Augment low-field intra-operative MRI with preoperative MRI using a hybrid non-rigid registration method

Background

Preoperatively acquired diffusion tensor image (DTI) and blood oxygen level dependent (BOLD) have been proved to be effective in providing more anatomical and functional information; however, the brain deformation induced by brain shift and tumor resection severely impairs the correspondence between the image space and the patient space in image-guided neurosurgery.

Method

To address the brain deformation, we developed a hybrid non-rigid registration method to register high-field preoperative MRI with low-field intra-operative MRI in order to recover the deformation induced by brain shift and tumor resection. The registered DTI and BOLD are fused with low-field intra-operative MRI for image-guided neurosurgery.

Results

The proposed hybrid registration method was evaluated by comparing the landmarks predicted by the hybrid registration method with the landmarks identified in the low-field intra-operative MRI for 10 patients. The prediction error of the hybrid method is 1.92 ± 0.54 mm, and the compensation accuracy is 74.3 ± 5.0%. Compared to the landmarks far from the resection region, those near the resection region demonstrated a higher compensation accuracy (P-value = .003) although these landmarks had larger initial displacements.

Conclusions

The proposed hybrid registration method is able to bring preoperatively acquired BOLD and DTI into the operating room and compensate for the deformation to augment low-field intra-operative MRI with rich anatomical and functional information.     

基于复合左右手传输线结构的新型微带天线

基于复合左右手传输线结构的零阶谐振理论,提出了一种新型双层结构的微带天线,仿真结果表明该天线具有比单层微带天线更小的尺寸。研究了天线各结构参数对天线特性的影响,并对各参数进行了优化仿真。仿真结果表明该天线具有全向辐射特性,与传统微带天线相比,该天线具有体积小的特点。     

基于表面等离子体共振传感器的尿微量白蛋白检测

检测尿微量白蛋白(MAU)可对轻微肾脏损害进行早期诊断,也可对高血压患者可能发生的心脑血管事件进行预测。实验将抗体通过巯基自组装固定于Au膜表面,研制了一种快速检测MAU的表面等离子体共振(SPR)生物传感器。结果表明:直接检测法可以检测到0.3μg/L的MAU,而纳米Au放大法检测限可以低至0.03μg/L。     

Structure and properties of polyimide‐bonded magnets processed from prepolymers based on diacetyl derivatives of aromatic diamines and dianhydrides

We report a novel method of polyimide (PI) synthesis from prepolymers based on dianhydrides and diacetyl derivatives of aromatic diamines that facilitate the preparation of a melt processable mixture at 300 ± 10°C of the prepolymer and magnetic Nd‐Fe‐B alloy to provide PI‐bonded magnets with enhanced properties. It is shown that chemical structure of the prepolymers strongly influences viscosity behavior via crystallization of the oligoimide in the melt, leading to formation of PI with rigid‐rod like structure. This structural ordering of the prepolymers based on diacetyl derivative of diamine used in this study, if not controlled, leads to exponential increase of melt viscosity with time, making it practically impossible to prepare melt processable mixture of the magnetic particles and the PI prepolymers at elevated temperatures. The results obtained demonstrate that appropriate dianhydrides and diacetyl derivatives of diamines that do not lead to crystallization of oligoimides in prepolymer mixture can be used under controlled processing conditions to prepare melt‐processable PI‐bonded magnets containing rigid‐rod like PI structure that significantly increases thermal stability of the magnets. The temperature dependencies of the magnetic properties of the PI‐bonded magnets under conditions that they are likely to encounter during their service life were found to be remarkably similar to that of commercial thermoplastic magnets such as injection‐molded nylon magnets. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 478–485, 2006     

受限波兹曼机联合稀疏近似的脑功能检测模型

人脑功能连通性检测是神经科学研究的重要技术．使用受限制波兹曼机（RestrictedBoltzmannMachine,RBM）对大量多被试功能磁共振（functionalMagneticResonanceImaging,fMRI）数据进行建模可以检测人脑功能连接,但是不能有效检测单被试数据的功能连接．本文研究一种新颖的融合了稀疏近似与RBM技术的脑功能连通性检测模型,该模型充分利用fMRI数据的稀疏性,采用稀疏近似理论对fMRI数据进行空间域稀疏近似压缩,然后使用RBM建立模型,以检测脑功能连通性．实验结果表明,该融合模型可以有效地提取单被试数据的脑功能时间域混合模型及其相应的脑功能图谱,解决了RBM在单被试数据分析上的瓶颈．     

Effects of oxidation on I2 doping of trans-polyacetylene as studied via e.s.r. and conductivity measurements

Oxidation of trans-polyacetylene lowers the activation energy for conduction from 16 kcal mol^?1 to 11 kcal mol^?1 for oxidation levels of (C₂H₂O_n)_x, n = 0.144, 0.207 and 0.550. Maximum conductivity levels for 0 < x < 0.144 doped with I₂ were almost identical. At long I₂ doping times all samples exhibited some loss of conductivity. E.s.r. experiments indicate that: (1) linewidth is directly proportional to oxygen content, and (2) iodine doping is not diffusion controlled. All data are consistent with a molecular picture of PAC consisting of highly reactive localized spin states that are selectively oxidized, and less reactive delocalized states that affect conductivity more strongly via doping.     

MA制备GdSiGeDy合金系室温磁制冷性能研究

机械合金化(MA)是一种材料固态非平衡加工新技术.本文主要探讨稀土元素Dy在机械合金化工艺条件下对磁制冷合金GdSiGe磁熵变的影响,发现用机械合金化制备的GdSiGeDy合金系室温磁制冷材料不仅有光滑的磁熵变曲线,而且研究表明,由于元素Dy的加入在磁熵变达到单质Gd的两倍情况下大量减少使用昂贵元素Ge的结果,具有明显经济效益.     

Factors influencing magnetic polymer microspheres prepared by dispersion polymerization

Magnetic iron oxide (Fe₃O₄) was prepared by a coprecipitation method. Core–shell composite magnetic polymer microspheres with carboxyl groups were synthesized by the dispersion polymerization of styrene and acrylic acid in the presence of magnetic oxide, and dibenzoyl peroxide was used as an initiator. The synthesized magnetic polymer microspheres were characterized with X‐ray diffraction, transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, and so forth. The results indicated that the product was single‐phase Fe₃O₄, and its average size was about 10 nm. The configuration of the microspheres, which contained carboxyl groups, was spherical, and the average size was about 2 μm. The results of vibrating sample magnetometry tests showed that the magnetic powders produced by different surfactants had different saturation magnetizations. When poly(ethylene glycol) with a weight‐average molecular weight of 4000 was used as a surfactant, the saturation magnetization of the samples reached 69.2 emu/g. The factors that affected the shape, magnetism, size, and distribution of the microspheres were also studied. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007     

光化学反应中的磁场效应 Ⅱ.电子转移光敏化1,2-二苯乙烯的顺反异构化反应

前文报道了外加磁场对吸附在硅胶表面上的芳砜光解反应的影响,本文报道外加磁场影响光化学反应的另一个例子——电子转移光敏化1,2-二苯乙烯的异构化。 近年来电子转移光敏化反应引起了有机光化学家们的极大注意。一些异构化、重排、裂解、氧化反应都可以通过电子转移机理敏化。电子转移光敏化的机理可以用(1)描述。图中A和D分别代表电子的受体和给体。