Comparative Assessment of Complex Stabilities of Radiocopper Chelating Agents by a Combination of Complex Challenge and in vivo Experiments

For ⁶⁴Cu radiolabeling of biomolecules to be used as in vivo positron emission tomography (PET) imaging agents, various chelators are commonly applied. It has not yet been determined which of the most potent chelators—NODA‐GA ((1,4,7‐triazacyclononane‐4,7‐diyl)diacetic acid‐1‐glutaric acid), CB‐TE2A (2,2′‐(1,4,8,11‐tetraazabicyclo[6.6.2]hexadecane‐4,11‐diyl)diacetic acid), or CB‐TE1A‐GA (1,4,8,11‐tetraazabicyclo[6.6.2]hexadecane‐4,11‐diyl‐8‐acetic acid‐1‐glutaric acid)—forms the most stable complexes resulting in PET images of highest quality. We determined the ⁶⁴Cu complex stabilities for these three chelators by a combination of complex challenge and an in vivo approach. For this purpose, bioconjugates of the chelating agents with the gastrin‐releasing peptide receptor (GRPR)‐affine peptide PESIN and an integrin α_vβ₃‐affine c(RGDfC) tetramer were synthesized and radiolabeled with ⁶⁴Cu in excellent yields and specific activities. The ⁶⁴Cu‐labeled biomolecules were evaluated for their complex stabilities in vitro by conducting a challenge experiment with the respective other chelators as challengers. The in vivo stabilities of the complexes were also determined, showing the highest stability for the ⁶⁴Cu–CB‐TE1A‐GA complex in both experimental setups. Therefore, CB‐TE1A‐GA is the most appropriate chelating agent for *Cu‐labeled radiotracers and in vivo imaging applications.     

EXTRACTION OF URANYL IONS BY SYNERGISTIC MIXTURES OF THENOYLTRIFLUOROACETONE AND MACROCYCLIC DONORS

A linear polyether, 1, 13-bis[8-qulnoly]-l,4,7,10,13-pentaoxa-trldecane (K-5) and an aza-crown ether, 4,13-didodecyl-1,7,10,16-tetraoxadiazacyclooctadecane (K22DD) when combined with thenoyltrlfluoroacetone (HTTA) have been shown to exhibit a synergistic effect on the extraction of uranyl ion. The effects of the addition to the organic phase of K-5, K22DD, and tert-butylcyclohexyl-15-crown-5 (15-C-5) on the extraction of UO₂ ⁺² by HTTA in chloroform from 0.5 M NaNO₃ at 25°C have been measured. The results indicate the extraction is enhanced by the formation of an adduct, UO₂(TTA)₂S for K-5 and K22DD. No enhancement of the extraction was seen with the crown ether. The organic phase stability constants for both K-5 and K22DD were evaluated and found to be similar in magnitude. These results suggest that the major factor in the formation of the synergistic adduct is the presence of the nitrogen atom in the synergist.     

雷64块S3中储层沉积相标志分析

为了确定雷64块S3中储层沉积体系,采用薄片鉴定、重矿物鉴定等手段,对目的层砂岩碎屑母岩类型及物源特征进行了分析;综合录井资料、测井资料对目的层进行地层对比划分,分析了储层的空间展布;综合岩石特征、电学特征对单井的目的层沉积相进行分析。研究表明,雷64块S3中储层为重力流环境的水下扇沉积体系。     

基于功能和数据划分的H.264并行解码算法

针对H.264视频解码算法的并行模块选择、划分及解码速度优化等问题,面向TilePro64多核平台,提出一种可扩展的H.264并行解码算法。对该算法的内部功能模块进行整合和划分,根据核间数据的依赖关系,动态分配功能模块及优化算法并行效率。实验结果表明,该算法在解码效率、多核并行程度、解码时延等方面均有较好性能,相比传统并行解码算法,其并行加速比提高约25%。     

In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64Cu-PET/CT Imaging in Breast Cancer Model

An improved glucose-chelator-albumin bioconjugate (GluCAB) derivative, GluCAB-2^Mal, has been synthesized and studied for in vivo ⁶⁴Cu-PET/CT imaging in breast cancer mice models together with its first-generation analogue GluCAB-1^Mal. The radioligand works on the principle of tumor targeting through the enhanced permeability and retention (EPR) effect with a supportive role played by glucose metabolism. [⁶⁴Cu]Cu-GluCAB-2^Mal (99 % RCP) exhibited high serum stability with immediate binding to serum proteins. In vivo experiments for comparison between tumor targeting of [⁶⁴Cu]Cu-GluCAB-2^Mal and previous-generation [⁶⁴Cu]Cu-GluCAB-1^Mal encompassed microPET/CT imaging and biodistribution analysis in an allograft E0771 breast cancer mouse model. Tumor uptake of [⁶⁴Cu]Cu-GluCAB-2^Mal was clearly evident with twice as much accumulation as compared to its predecessor and a tumor/muscle ratio of up to 5 after 24 h. Further comparison indicated a decrease in liver accumulation for [⁶⁴Cu]Cu-Glu-CAB-2^Mal.     

HD64F／3687芯片在低成本变频器中的应用

在简要介绍HD64F/ 3687芯片的结构及特点的基础上, 将此种芯片应用于低成本变频器中, 使用其内部定时器通过软件生成所需的SPWM波形并由此探讨了HD64F/3687在变频调速中的应用。此芯片在变频调速系统中方便易用,具有可简化硬件电路,降低变频器生产成本等优点。     

一种定制的出口退税远程申报邮件收发系统

在TCP/IP协议上 ,定制一套SMTP、POP3、ADDRESSBOOK协议 ,从而实现了定制的电子邮件收发系统     

COSIX64设备驱动程序开发技术综述

该文论述了在Alpha系列计算机以及COSIX64操作系统平台下,开发基于EISAISA总线专用板的驱动程序的技术路线、技术难点及其解决方法。总结了开发COSIX64驱动程序的一般步骤。     

基于ARM的CIS系统高速数据采集实现

首先简单介绍了一些高速数据采集方法的优缺点。然后简单介绍了ATMEL公司生产的32位ARMRISC处理器AT91SAM7S64的结构与特点,并利用AT91SAM7S64的ADC和PDC实现90E卷接机组中CIS(烟支检测系统)的高速数据采集。给出了硬件连接图与相关的程序。     

TMS320C64x系列DSP的UTOPIA接口设计与实现

ATM传输是宽带综合业务数字网的重要技术,为使DSP能接入ATM系统,利用TMS320C64x特有的UTOPIA接口构建了一个ATM系统的从设备.介绍了UTOPIA接口基本的发送和接收操作流程,设计了与主控制器MPC8260连接的接口电路,重点探讨了UTOPIA从设备端的参数设置要点,并给出部分程序段代码.