Targeting Casein Kinase 1 (CK1) in Hematological Cancers

The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. Among those, the most important are the functions of CK1s in the regulation of Wnt pathways, cell proliferation, apoptosis and autophagy. In this review we summarize the recent developments in the understanding of biology and therapeutic potential of the inhibition of CK1 isoforms in the pathogenesis of chronic lymphocytic leukemia (CLL), other non-Hodgkin lymphomas (NHL), myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and multiple myeloma (MM). CK1δ/ε inhibitors block CLL development in preclinical models via inhibition of WNT-5A/ROR1-driven non-canonical Wnt pathway. While no selective CK1 inhibitors have reached clinical stage to date, one dual PI3Kδ and CK1ε inhibitor, umbralisib, is currently in clinical trials for CLL and NHL patients. In MDS, AML and MM, inhibition of CK1α, acting via activation of p53 pathway, showed promising preclinical activities and the first CK1α inhibitor has now entered the clinical trials.     

Colloidal processing of Al2O3-doped zirconia ceramics with CaO–P2O5–SiO2 glass as additive

Well-dispersed concentrated aqueous suspensions of Al₂O₃-doped Y-TZP (AY-TZP), AY-TZP with 5.4 vol% of CaO–P₂O₅–SiO₂ (CaPSi) glass (AY-TZP5) and 10.5 vol% CaPSi glass (AY-TZP10), with ammonium polyacrylate (NH₄PA) dispersant were prepared to produce slip cast compacts. The rheological properties of 35 and 40 vol% slips were studied. The densification, microstructure as well as hardness and fracture toughness were investigated as a function of CaPSi glass content at 1300°C-1500°C. The optimum NH₄PA concentration of 35 vol% AY-TZP5 and AY-TZP10 slips at pH ~9 was found to be about 43% and 67% greater than that of AY-TZP slips; this behavior was related to the greater amounts of Ca²⁺ ions leached out from the CaPSi glass surface. The viscosity of stabilized 40 vol% slips with NH₄PA attained a minimum value at 5.4 vol% CaPSi glass addition, and resulted in a more dense packing of cast samples. AY-TZP5 can be sintered at a lower temperature (1300°C) compared to that of AY-TZP. AY-TZP5 exhibited a fine microstructure of tetragonal ZrO₂ (grain sizes below 0.3 µm), and ZrSiO₄–Ca₂P₂O₇ particles homogeneously distributed within the zirconia matrix. It presented similar fracture toughness and a slightly lower hardness compared to those of AY-TZP.     

Postsynthesis of hierarchical core/shell ZSM-5 as an efficient catalyst in ketalation and acetalization reactions

Hierarchical core/shell Zeolite Socony Mobil-five (ZSM-5) zeolite was hydrothermally postsythesized in the solution of NaOH and diammonium surfactant via a dissolution-reassembly strategy. The silica and alumina species were firstly dissolved partially from the bulky ZSM-5 crystals and then were in situ reassembled into the MFI-type nanosheets with the structure-directing effect of diammonium surfactant, attaching to the out-surface of ZSM-5 core crystals. The mesopores thus were generated in both the core and shell part, giving rise to a micropore/mesopore composite material. The micropore volume and the acidity of the resultant hybrid were well-preserved during this in situ recrystallization process. Possessing the multiple mesopores and enlarged external surface area, the core/shell ZSM-5 zeolite exhibited higher activity in the ketalation and acetalization reactions involving bulky molecules in comparison to the pristine ZSM-5.     

聚对亚苯基苯并二(噁)唑合成新路线及其制备新技术

为进一步提升聚对亚苯基苯并二噁唑（PBO）材料的性价比并促进其工业化,研究了以4,6-二硝基间苯二酚为原料,先选择还原制得4-氨基-6-硝基间苯二酚盐酸盐,进而与对甲氧羰基苯甲酰氯进行缩环合获得苯并噁唑化合物,再催化加氢合成AB型PBO新单体2-(对甲氧羰基苯基)-5-氨基-6-羟基苯并噁唑（MAB）,最后自缩聚反应制备PBO的新路线和新方法.结果表明：该方法具有原料易得、反应条件缓和、中间体稳定等新技术优势.合成的PBO树脂总收率达64%、特性黏数η>10 dl&#8226;g^-1,新单体MAB的纯度>98%,具有稳定性优异和缩聚基团完全等当比等性质,以及均缩聚时间<20 h和过程易操作等技术特点,均为4,6-二氨基间苯二酚（DAR）共缩聚路线所难以比拟的.其综合经济性优于三氯化苯经DAR共缩聚的工业化路线,有望发展成易于实施PBO产业化的一项新技术.     

