汽车荷载作用下桥梁冲击系数影响规律研究

以三跨连续箱梁桥为研究对象,建立了桥梁模型和车辆模型从而组成车桥耦合动力模型,并对车辆荷载作用下桥梁结构的冲击系数进行研究分析。研究表明:增加横向车道数可以使桥梁的冲击系数增大,纵向距离越大桥梁冲击系数越小;车辆在制动状态下的桥梁冲击系数明显大于车辆匀速状态时的冲击系数,并且车辆在桥梁中跨前半部分制动时,动力冲击系数要大于后半跨;车辆在跳车冲击作用下,桥梁跨中冲击系数明显增大,且在跨中跳车时,桥梁动力冲击系数为最大。     

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies

α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA gene cause hereditary Parkinson’s disease. Highly phosphorylated and abnormally aggregated α-synuclein is a major component of Lewy bodies found in neuronal cells of patients with sporadic Parkinson’s disease, dementia with Lewy bodies, and glial cytoplasmic inclusion bodies in oligodendrocytes with multiple system atrophy. Aggregated α-synuclein is cytotoxic and plays a central role in the pathogenesis of the above-mentioned synucleinopathies. In a healthy brain, most α-synuclein is unphosphorylated; however, more than 90% of abnormally aggregated α-synuclein in Lewy bodies of patients with Parkinson’s disease is phosphorylated at Ser129, which is presumed to be of pathological significance. Several kinases catalyze Ser129 phosphorylation, but the role of phosphorylation enzymes in disease pathogenesis and their relationship to cellular toxicity from phosphorylation are not fully understood in α-synucleinopathy. Consequently, this review focuses on the pathogenic impact of α-synuclein phosphorylation and its kinases during the neurodegeneration process in α-synucleinopathy.     

基础沉降变形的灰色预测方法与电子表制作(Ⅱ)——电子表制作方法与技巧

通过工程实例详细说明基础沉降变形灰色预测模型电子表格的制作方法、应该注意的问题、电子表的保护及个性化设计方法。最后总结了如何以“制作好的预测模型电子表”为工具,非常方便地解决其他工程的预测问题,并用实例说明了具体的操作过程。为帮助广大工程技术人员解决程序设计的困难,提供灰色预测的有力工具,同时也为大家用活电子表格系统解决其他实际问题提供了参考。     

宿南矿区徐桥塌陷治理工程优选方案

因受祁南煤矿采煤影响而使徐桥塌陷成危桥,为保此桥安全正常使用,必须对桥进行加固处理或重建一座新桥。方案一是进行加固处理,方案二是重建一座新桥。经过对二方案进行优化比较,确定采用重建一座新桥的方案。     

采用起重机吊装桥梁工程的施工方法

采用起重机吊装预制梁,具有施工机具简单、易于操作、成本低、工期短、质量安全易于保证等优点。对于施工操作场地开阔、道路交通方便的中小桥梁工程,采用起重机吊装是一种较好的施工方法。     

并网型风力发电系统的研究

并网发电是大功率风力发电机组高效、大规模利用风能最经济的方式,已成为当今世界风能利用的主要形式。为促进我国的风电事业,概述了并网型风力发电系统的基本工作原理、工作方式和风力发电机的空气动力学特性以及并网型风力发电系统中5种典型的电路拓扑结构及其工作原理、并网技术和控制方法,还比较了不同拓扑结构下风力发电系统的性能和效率,给出了各自的典型应用。最后指出了各种方法的优缺点以及今后的发展方向。结果表明,随着大容量电力电子器件的发展和现代控制技术的引入,并网型风电系统中直驱式永磁同步发电机拓扑结构将会得到更多的应用和发展。并网型大功率风电机组控制系统中,风机模拟系统设计、发电机控制技术、并网技术、桨矩角控制技术和系统监控等关键技术的解决将有助于我国风电产业的国产化和大容量风电系统自主知识产权的建立。     

钙质砂地基中桶形基础垂直动载响应实验研究

首先进行了垂直静极限承载力实验,为确定垂直动载荷幅值的选择提供参考。然后重点针对栽荷幅值和频率的影响进行了系列的室内小模型实验,并对结果进行了分析,获得了垂直动载下桶形基础在钙质砂地基中的响应特点。     

3次加密挂环井井口计量准确度研究

3次加密井在投产过程中,对地面集输工艺流程进行了大力简化。简化流程后,井口计量存在的一个主要问题是软件量油的准确度。为此结合现场应用情况,对挂环井的计量问题进行分析、探讨,提出了挂环井的计量解决方案。     

IR2304半桥驱动集成电路的功能原理及应用

IR2304是美国IR公司生产的新一代半桥驱动集成芯片，该芯片内部集成了互相独立的控制驱动输出电路，可直接驱动两个中功率半导体器件如MOSFET或IGBT，动态响应快，驱动能力强，工作频率高，且具有多种保护功能。文中介绍了IR2304的功能特点、工作原理和典型应用电路。     

Consecutive Aromatic Residues Are Required for Improved Efficacy of β-Sheet Breakers

Alzheimer’s disease is a fatal neurodegenerative malady which up to very recently did not have approved therapy modifying its course. After controversial approval of aducanumab (monoclonal antibody clearing β-amyloid plaques) by FDA for use in very early stages of disease, possibly new avenue opened for the treatment of patients. In line with this approach is search for compounds blocking aggregation into amyloid oligomers subsequently forming fibrils or compounds helping in getting rid of plaques formed by β-amyloid fibrils. Here we present in silico work on 627 sixtapeptide β-sheet breakers (BSBs) containing consecutive three aromatic residues. Three of these BSBs caused dissociation of one or two β-amyloid chains from U-shaped β-amyloid protofibril model 2BEG after docking and subsequent molecular dynamics simulations. Thorough analysis of our results let us postulate that the first steps of binding these successful BSBs involve π–π interactions with stacked chains of F19 and later also with F20 (F3 and F4 in 2BEG model of protofibril). The consecutive location of aromatic residues in BSBs makes them more attractive for chains of stacked F3 and F4 within the 2BEG model. Spotted by us, BSBs may be prospective lead compounds for an anti-Alzheimer’s therapy.