Topical delivery of paclitaxel for treatment of skin cancer

Context: Skin cancer represents the most growing types of cancer in human and ultraviolet radiation can be cited as one of the prime factor for its occurrence. Current therapy of skin cancer suffers from numerous side effects; for effective therapy, topical application of formulation of paclitaxel (PTX) can be considered as a novel approach.

Objective: The present study is an attempt to prepare formulation of solid lipid nanoparticles (SLN) of PTX for the effective treatment of various form of skin carcinoma.

Methods: The SLN were prepared by high-speed homogenization and ultrasonication method. The prepared SLN were characterized. The optimized PTX SLN were loaded in carbopol gel. The prepared gels were evaluated for its gelling properties and finally studied for in vivo anti-cancer efficacy and histopathological study.

Results: The particle size distribution was found to be in the range of 78.82–587.8?nm. The product yield (%) was found between 60% and 66% and showed a highest entrapment efficiency of 68.3%. The in vitro release of the drug from SLN dispersion was found to be biphasic with the initial burst effect, followed by slow release. SLN-loaded gel were subjected to permeability study and the results show steady-state flux (J_ss), permeability coefficient (K_p), and enhancement ratio were significantly increased in SLN-loaded gel formulation as compared with PTX-loaded gel. The histopathological study clearly reveals the efficacy of the SLN-F3 3G in the treatment of skin cancer.

Conclusion: The experimental formulations show controlled release of PTX and thus expected to show reduce dose-related side effects.     

Skin detection for single images using dynamic skin color modeling

Up-to-date skin detection techniques use adaptive skin color modeling to overcome the varying skin color problem. Most methods for tracking skin regions in videos utilize the correlation between contiguous frames. This paper proposes a new approach for detecting skin in a single image. This approach uses a local skin model to shift a globally trained skin model to adapt the final skin model to the current image. Experimental results show that the proposed method can achieve better accuracy. Two improvements for speeding up the processing are also discussed.     

实时视频中的快速人脸检测方法

提出一种实时视频中的快速人脸检测方法。采用DirectShow获取和回放视频帧,进行前处理。对所得彩色图像进行肤色分割,通过肤色的统计特性得到人脸候选区域,将该区域设置为感兴趣区域。运用基于局部扫描的AdaBoost算法对每个感兴趣区域进行检测。实验结果证明了该方法的有效性。     

实时可靠的检察院审讯监录系统

根据最高人民检察院对审讯全程进行同步监控录像的要求,研发检察院审讯监录系统。该系统采用基于3层C／S与B／S的混合体系架构,利用视频服务器、基于COM的DLL组件和ActiveX控件、伪实时机制,解决审讯同步录音录像、Web实时监控和双DVD同步实时刻录等关键问题。采用硬加密与基于角色的权限访问控制等安全机制保障系统可靠性。     

嵌入豁口磁芯的13.56MHzRFID读写器天线

本文针对天线线圈产生的磁场强度分布不均匀的现象,提出一种增强天线局部磁场强度的方案.首先,本文从理论出发解释了高频磁场的趋肤效应;其次,基于高频磁场的趋肤效应,提出往线圈中央添加开了豁口的金属磁芯,用以增强磁芯边缘和豁口位置的磁场强度;最后,通过三维电磁仿真软件AnsoftHFSS和MATLAB软件研究不同张角的豁口磁芯对环形天线的磁场强度的影响,旨在找出最优豁口的设计方案,对实际设计的13.56MHz RFID读写器天线具有一定的参考价值.     

基于巡逻小车的人脸遮挡异常事件实时检测

近年来,随着城市化进程的加快,银行、政府、学校等场所的安全越来越成为人们关心的问题,智能监控已成为目前的一个研究热点问题. 本文主要研究室内巡逻小车监控下,面部异常遮挡问题. 本文首先对监控视频进行前景提取;接着,基于提取的前景,进行肩部定位、头部区域椭圆拟合;然后通过肤色检测判断人脸区域;最后,通过Haar检测器检测人脸区域的眼睛和嘴巴,以此来判断是否存在异常遮挡行为. 实验结果表明,本文提出的算法能够实时、有效的检测出面部异常遮挡问题.     

利用轨迹模板匹配方法的实时动态手势识别

利用混合高斯模型进行运动检测,分割出运动前景,采用粒子滤波器结合皮肤椭圆模型进行手势跟踪,获得手势中心点运动轨迹,在此基础上提出利用轨迹模板匹配方法进行动态手势识别.该方法利用基本的几何和三角函数就能完成手势运动轨迹的定义和识别,不需要选择特征或训练样本.实验结果表明,该算法能够实现实时动态手势识别.