Sex-Related Differences in Regional Blood–Brain Barrier Integrity in Non-Demented Elderly Subjects

The role of the blood–brain barrier (BBB) breakdown has been recognized as being important in Alzheimer’s disease pathogenesis. We aimed to evaluate whether regional BBB integrity differed according to sex and whether differences in BBB integrity changed as a consequence of aging or cognitive decline, using dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI). In total, 75 participants with normal cognition (NC) or mild cognitive impairment (MCI) underwent cognitive assessments and MRI examination including DCE-MRI. Regional K_trans was calculated in cortical regions and the Patlak permeability model was used to calculate BBB permeability (K_trans, min⁻¹). Females had a lower median K_trans in the cingulate and occipital cortices. In the “older old” group, sex differences in K_trans were only observed in the occipital cortex. In the MCI group, sex differences in K_trans were only observed in the occipital cortex. Age was the only predictor of cognitive assessment scores in the male MCI group; however, educational years and K_trans in the occipital cortex could predict cognitive scores in the female MCI group. Our study revealed that females may have better BBB integrity in cingulate and occipital cortices. We also found that sex-related differences in BBB integrity are attenuated with aging or cognitive decline.     

多干扰源下热连轧机主传动系统扭振问题研究

针对热连轧机主传动系统扭转振动问题,考虑非线性刚度及阻尼项,建立连轧机在电机谐波干扰及负载谐波干扰下的主传动系统扭转动力学模型。采用多尺度法求解非线性动力学系统的1/2倍亚谐、2倍超谐及组合共振幅频响应方程。以某钢企中1 580 mm热连轧机F2主传动系统为例,分析实际参数下不同非线性刚度、非线性阻尼、电机扰动及线性阻尼对主传动系统亚谐、超谐及组合共振的幅频响应的影响。研究结果为揭示热连轧机主传动系统非线性动力学特性问题机理提供实用参考。     

参激随机共振及纠错码技术的应用

为了有效地降低数字信号传输过程中的比特误码率,提出了纠错编码与参数调节随机共振技术的结合.在经过噪声污染后,依据参数调节随机共振技术的性质,给出通过系统参数调节的二进制脉冲幅值调制（PAM）输入信号的渐近误码率公式,应用纠错码技术采用中间值估计的方法得到修正的比特误码率.数字仿真试验证实,理论计算结果与试验结果相吻合,纠错码技术与参激随机共振技术的结合应用于二进制基带信号传输,可以降低误码率,从而可以得到更好的效果,提高通信的可靠性和有效性.     

直流闭锁故障下风电并网功率和直流输送功率的耦合关系分析

中国一次能源和负荷成逆向分布,新能源基地集群通过特高压直流群外送,新能源高占比电网中风电和直流耦合关系复杂。首先,建立电网分析模型,研究风电和直流在电网频率、电压方面的耦合关系。其次,根据最大频率偏差耐受能力,计算风电和直流在频率方面的耦合关系。再次,根据直流闭锁故障后风电暂态过电压总脱网量约束,推导风电并网点的暂态压升,计算暂态压升和脱网量的关系,得到直流和风电在暂态过电压方面的耦合关系。理论计算结果表明：风电和直流呈负相关性。根据2020年西北电网青豫直流和近区风电并网功率的仿真结果,验证了理论推导的正确性。     

高压输电线路在线监测设备无线供电磁耦合机构优化

对高压输电线路进行实时精准的在线监测是保障电网稳定运行的有效手段。磁耦合共振无线供电为解决在线监测设备供电困难的问题提供了一种可行方案,但传统磁耦合共振系统耦合程度弱,传输效率对传输距离变化敏感,总体性能欠佳。基于电路模型分析了耦合线圈互感对传输效率的影响,提出了考虑线圈与磁芯耦合影响关系的联合优化方案从而提升传输性能。仿真和实验结果验证了在同轴间距、水平和角度偏移变化时的系统效率提升。为提升磁耦合系统传输效率和距离提供了一种有效方案。     

电缆化配电系统高频谐振频移方法

为解决电缆化配电网高频谐振问题,提出了一种基于配电网阻抗重构的高频谐振频移方法。首先,分析了电缆化配电网高次谐波源与高频谐振的产生机理。其次,给出了电缆化配电网阻抗重构的高频谐振频移方法,并比较不同无源阻抗重构后的频移及谐振峰抑制效果。然后,结合实际工程案例,利用系统函数绘出伯德图与根轨迹评价该方法对高频谐振治理效果以及系统稳定性的影响,验证了基于电缆化配电网阻抗重构的高频谐振频移方法的有效性,最后研究了无源阻抗参数变化对配电网高频谐振的影响。     

