基于ARM7内核芯片网络通讯设计

为了实现对物理实验装置的远程监控和访问,将采用32位芯片技术和基于面向对象的网络Socket编程模式来实现控制系统的网络通讯.S3C4510B是三星公司针对网络应用而设计的CPU,本身带有100M网络控制器,而uClinux系统拥有完善的TCP/IP协议,故两者的结合为用户提供了强大的网络服务功能.本系统利用嵌入式网络技术可稳定可靠的实现数据的快速获取与给定.     

SVM分类器的风险评估算法研究

不论对分类问题还是回归问题,在构造实际可行的寻找决策函数f(x)的学习算法时,首先要有一个评价f(x)好坏的标准。而评价一个决策函数的性能时,一般是利用样本集估计其在检验集上推断时发生的错误率。给出了几个错误率估计算法,并详细分析了各估计函数的优缺点,最后的实验结果给出了从k-折交叉验证、RM-bounds和εα-estimator函数中预测出的测试错误率,进一步说明了不同的数据集可以选择不同的风险评估算法来预测出所选模型的最优参数。     

PIC16C74单片机应用与编程探讨

PIC系列单片机以其高性价比获得了日益广泛的应用,本文以PIC16C74为对象,对它的实际应用与编程中的一些具体问题做一探讨。     

基于变量技术和3S技术的精细农业信息处理

介绍基于变量技术和3S（DGRS,GIS,RS）技术的精细农业信息处理,并对其技术思想、数据采集、信息处理、决策实施及其技术支撑体系进行阐述,最后指出实施精细农业的必要性、应用及发展趋势。     

MCS-51单片机实验与开发系统

介绍利用ISP下载,设计的MCS-51单片机实验和开发系统,硬件结构和工作原理,并展示利用本系统完成的实验和单片机实现的开发功能.     

移动Agent在分布式信息检索中的研究

介绍了移动Agent技术与传统C/S方式的区别,给出了一个基于移动Agent的信息检索模型,分别利用移动A-gent和传统C/S两种方式实现了信息的检索,即在服务器存储的文档集合中进行关键词查询,然后筛选查询结果。对此论文进行了相应的实验研究,并给出了实验结果和对比结论。     

核素153Sm体素S因子特性的研究

基于体素S因子计算个体化病例的三维剂量是目前核医学研究的一个重要方向.153Sm是目前骨转移治疗常用的核素之一.本文利用EGS4蒙特卡罗程序包构建了基于体素的三维吸收剂量分布模拟程序,计算了不同情况下153Sm的S因子,探讨了介质成分和物理密度对S因子的影响.结果表明:1)不同物理密度对S因子有明显影响;2)在相同物理密度的情况下,不同介质对S因子的影响相对较小.计算结果为基于体素S因子计算核素治疗的三维剂量提供了参考,明确了在不考虑介质和物理密度差异时S因子的误差.     

The Evidence for Effective Inhibition of INa Produced by Mirogabalin ((1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic acid), a Known Blocker of CaV Channels

Mirogabalin (MGB, Tarlige^®), an inhibitor of the α₂δ-1 subunit of voltage-gated Ca²⁺ (Ca_V) channels, is used as a way to alleviate peripheral neuropathic pain and diabetic neuropathy. However, to what extent MGB modifies the magnitude, gating, and/or hysteresis of various types of plasmalemmal ionic currents remains largely unexplored. In pituitary tumor (GH₃) cells, we found that MGB was effective at suppressing the peak (transient, I_Na(T)) and sustained (late, I_Na(L)) components of the voltage-gated Na⁺ current (I_Na) in a concentration-dependent manner, with an effective IC₅₀ of 19.5 and 7.3 μM, respectively, while the K_D value calculated on the basis of minimum reaction scheme was 8.2 μM. The recovery of I_Na(T) inactivation slowed in the presence of MGB, although the overall current–voltage relation of I_Na(T) was unaltered; however, there was a leftward shift in the inactivation curve of the current. The magnitude of the window (I_Na(W)) or resurgent I_Na (I_Na(R)) evoked by the respective ascending or descending ramp pulse (V_ramp) was reduced during cell exposure to MGB. MGB-induced attenuation in I_Na(W) or I_Na(R) was reversed by the further addition of tefluthrin, a pyrethroid insecticide known to stimulate I_Na. MGB also effectively lessened the strength of voltage-dependent hysteresis of persistent I_Na in response to the isosceles triangular V_ramp. The cumulative inhibition of I_Na(T), evoked by pulse train stimulation, was enhanced in its presence. Taken together, in addition to the inhibition of Ca_V channels, the Na_V channel attenuation produced by MGB might have an impact in its analgesic effects occurring in vivo.     

Role of the Ubiquitin System in Stress Granule Metabolism

Eukaryotic cells react to various stress conditions with the rapid formation of membrane-less organelles called stress granules (SGs). SGs form by multivalent interactions between RNAs and RNA-binding proteins and are believed to protect stalled translation initiation complexes from stress-induced degradation. SGs contain hundreds of different mRNAs and proteins, and their assembly and disassembly are tightly controlled by post-translational modifications. The ubiquitin system, which mediates the covalent modification of target proteins with the small protein ubiquitin (‘ubiquitylation’), has been implicated in different aspects of SG metabolism, but specific functions in SG turnover have only recently emerged. Here, we summarize the evidence for the presence of ubiquitylated proteins at SGs, review the functions of different components of the ubiquitin system in SG formation and clearance, and discuss the link between perturbed SG clearance and the pathogenesis of neurodegenerative disorders. We conclude that the ubiquitin system plays an important, medically relevant role in SG biology.