MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System

Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment.     

一次220 kV保护误动作检查及处理

保护装置应定期检查,保证良好的运行工况。在条件允许的情况下,故障录波器的设置有利于故障分析、查找故障原因。     

基于DSP的双频超声波流量计硬件电路设计

超声波流量测量技术是一种利用超声波信号在流体中传播时所载流体的流速信息来测量流体流量的新的测量技术,他具有非接触式测量、测量精度高、测量范围宽、安装维护方便等特点,特别适合用于临时管道流量、大口径管道流量以及危险性流体流量的测量。本文介绍了一种采用数字信号处理技术的双频超声波流量计的硬件电路设计方法。     

IR2304半桥驱动集成电路的功能原理及应用

IR2304是美国IR公司生产的新一代半桥驱动集成芯片，该芯片内部集成了互相独立的控制驱动输出电路，可直接驱动两个中功率半导体器件如MOSFET或IGBT，动态响应快，驱动能力强，工作频率高，且具有多种保护功能。文中介绍了IR2304的功能特点、工作原理和典型应用电路。     

Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate,Fenofibric Acid,and Pemafibrate

Among the agonists against three peroxisome proliferator-activated receptor (PPAR) subtypes, those against PPARα (fibrates) and PPARγ (glitazones) are currently used to treat dyslipidemia and type 2 diabetes, respectively, whereas PPARδ agonists are expected to be the next-generation metabolic disease drug. In addition, some dual/pan PPAR agonists are currently being investigated via clinical trials as one of the first curative drugs against nonalcoholic fatty liver disease (NAFLD). Because PPARα/δ/γ share considerable amino acid identity and three-dimensional structures, especially in ligand-binding domains (LBDs), clinically approved fibrates, such as bezafibrate, fenofibric acid, and pemafibrate, could also act on PPARδ/γ when used as anti-NAFLD drugs. Therefore, this study examined their PPARα/δ/γ selectivity using three independent assays—a dual luciferase-based GAL4 transactivation assay for COS-7 cells, time-resolved fluorescence resonance energy transfer-based coactivator recruitment assay, and circular dichroism spectroscopy-based thermostability assay. Although the efficacy and efficiency highly varied between agonists, assay types, and PPAR subtypes, the three fibrates, except fenofibric acid that did not affect PPARδ-mediated transactivation and coactivator recruitment, activated all PPAR subtypes in those assays. Furthermore, we aimed to obtain cocrystal structures of PPARδ/γ-LBD and the three fibrates via X-ray diffraction and versatile crystallization methods, which we recently used to obtain 34 structures of PPARα-LBD cocrystallized with 17 ligands, including the fibrates. We herein reveal five novel high-resolution structures of PPARδ/γ–bezafibrate, PPARγ–fenofibric acid, and PPARδ/γ–pemafibrate, thereby providing the molecular basis for their application beyond dyslipidemia treatment.     

模块化多电平变换器优化调度调制策略研究

由于MMC电源的模块电容电压存在波动,一般认为它较为适用于定频运行。首先,定义了MMC电源的2种工作模式,即高效放电的工作模式和高效充电的工作模式;然后在此基础上提出了MMC电源的优化调度调制方法,该方法能够实现MMC变频变压运行时的低电容电压波动和高效控制;最后仿真结果验证了所提方法的有效性。     

改进新息图法在地区电网AVC系统中的应用

新息图法对于坏数据、拓扑变化的辨识有着显著效果.文中针对地区电网的辐射特性,提出了新息图法的分层辨识,建立了厂站层和联络线层新息图模型.当连支出现坏数据时,采用伪量测对其进行修正,避免了传统方法更换连支后需重新生成树的不足;支路预估值的准确程度将影响新息值的准确性,对此利用自动电压控制(AVC)系统潮流验证模块k时刻的在线潮流计算值与测量值的差值△P,按系数a对k+1时刻支路预估值进行趋近补偿,补偿后的潮流推算曲线更接近真值,提高了拓扑变化辨识的准确性.将以上改进的新息图法应用于四川省多个地区电网AVC系统,运行效果良好,能准确辨识坏数据和拓扑变化.     

一种低压燃料电池用逆变器的设计

研制了一种适用于低电压大电流输入的具有高频链燃料电池逆变器,详细介绍了这种逆变器的电路拓扑结构、控制策略和实现方法。该逆变器由前级Boost型推挽变换器和后级DC/AC逆变桥构成,为有效地提高逆变器的效率,在实际中采取了多种措施。研制了一台12V/50Hz/1kW的样机,通过工业现场中实际运行,表明该逆变器电气性能优良,为该逆变器在低压大电流工况下的应用提供了一种理想解决方案。     

高速动车组网侧电流谐波特性的研究

研究了高速动车组注入牵引网电流的谐波特性。分析了两电平及三电平4象限变流器的主电路拓扑及控制策略。利用双边傅立叶级数法,给出了两种4象限变流器网侧电流的谐波公式,总结了谐波分布规律。编制了CRH2和CRH5型动车组4象限变流器的仿真软件,研究了不同牵引和制动功率下,网侧电流的THD及各次谐波电流大小,验证了理论分析的正确性。