Effects of Adenine Methylation on the Structure and Thermodynamic Stability of a DNA Minidumbbell

DNA methylation is a prevalent regulatory modification in prokaryotes and eukaryotes. N¹-methyladenine (m¹A) and N⁶-methyladenine (m⁶A) have been found to be capable of altering DNA structures via disturbing Watson–Crick base pairing. However, little has been known about their influences on non-B DNA structures, which are associated with genetic instabilities. In this work, we investigated the effects of m¹A and m⁶A on both the structure and thermodynamic stability of a newly reported DNA minidumbbell formed by two TTTA tetranucleotide repeats. As revealed by the results of nuclear magnetic resonance spectroscopic studies, both m¹A and m⁶A favored the formation of a T·m¹A and T·m⁶A Hoogsteen base pair, respectively. More intriguingly, the m¹A and m⁶A modifications brought about stabilization and destabilization effects on the DNA minidumbbell, respectively. This work provides new biophysical insights into the effects of adenine methylation on the structure and thermodynamic stability of DNA.     

Role of Chiral Configuration in the Photoinduced Interaction of D- and L-Tryptophan with Optical Isomers of Ketoprofen in Linked Systems

The study of the L- and D-amino acid properties in proteins and peptides has attracted considerable attention in recent years, as the replacement of even one L-amino acid by its D-analogue due to aging of the body is resulted in a number of pathological conditions, including Alzheimer’s and Parkinson’s diseases. A recent trend is using short model systems to study the peculiarities of proteins with D-amino acids. In this report, the comparison of the excited states quenching of L- and D-tryptophan (Trp) in a model donor–acceptor dyad with (R)- and (S)-ketoprofen (KP-Trp) was carried out by photochemically induced dynamic nuclear polarization (CIDNP) and fluorescence spectroscopy. Quenching of the Trp excited states, which occurs via two mechanisms: prevailing resonance energy transfer (RET) and electron transfer (ET), indeed demonstrates some peculiarities for all three studied configurations of the dyad: (R,S)-, (S,R)-, and (S,S)-. Thus, the ET efficiency is identical for (S,R)- and (R,S)-enantiomers, while RET differs by 1.6 times. For (S,S)-, the CIDNP coefficient is almost an order of magnitude greater than for (R,S)- and (S,R)-. To understand the source of this difference, hyperpolarization of (S,S)-and (R,S)- has been calculated using theory involving the electron dipole–dipole interaction in the secular equation.     

基于SWT的GIS电压互感器二次侧干扰分析

特快速暂态过电压（VFTO）是气体绝缘变电站（GIS）中切换隔离开关时产生的特殊电磁暂态现象。VFTO会以传导和辐射方式影响二次设备的正常运行。为探究VFTO对二次设备的干扰特性,文中采用自制的二次侧干扰测量装置对某1 000 kV GIS的电压互感器（PT）二次侧共模干扰进行现场实测。接着,对比了5种时频分析方法的性能,采用其中性能较优的同步压缩小波变换（SWT）对实测波形进行了时频分析。实测结果表明：PT二次侧的共模干扰电压峰峰值最高可达9.65 kV。微脉冲的时频分析结果表明：7.8 MHz频率分量幅值高,且贯穿波形的始终,是PT二次侧干扰的主导频率分量。该分析结果可为GIS中二次设备的电磁抗扰度测试和电磁防护设计提供参考。     

新型防雷及抗干扰方法在电铲控制系统的应用

电铲是采区主要采掘设备,其弱电控制系统是电铲正常可靠运行的关键。由于雷击或电磁干扰造成弱电控制系统装置的损坏或工作异常等故障,已成为影响电铲安全正常运行的重要因素。针对现有电铲控制系统防雷抗干扰现状、存在的问题及影响,研究了一种新型防雷抗干扰方法,并分析了其在电铲弱电控制系统中的应用和实施效果。实际运行表明,新型防雷抗干扰方法能够有效提高电铲弱电控制系统防雷及抗干扰能力,对电铲及其他弱电控制系统防雷抗干扰的研究和应用具有积极的现实意义,且有着很好的推广价值。