A Web Server for Designing Molecular Switches Composed of Two Interacting RNAs

The programmability of RNA–RNA interactions through intermolecular base-pairing has been successfully exploited to design a variety of RNA devices that artificially regulate gene expression. An in silico design for interacting structured RNA sequences that satisfies multiple design criteria becomes a complex multi-objective problem. Although multi-objective optimization is a powerful technique that explores a vast solution space without empirical weights between design objectives, to date, no web service for multi-objective design of RNA switches that utilizes RNA–RNA interaction has been proposed. We developed a web server, which is based on a multi-objective design algorithm called MODENA, to design two interacting RNAs that form a complex in silico. By predicting the secondary structures with RactIP during the design process, we can design RNAs that form a joint secondary structure with an external pseudoknot. The energy barrier upon the complex formation is modeled by an interaction seed that is optimized in the design algorithm. We benchmarked the RNA switch design approaches (MODENA+RactIP and MODENA+RNAcofold) for the target structures based on natural RNA-RNA interactions. As a result, MODENA+RactIP showed high design performance for the benchmark datasets.     

激光-电弧复合焊接过程中高频干扰的消除

激光-电弧复合焊接过程中,由于引孤产生的高频干扰了激光器的控制系统,造成了激光和电弧不能实现复合焊接.通过分析研究高频引弧对焊接电源和激光器的干扰途径,采取相应的措施,有效地消除了高频干扰问题,成功实现了激光和电弧之间的复合焊接.     

场效应晶体管弧焊逆变器可靠性研究

本文讨论了功率MOSFET晶体管弧焊逆变器的工作可靠性及其影响因素，并指出了弧焊逆变器设计中应注意的问题。     

CYCLIC DEFORMATION OF COARSE GRAINED POLYCRYSTALLINE PURE Al——Ⅱ.FRACTURE SURFACE MORPHOLOGY

SEM photos for very coarse grained and high ductile polycrystalline pure Al show followingcharacteristics:A few fracture sources are concentrated,the crack propagates in fan-shapenear them,and the fatigue striations are cyclic cleavage facets.Each striation consists of awide cleavage facet and a narrow cleavage stage.Those stages often blunt due to plasticdeformation.The fatigue striations are clear and continual,and distribute over whole zone ofstage Ⅱ crack propagation.Two kinds of fatigue striations form in different levels,areconjoined by a“twisted baked piece of pastry”band.The secondary crack along the fatiguestriations was observed frequently.Some of them have already developed into secondarymacrocracks and secondary fatigue striations were found clearly on secondary fracture sur-face.The fracture surface can be divided into two parts,initiation and propagation zone of thecrack,however,no statical-fracture zone was observed.The mechanism to form striationswas preliminarily discussed.     

手工电弧焊在带压补漏中的应用

压力容器和压力管道在生产过程中会出现泄漏，给生产过程带来影响或使生产中断，带压堵漏是保证生产正常进行的一种必要的技术手段。在此介绍了手工电弧焊带压堵漏的常用方法。     

火炮底板开裂分析

某公司购买的热轧钢板用于制作火炮底板,经数控火焰切割后,在过渡圆弧角处出现裂纹。采用化学成分分析、力学性能检测、金相检验、扫描电镜观察等方法对裂纹形成原因进行分析。结果表明:底板的化学成分和主要力学性能指标正常,原始组织粗大降低了材料性能。底板经火焰切割后组织变化较大,产生了粗大贝氏体和马氏体等不良组织,综合分析认为,底板断裂的主要原因是经数控火焰切割后组织应力过大和在过渡圆弧角处存在应力集中。通过采用火焰切割前对底板进行正火处理,提高了材料性能,有效避免了底板的开裂失效。     

不同添加剂对AgSnO2In2O3触头材料电性能的影响

采用内氧化法工艺制备了不含添加剂及分别含添加剂CuO或TeO2的3种AgSnO2In2O3触头材料。应用模拟继电器试验设备检测了这3种材料在AC230 V、25 A阻性负载条件下的电寿命、熔焊力、电弧能量、燃弧时间、质量侵蚀率等相关电性能参数,并对检测结果及试验后铆钉触头样品进行了分析。研究发现:与不含添加剂的AgSnO2In2O3材料相比,添加剂CuO对材料的电寿命影响不大,而添加剂TeO2明显提高了材料的电寿命;含添加剂的两种材料的熔焊力和电弧能量均有了不同程度的降低,但它们的质量侵蚀率却明显增加。     

基于多变量解耦控制的配电网单相接地故障集成化柔性消弧方法

随着静止无功补偿装置、柔性消弧装置、大功率逆变器等电力电子装备应用逐渐增多,配电网柔性化加快发展,但已有电力电子装备存在功能单一、成本高等问题.基于直流侧并接储能元件的直挂式级联H桥变流器,将多变量解耦控制方法与电流消弧方法相结合,实现柔性电力电子装备输出电流在dq0坐标系下的独立调节,使单套柔性电力电子装备同时集成配电网有功功率、无功功率双向流动控制,以及单相接地故障柔性消弧功能,有效提高电力电子装备的利用效率.理论分析以及功率控制和单相接地故障消弧建模仿真结果验证了所提方法的可行性.     

基于模型预测控制算法的多风储直流微电网分布式电压二次控制策略

针对含多组风储单元的直流微电网中蓄电池的电压优化控制问题,提出了一种基于模型预测控制算法的分布式电压二次控制策略.设计了一种多步长预测一致性模型作为电压预测模型,通过目标函数最小化求解预测系数,得到最优电压二次控制补偿量加入一次控制中,将传统一致性算法中比例积分控制器下的偏差调节问题转化为模型预测控制器下的电压跟踪问题进行求解,从而实现对直流母线电压动态响应的滚动优化.该方法有效解决了传统一致性算法下电压控制策略瞬态特性差和部分工况下存在控制误差等问题,并通过MATLAB/Simulink仿真平台搭建模型验证了不同工况下所提策略的有效性和优越性.