Surface plasmon resonance evaluation of various aminoglycoside-RNA hairpin interactions reveals low degree of selectivity

Aminoglycoside antibiotics, which are able to selectively bind to RNA, are considered to be an important lead in RNA-targeting drug discovery. In this study, surface plasmon resonance (SPR) was employed to explore the interaction of aminoglycosides with known tobramycin-binding RNA hairpins (aptamers) and an unrelated RNA hairpin. It was established that aminoglycosides have multiple interactions with RNA hairpins. Unexpectedly, the different hairpins showed comparable affinity for a set of related aminoglycosides. The observed absence of selectivity presents an extra hurdle in the discovery of novel aminoglycosides as specific drugs that target defined RNA hairpins.     

Chaos in parametric resonance flow at water-mercury interface

In the electrochemical system with liquid-liquid interface, intense local convections by the resonance with potential pulses take place. Therefore, with laser beam scattering, temporal movement of the water-mercury interface was observed. As a result, the scattering efficiency showed non-linear oscillation.

Such non-linear response could be controlled by potential pulse height. As the potential height was increased, new scattering peaks in the oscillation emerged, which was expected of a kind of bifurcation phenomenon. From these results, phase portrait, Poincarè section, correlation dimension of the strange attractor and the largest Lyapunov exponent of the trajectories were obtained. Consequently, it was concluded that all the parameters indicate chaotic behavior of the resonance flow.     

Enhancement in magnetic permeability of Ni-Co-Zn ferrites using CuO doping for RF and microwave devices

Novel soft magnetic ferrite materials will play a crucial role in next-generation trillion-dollar sensor technologies related to 5G communications and internet of things as these materials can achieve improved wireless power/signal transfer efficiency with high operation frequency. In this work, Ni_0.4Co_0.25Zn_0.35Fe₂O₄ ferrites with high permeability and low magnetic loss were prepared for RF and microwave device applications. Composition and microstructure control is crucial to obtain the desired magnetic and loss properties. CuO dopant (x = 0 wt% to 20 wt%) were employed during the synthesis of Ni_0.4Co_0.25Zn_0.35Fe₂O₄ ferrite specimens to modify the microstructures, thus improving the magnetic properties of the ferrites. High value of measured relative permeability (μ’ of 4-10) and relatively low magnetic loss tangent ( of 0.01-0.1) has been achieved at frequency range between 100 and 800 MHz. Addition of CuO, especially up to 3 wt%, can cause a significant increase in permeability. Real part of the permeability of 3.87 and 10.9 has been achieved for undoped and 3 wt% CuO doped specimens, while noticeable reduction in magnetic losses has been observed for the doped sample measured at 400 MHz. The resonance frequency of synthesized ferrites has also been shifted into GHz range, when higher concentration of CuO dopants (>5 wt%) were employed.     

EPR study of hydrogen-related defects in boron-doped p-type CVD homoepitaxial diamond films

Boron-doped p-type single crystalline chemical vapor deposition (CVD) homoepitaxial diamond films were investigated by electron paramagnetic resonance (EPR). Carbon dangling bond defects, which were accompanied by a nearby hydrogen atom, were observed in boron-doped p-type CVD diamond films on a IIa substrate similar to those observed in undoped diamond. This result suggested that the energy level position of the defects is located below the Fermi energy of boron-doped diamond, at around 0.3 eV above the valence-band top. The reason why the Fermi energy could be changed by the incorporation of boron atoms at low density (10¹⁶–10¹⁷/cm³) in the film in spite of the existence of the large defect density of EPR centers (10¹⁸/cm³) is thought to be that the singly occupied electron states of defects are located near the band edge. As for the thermal annealing effect of the defects, it was revealed that the concentration of the defects and the mobility of the p-type film did not change after annealing up to 1200 °C which is much higher than the temperature of boron–hydrogen pair dissociation.     

