CMP230X-12AW型挤压造粒机组控制系统的改造

对日本制钢的CMP230X-12AW型挤压造粒机组的控制系统进行了全面升级改造.文中给出了改造方案,并对控制系统的功能、显示界面、操作系统进行说明.改造后,提高了生产效率和系统稳定性.     

Pharmaceutical production of tableting granules in an ultra-small-scale high-shear granulator as a pre-formulation study

Objective: In some of drug developments, the amount of bulk drug powder to use in early stages is limited and it is not easy to supply a sufficient drug amount for conventional preparation methods. Therefore, an ultra-small-scale high-shear granulator (less than 5?g) (USG) was developed and applied to small-scale granulation as a pre-formulation.

Method: The sample powder consisted of 66.5% lactose, 28.5% microcrystalline cellulose and 5.0% hydroxypropylcellulose. The granules were obtained to agitate 5?g of the sample powder with 1.0?mL of water at 300?rpm for 5?min after pre-powder mixing for 3?min by the USG and the manual hand (HM) methods.

Results: The granules were evaluated by the 10% and 90% accumulated particle size and the recoveries of the granules and the powder solid. Median particle size for the USG and the HM methods was 159.2?±?2.3 and 270.9?±?14.9 µm, respectively. The USG method had a narrower particle size distribution than those by the HM method. The recovery of the granules by USG was significantly larger than that by the HM method.

Conclusion: Characteristics of all of the granules indicated that the USG method could produce higher quality granules within a shorter time than the HM methods.     

粉状饲料混合制粒机的设计

针对粉状混合饲料的生产和运输、储藏中存在的问题,设计了融搅拌混合和颗粒成型为一体的饲料生产机械.介绍了整机的结构和工作原理,对饲料的混合室、搅拌器、螺旋输送挤压器、颗粒成型机构的主要结构特点及相应参数进行了分析与计算.     

延长切粒机使用周期的措施

分析了聚酯装置切粒机系统存在的问题 ,从工艺、操作、维修等方面提出了改进措施 ,延长了切粒机的使用周期     

造粒机氨化粒化差的原因分析及技改措施

青海云天化国际化工股份有限公司240kt／a磷酸二铵装置采用预中和加管式反应器转鼓氨化造粒工艺．造粒机运行状况一直不理想。通过对造粒机内部结构进行改造,降低了胶板使用量,二次氨利用率提高到70％以上,造粒机的运行率和产品质量也得到较大提高。     

稳定造粒机通氨量的意义和方法

以云峰公司３６ｔ／ｈ负荷生产ＤＡＰ（１８－４６－０）为例,介绍装置各点进出氨量。详细分析造粒机通氨量与料浆量不相匹配的各种影响因素及其不良后果,提出稳定造粒机通氨量使之与料浆量相匹配的方法。     

有机型复合颗粒肥生产线设计

有机型复合颗粒肥生产线用于加工以有机肥作基本介质,混配一定比例无机成分,适合各种经济作物养分和施肥要求的颗粒状全价营养肥料。     

10万吨／年重钙造粒机设计

介绍１０万吨／年重钙造粒机的主要设计参数及工艺设计计算,主要包括转鼓截面积、转速、倾斜度、功率和物料停留时间。     

An investigation on process of seeded granulation in a continuous drum granulator using DEM

Numerical simulation of wet granulation in a continuous granulator is carried out using Discrete Element Method (DEM) to discover the possibility of formation of seeded granules in a continuous process with the aim of reducing number of experimental trials and means of process control. Simple and scooped drum granulators are utilized to attain homogenous seeded granules in which the effects of drum rotational speed, particles surface energy, and particles size ratio are investigated. To reduce the simulation time a scale-up scheme is designed in which a dimensionless number (Cohesion number) is defined based on the work of cohesion and gravitational potential energy of the particles. Also a mathematical/numerical method along with a MATLAB code is developed by which the percentage of surface coverage of each granule is predicted precisely. The results show that use of continuous granulator for seeded granulation is promising provided that a high level of shear is considered in the granulator design, i.e. using baffles inside drum granulators is essential for producing seeded granules. It is observed that the optimum surface energy for seeded granulation in scooped granulator (used in this study) with rotational speed of 50 rpm is 3 J/m², which is close to the value predicted by the concept of Cohesion number. It is also shown that increasing the seed/fine size ratio enhances the seeded granulation both quantitatively (60% increase in seeds surface coverage) and qualitatively (more homogeneous granules).     

Effect of scale of operation on granule strength in high shear granulators

Results of a study on the influence of operation scale and impeller speed of high shear mixer granulators on the strength of granlues are reported in this paper. Calcium carbonate particles have been granulated in four scales of a geometrically similar high shear granulator (Cyclomix) with 1, 5, 50 and 250 L capacities. For the smallest scale, the effect of a small deviation from geometric similarity was also investigated. An aqueous solution of polyethylene glycol was used as the binder. Three scaling rules of constant tip speed, constant shear stress and constant Froude number have been used to determine the impeller speed for the different scales of the granulators. The granules produced in these experiments have been dried and tested for strength using side crushing test method. The data have then been analysed and compared. Operation of granulators according to the constant tip speed rule produces granules with a similar strength for all four scales, followed by a similar trend for the constant shear stress rule, albeit to the less extent. The constant Froude number rule produces a heterogeneous strength distribution and is not a suitable criterion for scaling-up of high shear granulators. The distribution of granule strength has been fitted to the normal, log-normal and Weibull distributions. Weibull distribution fits the data well for the constant tip speed operations.