基于Logistic模型的P2P资源流行程度分析

为了解决目标资源数量增多而带来的监管成本过高的问题,提出一种基于Logistic模型的资源流行程度分析方法.利用该方法估计目标资源的流行程度,剔除流行程度低的资源,以此缩小监控范围,减少节点的部署数量.在Kad中对不同资源进行追踪,统计资源的共享节点数量,估计Logistic模型的参数,并进行曲线拟合.通过决策树建模得出,资源的共享节点数量和资源大小是影响该方法准确性的关键因素.     

考虑全柔性单元复杂变形的微位移放大机构刚度分析

提出一种考虑全柔性单元复杂变形的平面柔性机构刚度分析方法, 除将底座视为刚性单元外, 其余全部视为柔性单元, 然后根据力平衡方程即可得到机构整体刚度.该方法综合考虑了各柔性单元在各向的变形, 使得分析结果更接近实际情况, 同时避免了其他方法需要单独处理的柔性单元与刚性单元的位移协调问题, 可大大减少计算量.应用多种方法对一种微位移放大模块的刚度进行了研究.全柔性单元法的分析结果更接近ANSYS仿真结果, 并表明机构的整体刚度K与动力臂和阻力臂的比值有关, 两者相等时近似取得最小值, 为刚度与阻力臂的关系曲线拐点, 分析结果对给定刚度的杠杆放大机构参数设计具有重要意义.     

沥青路面铺筑温度场数值仿真模型

为确定一定环境下沥青混合料铺筑过程温度衰减规律, 对铺筑过程路面温度场的仿真模型进行了研究.采用非连续的随碾压次数而变的层厚、材料热物性和洒水散热条件, 连续的随温度而变的对流换热、辐射换热条件, 以及非均匀的底层初始温度场, 建立了一维仿真模型.通过变换几何模型及循环调用初始温度场的方法, 实现了非连续条件在连续场分析中的应用.由仿真模型验证, 本文模型可以在不同环境条件下实现铺筑过程温度场仿真.     

基于模糊物元模型的用频方案评估

提出了一种用频方案评估的方法,该方法建立了一套涵盖需求匹配性、方案经济性、方案抗扰性的用频方案评估指标体系,并利用基于模糊物元模型实现了多目标用频方案评估.仿真试验结果表明：该指标体系易于量化分析,采用模糊元方法直观地反映用频方案对不同目标的实现程度,能够较为客观地对用频方案进行评估.这对用频辅助决策有重要的应用价值.     

一种基于场强测量的辐射源定位方法

提出了一种基于车载监测系统移动测量场强值的未知辐射源定位方法.从消除电波非视距传播影响出发,利用场强中值算法和小波分析有效去除了多径快衰落噪声和地形遮蔽引起的慢衰落噪声.根据测试数据针对不同测试环境使用带有自适应偏差补偿因子的传播模型.通过遗传算法迭代计算残差的目标方程,较准确地实现了辐射源的定位.对算法进行计算机仿真与实测数据验证,证明了该定位算法的有效性.     

姜油树脂中β-倍半水芹烯的分离纯化

应用超临界二氧化碳萃取姜油树脂,选用乙醇-水作流动相,HPD-100大孔树脂作固定相分离出其中的烯类物质,并用高效液相色谱法进行跟踪检测确定含烯类的洗脱段。对比不同展开剂下烯类物质在硝酸银硅胶板上的层析效果,最终选用V_正己烷∶V_乙酸乙酯=95∶5的溶剂作流动相分离其中的β-倍半水芹烯。GC/MS检测结果表明,分别选用HPD-100大孔树脂和硝酸银硅胶作为固定相可以将姜油树脂中的β-倍半水芹烯很好的分离出来,其峰面积百分数达88.73%,收率为84.05%。通过进一步HPLC检测证明β-倍半水芹烯具有紫外吸收,其特征吸收波长为232 nm。      

Scatchard-Hildebrand热力学模型在预测PE中有害物质迁移分配系数的应用

为更加准确预测PE塑料中化合物向食品中迁移的分配系数。以PE中抗氧剂为代表,从大量文献中筛选PE中有害迁移物向食品模拟液迁移测试的可靠实验数据,将分配系数实验值F_exp与模型预测分配系数计算值F_sim对比分析,并对Scatchard-Hildebrand热力学模型进行实验校正,研究了温度（T）、迁移物分子量（M）和醇-水分配系数（log P）以及模拟液极性（ln Ps）与修正系数Ks(Ks=ln(F_sim/F_exp)的关系。结果表明除个别化合物因其分子结构特殊外,PE中化学物向脂肪类食品模拟液中迁移分配系数预测模型的修正系数Ks与M、log P、ln Ps均呈显著的线性相关性,得到修正后的Scatchard-Hildebrand热力学模型F’_sim=exp(V迁移物/RT·[φ_模拟液²(δ_迁移物-δ_模拟液)²-φ_聚合物²(δ_迁移物-δ_聚合物)²]-7.289-0.021M-1.317ln Ps+0.901log P),其在一定程度上能够预测PE中有害物质向脂肪类食品模拟物中迁移的分配系数。      

Capacity calculation for freight transportation network under comprehensive transportation system

为科学确定城市交通的发展规模,在分析关键交叉口转向能力的基础上,提出了基于超级节点的城市交通网络构建方法;考虑公交资源以及公交优先发展战略的因素,构建了城市交通发展规模与交通资源适应性的数学模型,并设计了基于反馈的免疫克隆算法. 以城市内某一区域为例对模型和算法进行验证,结果表明:模型及算法具有较好的实用性,能够为城市交通规划部门提供良好的决策支持.

     

Tissue Characteristics in Endodontic Regeneration: A Systematic Review

The regenerative endodontic procedure (REP) represents a treatment option for immature necrotic teeth with a periapical lesion. Currently, this therapy has a wide field of pre-clinical and clinical applications, but no standardization exists regarding successful criteria. Thus, by analysis of animal and human studies, the aim of this systematic review was to highlight the main characteristics of the tissue generated by REP. A customized search of PubMed, EMBASE, Scopus, and Web of Science databases from January 2000 to January 2022 was conducted. Seventy-five human and forty-nine animal studies were selected. In humans, the evaluation criteria were clinical 2D and 3D radiographic examinations. Most of the studies identified a successful REP with an asymptomatic tooth, apical lesion healing, and increased root thickness and length. In animals, histological and radiological criteria were considered. Newly formed tissues in the canals were fibrous, cementum, or bone-like tissues along the dentine walls depending on the area of the root. REP assured tooth development and viability. However, further studies are needed to identify procedures to successfully reproduce the physiological structure and function of the dentin–pulp complex.     

Truncated Analogues of a G-Quadruplex-Forming Aptamer Targeting Mutant Huntingtin: Shorter Is Better!

Two analogues of the MS3 aptamer, which was previously shown to have an exquisite capability to selectively bind and modulate the activity of mutant huntingtin (mHTT), have been here designed and evaluated in their physicochemical and biological properties. Featured by a distinctive propensity to form complex G-quadruplex structures, including large multimeric aggregates, the original 36-mer MS3 has been truncated to give a 33-mer (here named MS3-33) and a 17-mer (here named MS3-17). A combined use of different techniques (UV, CD, DSC, gel electrophoresis) allowed a detailed physicochemical characterization of these novel G-quadruplex-forming aptamers, tested in vitro on SH-SY5Y cells and in vivo on a Drosophila Huntington’s disease model, in which these shorter MS3-derived oligonucleotides proved to have improved bioactivity in comparison with the parent aptamer.