Effect of bioadhesive polymers,sodium salicylate,polyoxyethylene-9-lauryl ether,and method of preparation on the relative hypoglycemia produced by insulin enteric-coated capsules in diabetic beagle dogs

The hypoglycemic effect of oral insulin capsules coated with pH-dependent Eudragit® S100 and containing various absorption promoters was studied in hyperglycemic beagle dogs. The absorption enhancers used were bioadhesive polymers, sodium salicylate, and non-ionic surfactants. A comparative study of the bioadhesive polymers, polycarbophil (PC), hydroxypropyl methylcellulose (HPMC), and carbopol 934 in insulin-coated capsules revealed no significant difference between the insulin capsules containing these polymers, giving relative hypoglycemia (RH) values ranging from 4.3±2.3% to 6.5±5.1%. It was also found that the method of preparation of the mixture of the bioadhesive polymer with insulin either by physical mixing or freeze-drying did not affect the RH values obtained. Sodium salicylate, when used in insulin enteric-coated capsules (50 mg) mixed with insulin as a physical mixture, or prepared by wet granulation using 10% polyvinyl pyrollidone (PVP), or by freeze-drying, produced RH values ranging from 7.3±2.9% to 9.4±3.7%. When sodium salicylate (100 mg) was used with insulin in freeze-dried granules an RH value of 10±2.6% was produced. As the dose of insulin increased from 6 to 9 U/kg, the area under curve (AUC) of the enteric-coated capsules containing 50 mg sodium salicylate increased from 73.2±27.8% to 121.4±102.7% reduction, but the RH did not change significantly. Insulin capsules containing polyoxyethylene-9-lauryl ether (POELE) used in its optimum concentration (2%), found in these experiments, produced RH of 9.5±6.8% when prepared as granules by wetting with a few drops of absolute alcohol in the presence of PC (50 mg). Insulin capsules containing lower (1%) or higher (3%) concentrations of POELE and prepared with PC, 50 mg by wet granulation produced lower RH of about 6%. The enteric-coated oral insulin capsules containing insulin (6 or 9 U/kg) and sodium salicylate (50 mg) as an absorption promoter, together with the bioadhesive polymer polycarbophil (50 mg), and prepared either by wet granulation using ethanol or by freeze-drying, are the best formulations to be used. They achieved a reduction in plasma glucose levels of about 25-30% and RH of about 10%. Also insulin (9 U/kg) capsules containing 2% POELE produced a 28% reduction in plasma glucose levels and RH of 9.6±6.8%.     

Application of hydroalcoholic solutions of formaldehyde in preparation of acetylsalicylic acid gastro-resistant capsules

Enteric coating of hard gelatin capsules by application of hydroalcoholic solutions of formaldehyde was studied and developed in accordance with previous publications. It is possible to affirm that this coating constitutes a simple, stable, reproducible, and inexpensive method, being a valid alternative to those which have been proposed. The aim of the present investigation is the preparation of acetylsalicylic acid gelatin capsules with good conditions of gastro-resistance and enteros solubility.     

Structural Color Palettes of Core–Shell Photonic Ink Capsules Containing Cholesteric Liquid Crystals

Photonic microcapsules with onion‐like topology are microfluidically designed to have cholesteric liquid crystals with opposite handedness in their core and shell. The microcapsules exhibit structural colors caused by dual photonic bandgaps, resulting in a rich variety of color on the optical palette. Moreover, the microcapsules can switch the colors from either core or shell depending on the selection of light‐handedness.     

