Unexpected products of the allyldiethylamine hydroformylation homogeneously catalyzed by rhodium complexes

Attempts to carry out the hydroformylation of allyldiethylamine homogeneously catalyzed by rhodium complexes led to unexpected formation of N,N,N,N-tetraethyl-1,4-diaminobutane and 4-(diethylamino)-1-butanole as final products. The role of the catalyst on the product formation and the reaction mechanism are briefly discussed.     

Effects of α-Terthienyl on the midgut detoxification enzymes of the European corn borer,Ostrinia nubilalis

The biochemical basis for the tolerance of the European corn borer,Ostrinia nubilalis, to the phototoxin-terthienyl was investigated by measuring the midgut polysubstrate monooxygenases and glutathioneS-transferase activities.-Terthienyl administered in the diet to the corn borers increased the level of cytochromeb ₅, NADH-cytochromec reductase,O-demethylase, and glutathioneS-transferase activities. The induced detoxification enzyme activities should enable the corn borer to metabolize-terthienyl more efficiently and therefore render the corn borer highly tolerant to-terthienyl.     

元数学对计算机科学的启示

文章提出了元数学对计算机科学的几点启示,这几个方面分别是传统程序设计的概念、机制、要素,数据库技术中的数据模型和函数依赖,面向对象分析和设计方法。文中一方面分析了元数学所提供的理论基础,另一方面说明了在应用方面是如何体现这些理论基础的,并提出了在计算机技术领域中应从数学基础问题、数理逻辑等的相关理论着手寻找突破的思想。     

基于Jacobian-Free Newton-GMRES(m)方法的电力系统分布式暂态仿真算法

分布式暂态仿真是实现市场环境下互联电力系统在线一体化仿真分析的有效途径.文中研究了电力系统分布式暂态仿真计算模型,提出了基于Jacobian-Free Newton-GMRES(m)方法的协调求解算法.该算法只需要交换边界母线状态信息,接口简单,实用性强.为了提高算法收敛速度,减少协调求解所需通信次数,提出了自适应预处理和连续修正预处理矩阵、预估边界条件初值及多时步同时协调等改进方法并将其应用于新算法中.测试结果表明,新的暂态仿真分解协调算法收敛快,通信次数少,非常适合在基于广域网络的分布式环境中实现.     

The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis

Gastric cancer (GC) is the fifth most common cancer and the third deadliest cancer in the world, and the occurrence and development of GC are influenced by epigenetics. Methyltransferase-like 3 (METTL3) is a prominent RNA n6-adenosine methyltransferase (m6A) that plays an important role in tumor growth by controlling the work of RNA. This study aimed to reveal the biological function and molecular mechanism of METTL3 in GC. The expression level of METTL3 in GC tissues and cells was detected by qPCR, Western blot and immunohistochemistry, and the expression level and prognosis of METTL3 were predicted in public databases. CCK-8, colony formation, transwell and wound healing assays were used to study the effect of METTL3 on GC cell proliferation and migration. In addition, the enrichment effect of METTL3 on DEK mRNA was detected by the RIP experiment, the m6A modification effect of METTL3 on DEK was verified by the MeRIP experiment and the mRNA half-life of DEK when METTL3 was overexpressed was detected. The dot blot assay detects m6A modification at the mRNA level. The effect of METTL3 on cell migration ability in vivo was examined by tail vein injection of luciferase-labeled cells. The experimental results showed that METTL3 was highly expressed in GC tissues and cells, and the high expression of METTL3 was associated with a poor prognosis. In addition, the m6A modification level of mRNA was higher in GC tissues and GC cell lines. Overexpression of METTL3 in MGC80-3 cells and AGS promoted cell proliferation and migration, while the knockdown of METTL3 inhibited cell proliferation and migration. The results of in vitro rescue experiments showed that the knockdown of DEK reversed the promoting effects of METTL3 on cell proliferation and migration. In vivo experiments showed that the knockdown of DEK reversed the increase in lung metastases caused by the overexpression of METTL3 in mice. Mechanistically, the results of the RIP experiment showed that METTL3 could enrich DEK mRNA, and the results of the MePIP and RNA half-life experiments indicated that METTL3 binds to the 3’UTR of DEK, participates in the m6A modification of DEK and promotes the stability of DEK mRNA. Ultimately, we concluded that METTL3 promotes GC cell proliferation and migration by stabilizing DEK mRNA expression. Therefore, METTL3 is a potential biomarker for GC prognosis and a therapeutic target.     

三峡船闸四级运行方式优化研究

针对三峡船闸在四级运行方式下,二闸室充水过程中一闸室待闸条件不佳和充水时间超过设计允许值的问题,采用在二闸室充水前关闭一闸首人字门+快速开启阀门的运行方式,并在原型上进行了调试优化.水力学观测、实船试验及分析表明,这一运行方式从根本上改善了一闸室的待闸条件,显著提高了船舶待闸的安全性,并使一、二闸室充水时间缩短到与后续闸室一致,满足了不大于12 min的设计要求,彻底改变了四级运行方式下二闸室充水过程成为延长船舶过闸时间关键的现状,可使日通过闸次由一闸室不待闸的13～14.5次提高到18.7～22.1次.     

CHINALCO Seek Rare Earth Project in Guangdong

【正】CHINALCO and the Qingyuan municipal government in Guangdong will sign a framework agreement at the beginning of 2011 to jointly tap local rare earth resource...     

LD端面泵浦的1.57μm内腔式OPO

1.57 μm波长激光为人眼安全波长激光。将KTP晶体置于一个由LD端面泵浦、声光调Q的Nd:YVO4晶体双凹谐振腔内,利用KTP表面镀膜建立了内腔式OPO,实现了重复率在5～40 kHz范围内1.57 μm脉冲激光的稳定输出。实验结果表明,激光的阈值将随声光调Q器重复率的增加而升高,重复率为5 kHz时得到最低阈值1.52 W。重复率为15 kHz、泵浦功率为3.7 W时,输出光平均功率为305 mW,脉冲宽度50 ns,峰值功率400 W。     

基于VHDL可编程m序列发生器的研制

提出一种可实现周期／初相位编程控制的m序列发生器逻辑电路的设计方案。给出了VHDL与CPLD的实现方案。程序经编译、仿真、测试后，可以实现设计要求。该器件在MCS51的控制下，实现m序列的周期、初相位的编程变化．