Variable temperature13C MAS NMR of KFe2Mn(CO)12 in the solid state and as aCatalyst precursor on a carbon support

Variable temperature¹³C MAS NMR spectra are reported for¹³CO-enriched KFe₂Mn(CO)₁₂ as a solid and also as dispersed clusters on a carbon support. The spectrum of KFe₂Mn(CO)₁₂ at 300 K agrees with the proposed structure for this cluster and shows that the cluster is static. Two bridging carbonyl resonances are clearly resolved and, by comparison with¹³C MAS NMR spectra of Mn₂(CO)₁₀ and Fe₂(CO)₉, all terminal resonances for the cluster can be assigned. When the cluster is supported on carbon, two broad resonances are observed at room temperature which are assignable to KFe₂Mn(CO)₁₂ and a decomposition product, Mn₂(CO)₁₀. The carbonyl ligands in both supported clusters are completely averaged, and KFe₂Mn(CO)₁₂ on the carbon surface demonstrates fluxional behavior similar to that observed for the cluster in solution. For this fluxional process, activation energies of 0.6 kcal/mol and 0.5 kcal/mol are estimated for carbon-supported KFe₂Mn(CO)₁₂ and Mn₂(CO)₁₀, respectively.     

受限波兹曼机联合稀疏近似的脑功能检测模型

人脑功能连通性检测是神经科学研究的重要技术．使用受限制波兹曼机（RestrictedBoltzmannMachine,RBM）对大量多被试功能磁共振（functionalMagneticResonanceImaging,fMRI）数据进行建模可以检测人脑功能连接,但是不能有效检测单被试数据的功能连接．本文研究一种新颖的融合了稀疏近似与RBM技术的脑功能连通性检测模型,该模型充分利用fMRI数据的稀疏性,采用稀疏近似理论对fMRI数据进行空间域稀疏近似压缩,然后使用RBM建立模型,以检测脑功能连通性．实验结果表明,该融合模型可以有效地提取单被试数据的脑功能时间域混合模型及其相应的脑功能图谱,解决了RBM在单被试数据分析上的瓶颈．     

变速直驱开关磁阻风力发电系统雷电防护技术研究

根据风力发电机组防雷保护的研究成果和相关行业防雷标准,分析雷电的形成、破坏机理及其破坏形式。结合开关磁阻风力发电系统特征,划分雷电防护区域;按照风力发电机组防雷设计应该遵循的原则,通过外部防护和内部防护相结合,提出开关磁阻风力发电系统各部件防雷保护措施。为工程实践中开关磁阻风力发电系统的雷电防护提供一定的参考。     

Effects of oxidation on I2 doping of trans-polyacetylene as studied via e.s.r. and conductivity measurements

Oxidation of trans-polyacetylene lowers the activation energy for conduction from 16 kcal mol^?1 to 11 kcal mol^?1 for oxidation levels of (C₂H₂O_n)_x, n = 0.144, 0.207 and 0.550. Maximum conductivity levels for 0 < x < 0.144 doped with I₂ were almost identical. At long I₂ doping times all samples exhibited some loss of conductivity. E.s.r. experiments indicate that: (1) linewidth is directly proportional to oxygen content, and (2) iodine doping is not diffusion controlled. All data are consistent with a molecular picture of PAC consisting of highly reactive localized spin states that are selectively oxidized, and less reactive delocalized states that affect conductivity more strongly via doping.     

惯性往复振动机械阻尼值设计的理论研究

建立了双旋转偏重激振的惯性往复振动机械的状态方程,将该状态方程与两驱动电机的状态方程一起组成机电耦合系统的数学模型,对不同阻尼的机电耦合数学模型进行数值求解,得到不同阻尼时系统的瞬态和稳态解.通过综合分析系统阻尼对最大共振振幅、启动时间、稳态功率消耗及阻尼力的影响,提出了惯性往复振动机械阻尼率的合理设计值为0.1左右.