软胶丸干燥特性的系统分析和研究

针对现行软胶丸干燥工艺中存在的周期长、耗能大且干燥质量难以保证等问题，本文系统地分析了影响软胶丸干燥过程的各种因素，并用试验方法获得了软胶丸的干燥特性，提出了软胶丸的干燥特性。提出了软胶丸干燥的最佳方式。     

丁玲的转型——论丁玲延安时期作品风格的转变

丁玲延安时期的转型,表现在文本中,是文学风格的转变。文学作品的风格是作家创作个性在一系列作品中所表现出来的鲜明的艺术特色,包括作家的风格和作品的风格。一般来说,一个作家的作品风格是一致的,是贯通的,而丁玲作品的风格却在延安时期出现了和早期截然不同变化,标志着丁玲从早期的一个纯粹追求艺术个性的作家在延安时期转型为一个国家摇旗呐喊的革命者。     

二氟一氯乙烷工艺设计方案改进

介绍二氟一氯乙烷的用途和生产方法 ,通过采用仿真研究的手段 ,结合工程设计的实际 ,提出改进生产工艺的措施 ,使工艺设计方案更加合理 ,也能节省大量投资。     

高效液相色谱法测定明胶胶囊中11种合成色素的方法研究

建立一种用高效液相色谱(high performance liquid chromatography,HPLC)同时测定明胶胶囊中的11种合成色素的分析方法。样品经木瓜蛋白酶60℃水解30 min后,以CAPCELL PAK C₁₈柱(4.6 mm×250 mm,5 μm)为分析柱,甲醇-乙腈(1:1)和15 mmol/L乙酸铵为流动相,梯度洗脱进行分离,以二极管阵列检测器检测,检测波长450(柠檬黄、喹啉黄)、520(新红、苋菜红、胭脂红、日落黄、诱惑红、偶氮玉红、赤藓红)和620 nm(靛蓝、亮蓝)。结果表明:11种合成色素在0~100 μg/mL浓度范围内线性关系良好,相关系数均大于0.999,方法检出限为0.3~2.5 mg/kg,回收率在79.1%~119.3%之间。该方法操作简便,灵敏度高,分离效果好,能实现11种色素的同步测定,适用于明胶胶囊中合成色素的检测分析。     

共聚胶囊化纳米SiO2的研究

经含有不饱和双键的硅烷偶联剂处理后，纳米SiO2表面的极性有所减弱，同时与活性单体的相容性得到了增强，再与活性单体进行共聚反应，在其表面形成聚聚胶囊，采用热重分析仪（TG）、傅立叶红外测试仪（FTIR）、透射电子显微镜（TEM）、激光粒度分析仪（LGA）等对纳米SiO2的改性效果进行表征，试验结果表明：活性单体成功地接枝到纳米SiO2的表面，形成了胶囊外壳，其接枝率为32％，并使纳米SiO2在有机溶剂中的分散稳定性得到了明显的改善．     

人参茸芝胶囊的质量控制研究

目的建立人参茸芝胶囊中人参、灵芝孢子粉的定性鉴别和标志性成分人参皂苷和灵芝酸A含量测定的方法。方法用薄层色谱法(thin layer chromatography,TLC)定性鉴别人参茸芝胶囊中人参、灵芝孢子粉;用高效液相色谱法(high performance liquid chromatography,HPLC)测定人参皂苷和灵芝酸A的含量。结果薄层鉴别荧光斑点清晰,分离度好,阴性对照无干扰;人参皂苷在0.5~50μg范围内呈良好的线性关系,平均回收率在98.53%~102.53%之间,相对标准偏差(RSD)在0.84%~1.83%之间;灵芝酸A的线性范围0.0006~0.06mg/m L(r2=0.9998),平均回收率为98.80%,RSD为0.89%。结论所建立的人参、灵芝孢子粉定性鉴别、标志性成分人参皂苷和灵芝酸A定量检测方法可用于人参茸芝胶囊的质量控制。     

大兴安岭东南缘成矿集中区成矿演化特征与找矿潜力

本区为叠加在槽、台接合部偏槽区上的太平洋型大兴安岭构造岩浆岩区的中亚带。地处深大断裂夹持区和上地幔构造变异带上。三层构造层断裂系构成等距菱格网状构造系统。太平洋构造岩浆活动在区域上的推移和区域地球化学场制约区域金属分带。本区具深源浅成－超浅成斑岩铜多金属成矿系列特征。为待揭开的大型以上规模的燕山期斑岩系列成矿潜在区。