Fundamental Clock of Biological Aging: Convergence of Molecular,Neurodegenerative, Cognitive and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

In humans, age-associated degrading changes, widely observed in molecular and cellular processes underly the time-dependent decline in spatial navigation, time perception, cognitive and psychological abilities, and memory. Cross-talk of biological, cognitive, and psychological clocks provides an integrative contribution to healthy and advanced aging. At the molecular level, genome, proteome, and lipidome instability are widely recognized as the primary causal factors in aging. We narrow attention to the roles of protein aging linked to prevalent amino acids chirality, enzymatic and spontaneous (non-enzymatic) post-translational modifications (PTMs ^SP), and non-equilibrium phase transitions. The homochirality of protein synthesis, resulting in the steady-state non-equilibrium condition of protein structure, makes them prone to multiple types of enzymatic and spontaneous PTMs, including racemization and isomerization. Spontaneous racemization leads to the loss of the balanced prevalent chirality. Advanced biological aging related to irreversible PTMs ^SP has been associated with the nontrivial interplay between somatic (molecular aging) and mental (psychological aging) health conditions. Through stress response systems (SRS), the environmental and psychological stressors contribute to the age-associated “collapse” of protein homochirality. The role of prevalent protein chirality and entropy of protein folding in biological aging is mainly overlooked. In a more generalized context, the time-dependent shift from enzymatic to the non-enzymatic transformation of biochirality might represent an important and yet underappreciated hallmark of aging. We provide the experimental arguments in support of the racemization theory of aging.     

邯钢高炉喷吹煤种的优化选择

通过对邯钢高炉喷吹用煤的化学成分、燃烧性能、输送性能、反应性和可磨性能的系统研究,认为高平秦城南煤可以作为邯钢高炉喷吹无烟煤的首选煤种,兴隆煤可以作为邯钢高炉喷吹贫煤或贫瘦煤的首选煤种.     

小电流接地选线技术的分析

结合国内小电流选线装置动作准确率低的实际情况,给出了目前小电流接地选线原理的分类和选线装置的使用现状,阐述了单相接地后系统中零序电流的流向特征,小电流接地选线中存在地问题和今后的研究方向.     

铜渣高温浮选药剂遴选与药剂制度优化研究

某铜渣硬度大、磨矿时间长,导致浮选矿浆温度过高以及浮选药剂分解,影响铜的回收,为此,对该铜渣进行了特性分析、捕收剂种类遴选及药剂制度优化研究.结果表明:以ZJ101为捕收剂,采用一粗三扫浮选流程,在ZJ101用量40+20+10+5 g/t条件下,可获得铜品位25.95％、铜回收率93.36％的指标,实现了高温体系下铜...     

A bidirectional feature selection method based on mutual information and redundancy-synergy coefficient

Featuresubsetselection(FSS)istoselectrele vantfeaturesandcastawayirrelevantandredundantfeaturesfromtheoriginalfeaturesetaccordingtoaFSSmeasure[1].IfafeaturesubsetsatisfiestheFSSmeas ureandhastheminimumsize,itisconsideredapartoftheoptimalfeaturesubset.Comp…     

矿用液压胶管、接头3D选型业务云服务平台

为提高矿用液压胶管、接头行业的智能化发展,提高行业竞争力,深度融合互联网与制造资源及能力,建立了“互联网+”专业云服务平台。详细论述了该平台的系统总体框架、功能结构和平台的关键技术。以接头3D选型为例进行应用验证,实现了3D选型业务服务,提高了供应商/客户协同设计效率,为类似产品和行业的发展提供了新的理念和相应的理论与数据支持。     

城市更新:由无序走向有序的过程——以浙江诸暨市老城区城市更新实践为例

简述了国内外城市更新的发展历程,评析了我国城市更新现状存在的各种不良倾向,并通过诸暨市老城区更新实践．总结出功能再植、交通重组、城市设计、经济分析、时序选择等应对问题的更新策略．期望对同类安全有所启示。     

一种新的基于直觉模糊集的作战决策算法

针对现有作战决策算法存在的不足,提出了一种新的基于直觉模糊集的作战决策算法.用直觉模糊值表示可行方案指标的不确定信息,综合考虑了方案满足指标的可能性、不满足的可能性和未知的可能性3个方面的因素,给出了直觉模糊决策矩阵的建立方法和可行方案优劣度排序方法.实例及实际应用证明了算法的有效性与可行性.     

一种自动识别最优阈值的图像分割方法

阈值分割是图像分割的常用方法,但至今没有一种对多数图像都适用的阈值选择的通用方法。本文基于图像的灰度级特征,以前景和背景最大程度地分开为判据,提出了一种简捷的自动识别最优阈值的图像分割方法。该方法对更多图像都可以给出最佳的闽值,达到较好的图像分割效果。     

基于粗糙集方法的水泥原材料选材算法研究

将粗糙集理论引入到水泥原材料的选材工作中,提出的方法以决策表作为主要工具,直接从实验样本集中导出选材规则,并揭示了选材实验数据信息的内在冗余性,通过例子表明了算法结果的有效性。