit low porosity (11.57% and 11.35%, respectively). Shearing strength of the specimens between layers is good. Moreover, the specimens have still demonstrated good performance in testing thermal-shock resistance. When power density of laser is 200MWm~(-2), the specimens have been tested for thermal-shock resistance (1000 times); the specimens that contained 1%La_2O_3 were not subjected to damage, whereas those that contained 1%TiC began to crack. Finally, effect of additives on thermal-shock resistance was also preliminarily discussed.     

Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis

Non-alcoholic steatohepatitis (NASH) has pathological characteristics similar to those of alcoholic hepatitis, despite the absence of a drinking history. The greatest threat associated with NASH is its progression to cirrhosis and hepatocellular carcinoma. The pathophysiology of NASH is not fully understood to date. In this study, we investigated the pathophysiology of NASH from the perspective of glycolysis and the Warburg effect, with a particular focus on microRNA regulation in liver-specific macrophages, also known as Kupffer cells. We established NASH rat and mouse models and evaluated various parameters including the liver-to-body weight ratio, blood indexes, and histopathology. A quantitative phosphoproteomic analysis of the NASH rat model livers revealed the activation of glycolysis. Western blotting and immunohistochemistry results indicated that the expression of pyruvate kinase muscle 2 (PKM2), a rate-limiting enzyme of glycolysis, was upregulated in the liver tissues of both NASH models. Moreover, increases in PKM2 and p-PKM2 were observed in the early phase of NASH. These observations were partially induced by the downregulation of microRNA122-5p (miR-122-5p) and occurred particularly in the Kupffer cells. Our results suggest that the activation of glycolysis in Kupffer cells during NASH was partially induced by the upregulation of PKM2 via miR-122-5p suppression.     

一种粘滞阻尼体系阻尼矩阵识别新方法

由不同材料组成的混合结构,其阻尼矩阵不再满足与质量矩阵、刚度矩阵的比例关系,具有非比例特性。我国设计规范中常用的振型分解反应谱法是基于比例阻尼建立的,并不严格适用于计算非比例阻尼体系的地震作用效应。该文在基于等效黏性阻尼模型的复模态叠加法基础上,结合虚拟激励法和平稳随机理论,推导了基于等效黏性阻尼模型的反应谱CCQC(Complex Complete Quadratic Combination)法实数表达式,建立了一种解决非比例阻尼混合结构的地震作用效应计算问题的理论方法。算例分析表明：与基于分块Rayleigh阻尼模型的反应谱CCQC法相比,该文建立的基于等效黏性阻尼模型的反应谱CCQC法直接依赖于结构的质量、刚度和阻尼参数,不受振型组合的影响,具有计算结果唯一的优点,且仅涉及位移相关系数的计算;与基于能量法的反应谱CQC法相比,基于等效黏性阻尼模型的反应谱CCQC法可有效考虑结构的非比例特性,适用于非比例特性较强的混合结构。     

环江油田巴19区块长7段钙夹层评价与大斜度井分段压裂优化

为实现最大化油藏接触,提高油藏产出水平,长庆环江油田巴19区块长7油藏采用大斜度井开发方式。在初期压裂改造中,由于忽视了层内钙质夹层对压裂缝高的影响,导致实际裂缝的几何形态与设计产生巨大偏差,出现了邻井裂缝串通及生产高含水等问题。本文通过研究油藏剖面测井特征,在细分层位基础上分析纵向应力分布,研究“复合层效应”影响裂缝缝高延伸的关键因素,优化了分段压裂方案,获得了更好的水力裂缝几何形态和尺寸。技术调整后现场压裂工艺质量获得提高,长7段油藏压裂改造质量优良率100%,大大提高了该区块的开发水平。     

低透气性煤层高压水力压裂—冲孔联合增透技术研究及应用

针对深部开采煤层普遍存在的构造应力复杂、透气性系数低、抽采效果差等问题,为探究最优的瓦斯抽采技术方案,以水溪煤矿K₁松软煤层为研究对象,分别采用水力压裂、水力冲孔、普通抽采和高压水力压裂—冲孔联合增透4种技术,进行现场对比应用试验。结果表明：高压水力压裂—冲孔联合增透技术对煤层透气性系数的提高程度分别为水力压裂、水力冲孔和普通抽采方案的1.85、1.61、6.30倍,抽采瓦斯纯流量分别提高了1.42、1.33、2.32倍,此外,抽采汇总瓦斯浓度(CH₄体积分数)保持在42.6%以上,抽采效率为四者之中最高。现场应用结果表明,高压水力压裂—冲孔联合增透技术具有明显的技术优势。