5-(4-羟基苄叉)-噻唑烷-2,4-二酮的合成

5-(4-羟基苄叉)—噻唑烷-2,4-二酮是抗糖尿病药的关键中间体,本文以硫脲为原料,经闭环、中和、水解、缩合4步反应合成得到目标物,总收率40%。     

变压吸附制纯氧过程阀系数的优化控制

利用电路网络模型,对变压吸附制纯氧阀系数进行优化控制,在碳分子筛为第一级吸附,5A分子筛作为二级吸附工艺中,可得到浓度为99.06%,回收率为28.4%的氧气产品,从而提高了氧气的回收率,增加了单位吸附剂的生产能力,节省了动力消耗.     

关于对矿山5G网络的安全接入的研究

本文对矿山5G网络的安全接入的重要性进行了分析,从矿山5G网络基础设施的安全方案、支持数据机密性、权限管理以及敏感信息保护四个方面提出了矿山5G网络的安全接入措施。     

IBNAD:一种基于交互的5G核心网网络功能异常检测模型

现有 5G(5th Generation Mobile Communication Technology)核心网异常检测主要基于信令流量深度解析, 但较少利用核心网网络功能交互关系的作用。针对上述问题, 提出一种基于交互的 5G 核心网网络功能异常检测模型。首先, 该模型以行为分析为驱动, 基于信令流量和网络功能注册数据提取多维属性, 通过行为画像来表征网络功能行为模式, 并采用集成学习算法RFECV(Recursive Feature Elimination with Cross-Validation)进行属性特征选择, 降低特征维度的同时筛选出与区分网络功能行为模式高度相关的属性特征。然后, 模型基于网络功能交互关系对核心网进行图建模, 建模后的图数据融合了网络功能属性信息和交互信息。最后, 模型通过基于空间域的图卷积网络聚合邻域节点属性信息和结构信息来融合行为模式特征, 新生成的节点表示用于分类, 从而将核心网网络功能异常检测问题转化为图节点分类问题。通过在 free5GC 仿真平台上采集数据, 并在搭建的异常检测系统中的实验表明, 该模型的异常检测性能优于基于属性特征分析的传统机器学习模型、基于结构特征分析的图嵌入模型及部分 5G 核心网异常检测模型。10%数据集作为训练集时, 所提模型的准确率比支持向量机模型提高 6.6%, 比Struc2vec 模型提高 13%, 比深度神经网络模型提高 8%。     

新型液体燃料5-乙氧基甲基糠醛的催化转化研究进展

5-乙氧基甲基糠醛（5-ethoxymethylfurfural,EMF）是一种替代化石能源的潜在液体燃料,近年来EMF的合成引起了国内外科研人员的广泛关注。本文综述了EMF转化合成的生物质原料、均相和非均相催化转化体系的研究进展,对比了单相与双相溶剂的作用效果,以期为EMF的合成与生物质转化利用提供科学依据。最后,对EMF的合成策略及工业化生产进行展望。     

基于 LeNet5like 的迁移学习风电机组叶片覆冰故障诊断研究

针对海上风电场和高海拔地区风机机组的叶片覆冰故障模型精度低、建模速度慢等问题,提出一种基于 LeNet5like 的 迁移学习风电机组叶片覆冰故障诊断方法。 首先,整合监控和数据采集系统的记录数据与风机覆冰情况进行预处理,建立训练 数据集;其次,基于改进后的 LeNet5like 网络构建覆冰故障诊断模型,提取数据集中多变量间的相关性特征信息;然后,经网络 参数微调迁移学习对模型进行训练,实现对其他风机覆冰故障诊断模型的快速建立;最后,经实验验证,该模型覆冰故障诊断准 确率为 98. 90% ,较无迁移模块网络训练时间缩短 28 s,提升约 15. 91% ,验证了基于 LeNet5like 的迁移学习风电机组叶片覆冰 故障诊断方法的精确性和快速性。