基于ARM的广播发射机微控制器硬件系统设计

应用Samsung公司的S3C44B0X嵌入式芯片构建硬件平台,设计广播发射机微控制器。按照其在广播发射机监测控制系统中的控制特点,介绍和论述该微控制器的硬件结构。与传统的基于8/16位单片机构建的系统相比,由于S3C44B0X芯片内置多种实用外设可大大简化电路,从而提高了系统的可靠性,增强了系统抗干扰能力。     

计算机无线网络技术若干问题的探讨

概述了计算机无线网络的特点及其应用方向。对IEEE(institute of electrical and electronics engineers)制定的无线网络标准802．11x系列采用的关键技术和相互兼容性进行对比和分析。针对无线网络的WEP(wired equivalent privacy)加密漏洞，综合比较分析主要的网络公司采用的安全机制，如有线等效保密的改进方案(WEP2)、端口访问控制(802．1x Port Access Control for WLANs)、动态安全链路(DSL，dynamic security link)和虚拟专用网(VPN，virtual private network)等。     

Effect of deteriorated microstructures on stress corrosion cracking of X70 pipeline steel in acidic soil environment

In order to investigate stress corrosion cracking (SCC) of X70 pipeline steel and its weld joint area in acidic soil environ-ment in China, two simulating methods were used: one was to obtain bad microstructures in heat affected zone by annealing at 1300°C for 10 min and then, quenching in water; the other was to get different simulating solutions of acidic soil in Yingtan in south-east China. The SCC susceptibilities of X70 pipeline steel before and after quenching in the simulating solutions were analyzed...     

多种金属氧化物混合物的固溶体的穆斯堡尔效应及XRD分析研究

在αFe_2O_3中依次累积加入K_2O、Cr_2O_3、CuO、MGO和SiO_2形成不同混合物,在空气中800℃活化焙烧5h后,发现αFe_2O_3和所加氧化物之间发生了不同的反应,生成不同的化合物。该结果有助于进一步理解这些氧化物作为助剂和载体的作用。     

双能X线吸收法与近红外法测定脂肪含量的评价

用美国Ｌｕｎａｒ ＤＰＸ－Ｌ骨密度仪和日本ＦＶＴＲＥＸ－１０００型近红外仪对９２例人群进行脂肪含量评价。其中７８例为健康人，男性４３例，女性３５例。测定结果女性平均脂肪含量高于男性，两种方法对全部人群的体脂肪测定结果相关系数ｒ＝０．９２１，本文介绍测定原理并对两种方法的优缺点作了评价。     

The P2X4 Receptor: Cellular and Molecular Characteristics of a Promising Neuroinflammatory Target

The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in neuroinflammatory disorders, but the ability to effectively target these receptors in models of neuroinflammation has presented a constant challenge. As such, the exact role of P2X4 receptors and their cell signalling mechanisms in human physiology and pathophysiology still requires further elucidation. To this end, research into the molecular mechanisms of P2X4 receptor activation, modulation, and inhibition has continued to gain momentum in an attempt to further describe the role of P2X4 receptors in neuroinflammation and other disease settings. Here we provide an overview of the current understanding of the P2X4 receptor, including its expression and function in cells involved in neuroinflammatory signalling. We discuss the pharmacology of P2X4 receptors and provide an overview of P2X4-targeting molecules, including agonists, positive allosteric modulators, and antagonists. Finally, we discuss the use of P2X4 receptor modulators and antagonists in models of neuroinflammatory cell signalling and disease.     

30.4 nm Si/C多层膜反射镜的制备与测量

采用离子束溅射镀膜装置制备了一种新的材料组合Si/C多层膜 ,用于 30 4nm波段的正入射多层膜反射镜。并用软X射线反射率计测得其反射比最大值为 0 14。有效地抑制了 15 0nm处的二级衍射峰。     

The P2X7R-NLRP3 and AIM2 Inflammasome Platforms Mark the Complexity/Severity of Viral or Metabolic Liver Damage

P2X7R-NLRP3 and AIM2 inflammasomes activate caspase-1 and the release of cytokines involved in viral-related liver disease. Little is known about their role in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steato-hepatitis (NASH). We characterized the role of inflammasomes in NAFLD, NASH, and HCV. Gene expression and subcellular localization of P2X7R/P2X4R-NLRP3 and AIM2 inflammasome components were examined in histopathological preparations of 46 patients with biopsy-proven viral and metabolic liver disease using real-time PCR and immunofluorescence. P2X7R, P2X4R, and Caspase-1 are two- to five-fold more expressed in patients with NAFLD/NASH associated with chronic HCV infection than those with metabolic damage only (p ≤ 0.01 for all comparisons). The AIM2 inflammasome is 4.4 times more expressed in patients with chronic HCV infection, regardless of coexistent metabolic abnormalities (p = 0.0006). IL-2, a cytokine playing a pivotal role during chronic HCV infection, showed a similar expression in HCV and NASH patients (p = 0.77) but was virtually absent in NAFLD. The P2X7R-NLRP3 complex prevailed in infiltrating macrophages, while AIM2 was localized in Kupffer cells. Caspase-1 expression correlated with elastography-based liver fibrosis (r = 0.35, p = 0.02), whereas P2X7R, P2X4R, NRLP3, Caspase-1, and IL-2 expression correlated with circulating markers of disease severity. P2X7R and P2X4R play a major role in liver inflammation accompanying chronic HCV infection, especially when combined with metabolic damage, while AIM2 is specifically expressed in chronic viral hepatitis. We describe for the first time the hepatic expression of IL-2 in NASH, so far considered a peculiarity of HCV-related liver damage.     

基于单片机的切纸机位移测量系统

介绍了一种基于单片机的切纸机位移测量系统。该系统以AT89C2051单片机为核心,实现了对切纸机刀具位置、进刀量以及进刀次数的实时测量,完成了多位测量结果的快速显示和测量结果的掉电保护。该系统测量准确、使用方便,大大提高了切纸机位移测量的精确度和工人的工作效率。     

NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats

Pannexin 1 (Panx1) is involved in the spinal central sensitization process in rats with neuropathic pain, but its interaction with well-known, pain-related, ligand-dependent receptors, such as NMDA receptors (NMDAR) and P2X7 purinoceptors (P2X7R), remains largely unexplored. Here, we studied whether NMDAR- and P2X7R-dependent nociceptive signaling in neuropathic rats require the activation of Panx1 channels to generate spinal central sensitization, as assessed by behavioral (mechanical hyperalgesia) and electrophysiological (C-reflex wind-up potentiation) indexes. Administration of either a selective NMDAR agonist i.t. (NMDA, 2 mM) or a P2X7R agonist (BzATP, 150 μM) significantly increased both the mechanical hyperalgesia and the C-reflex wind-up potentiation, effects that were rapidly reversed (minutes) by i.t. administration of a selective pannexin 1 antagonist (10panx peptide, 300 μM), with the scores even reaching values of rats without neuropathy. Accordingly, 300 μM 10panx completely prevented the effects of NMDA and BzATP administered 1 h later, on mechanical hyperalgesia and C-reflex wind-up potentiation. Confocal immunofluorescence imaging revealed coexpression of Panx1 with NeuN protein in intrinsic dorsal horn neurons of neuropathic rats. The results indicate that both NMDAR- and P2X7R-mediated increases in mechanical hyperalgesia and C-reflex wind-up potentiation require neuronal Panx1 channel activation to initiate and maintain nociceptive signaling in neuropathic rats.