高熔融指数聚丙烯对挤压造粒机运行的影响

研究了高熔融指数聚丙烯产品对挤压造粒机运行的影响,根据110 kt/a聚丙烯装置生产情况,将挤压造粒机操作参数作了相应的调整。     

对辊造粒机及其应用于磷石膏造粒的技术

磷石膏制水泥添加剂是磷石膏综合利用的一条有效途径。铜化集团通过试验对比在国内率先使用对辊造粒机进行磷石膏造球制水泥添加剂。介绍其在试生产中对对辊造粒机转速及型轮材质、球窝尺寸等的修复与改进情况,对国内同行有一定的借鉴作用。     

Granulation of ibuprofen/isonicotinamide co-crystals by continuous spray granulator (CTS-SGR)

The importance of granulation is paramount for tablet manufacturing, and is based on the fact that granulated powders are characterized by improved flowability, compressibility, segregation, and dust reduction. The aim of this study was to prepare and characterize continuous granules of high drug content by using a continuous-spray granulator (CTS-SGR). Ibuprofen (IBU), a drug of low-flowability, was selected as the model drug. As IBU has a low melting point and cannot easily granulate on its own, we employed isonicotinamide (INA) as a coformer that would allow us to prepare co-crystal granules containing 60 % IBU. The results of the undertaken differential scanning calorimetry and powder X-ray diffraction revealed that the IBU and the INA in the granules formed co-crystals. The granulation conditions affected the particle size and the yield of the granules; in fact, a low air supply temperature, a low atomizing air rate, and a high solution flow rate ensured a high granulation efficiency. Moreover, continuous granulation increased the yields of the formulations compared to those obtained through a short-run granulation, and high yields were obtained after applying a low atomizing air rate. The circularity of the granules exceeded 90 %, and their flowability improved when compared to that of the IBU bulk. The undertaking of dissolution studies revealed no change in the elution amount of IBU as a result of the co-crystallization. Our study shows that it is possible to produce high-content IBU granules in a direct and continuous manner through the co-crystallization of IBU and the use of a CTS-SGR.     

CFD-DEM Simulation of Superquadric Cylindrical Particles in a Spouted Bed and a Rotor Granulator

The fluidization behavior of cylindrical particles in a spouted bed was first investigated experimentally using a camera setup. The obtained average spouted bed height was used to evaluate the accuracy of different drag models in CFD-DEM simulations with the superquadric approach to model the particle shape. The drag model according to Sanjeevi et al. showed the best agreement. With this model, cylindrical particles were simulated in a rotor granulator and the particle dynamics were compared with the fluidization of volume equivalent spherical particles.