一种新的无线电高度表原位检测的高度模拟方法

针对目前对高度表进行原位检测的需求,设计了一种新的高度模拟方法;该方法的实现以ARM为核心,通过高度模拟电路产生各种需要的高度电压信号,从而达到高度模拟的目的,并且无需对机载高度表进行拆装,操作简单、快捷、可靠性较高;实验结果表明,这种方法的高度模拟精度较高,具有一定的实用价值和经济效益.     

Adenovirus-Mediated Inducible Expression of a PD-L1 Blocking Antibody in Combination with Macrophage Depletion Improves Survival in a Mouse Model of Peritoneal Carcinomatosis

Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a growing number of malignancies. However, overcoming primary or secondary resistances is difficult due to pharmacokinetics issues and side effects associated with high systemic exposure. Local or regional expression of monoclonal antibodies (mAbs) using gene therapy vectors can alleviate this problem. In this work, we describe a high-capacity adenoviral vector (HCA-EFZP-aPDL1) equipped with a mifepristone-inducible system for the controlled expression of an anti-programmed death ligand 1 (PD-L1) blocking antibody. The vector was tested in an immune-competent mouse model of colorectal cancer based on implantation of MC38 cells. A single local administration of HCA-EFZP-aPDL1 in subcutaneous lesions led to a significant reduction in tumor growth with minimal release of the antibody in the circulation. When the vector was tested in a more stringent setting (rapidly progressing peritoneal carcinomatosis), the antitumor effect was marginal even in combination with other immune-stimulatory agents such as polyinosinic-polycytidylic acid (pI:C), blocking mAbs for T cell immunoglobulin, mucin-domain containing-3 (TIM-3) or agonistic mAbs for 4-1BB (CD137). In contrast, macrophage depletion by clodronate liposomes enhanced the efficacy of HCA-EFZP-aPDL1. These results highlight the importance of addressing macrophage-associated immunoregulatory mechanisms to overcome resistance to ICIs in the context of colorectal cancer.     

MS900轧机液压锁的故障及分析

针对MS900轧机生产中遇到的问题,重点对因双锁取代单锁、液压锁安装位置错误及配套使用的换向阀型号不符等引发的故障及产生原因进行了分析。     

基于Visual Basic 开发机床主传动非常规变速系统的设计--重复转速的传动系统(实例之二)

本文介绍利用Visual Basic工具开发金属切削机床主传动非常规变速系统的设计总体结构，功能和方法，以重复转速的传动系统为例，重点介绍转速图的拟定过程，本系统具有界面美观，操作方便，易于理解的特点。     

汽车覆盖件成形过程数值模拟研究

本文介绍汽车覆盖件成形过程有限元模拟两个软件ＩＴＡＳ—３Ｄ和ＤＹＮＡＭＩＣ的最新研究成果，基本原理和有关接触搜索、摩擦和拉伸筋模型等关键技术。并有两个应用实例     

多关节机器人通用体系结构的研究

结合一个五自由度教学工业两用型机器人应用实例，构造出多关节机器人通用体系结构，包括总体原型、机械结构、关节传动链、伺服驱动元件、电气控制系统、关节坐标系及其运动学方程、通信协议和软件设计思路等。通过实际使用表明，本文提出的通用体系结构是实用的、合理的。     

回火过程应力场计算机模拟

回火过程应力场计算机模拟林家骝，杨振枢，于震宗，段贵明（清华大学）郭剑仁，史全兴，谢克仁（内蒙古第一机器厂）ＡＳｔｕｄｙｏｆＮｕｍｅｒｉｃａｌＳｉｍｕｌａｔｉｏｎｏｆＳｔｒｅｓｓＦｉｅｌｄｄｕｒｉｎｇＴｅｍｐｅｒｉｎｇ￥ＬｉｎＪｉａｌｉｕ；ＹａｎｇＺ...     

Kynar—500涂装工艺与涂层性能研究

介绍了Kynar－500涂料的涂装工艺，并对涂层的性能作了试验与分析。     

Analysis of the oscillatory behavior of double-walled carbon nanotube-based oscillators

Molecular dynamics simulations of oscillatory behaviors of double-walled carbon nanotube-based oscillators are performed. The second-generation empirical bond-order potential is used for the atomic interactions within a wall, and a registry-dependent and four different registry-independent van der Waals potentials are used for the atomic interactions between walls. It is found that the frequencies of the nanotube oscillators are sensitive to the choice of the van der Waals potentials. An almost non-decay oscillation is observed for the registry-dependent potential when there is no rocking motion. However, an apparent decay oscillation is observed when rocking motion occurs. A decay oscillation is observed for all registry-independent potentials even without rocking motion. Mechanisms leading to unstable oscillatory behavior are analyzed.