两种不同提取方法所得莪术油的成分对比分析

利用气相色谱、气相色谱-质谱联用分析技术,对水蒸气蒸馏和超临界CO2萃取两种不同方法提取得到的莪术油化学成分进行分析鉴定,分别从中分离出60余和90余个组分,并确认了其中50多种化学成分,得到鉴定的组分峰面积占总馏出峰面积的90%以上。根据成分鉴定结果,对不同提取方法所得莪术油的主要化学成分进行比较分析。两种不同提取方法获得的莪术油组分不完全相同,含量也不尽相同,但主要化学成分基本一致,超临界CO2萃取的莪术油所含化学成分较多且相对分子质量较大的重组分较多。同时,对不同方法提取的莪术油中莪术醇等主要特征成分,采用薄层色谱、气相色谱、质谱进行分析测定。研究结果可为莪术油的开发与质量控制提供科学依据。     

灵莲花颗粒治疗围经期综合征临床观察研究

通过治疗组360例,对照组120例按照临床方案进行治疗,对比分析两组治疗效果,观察灵莲花颗粒对治疗围经期综合征的临床疗效。结果表明,经过治疗组与对照组4周的治疗,治疗组痊愈率及总有效率优于对照组,两组均未发生严重不良反应。灵莲花颗粒在治疗更年期综合症方面得到满意的疗效,不良反应发生率低,值得临床推广。     

武汉东湖休养所设计分析

东湖休养所是冯纪忠先生早年重要的设计作品。简述了东湖休养所的建造过程,指出它的建设得益于陶铸的关注,并对岭南现代建筑庭园产生了重要影响。从现代主义的建筑精神和人与自然的关系对东湖休养所进行设计分析,指出东湖休养所的空间组合和建构体现了现代主义建筑的精神,冯先生在德国接受的现代主义建筑教育是其渊源,而东湖休养所的建筑与户外环境的融洽关系依然体现了具有东方特色的和谐共处理念,这又源于冯先生对中国传统文化的熟稔。     

洗衣凝珠的分析检测

洗衣凝珠是近年来发展迅猛的一类全新的洗涤用品,具有使用便捷、去污力强、多功能性等诸多优点,备受消费者青睐.尽管洗衣凝珠发展快速,但是其分析检测方法的发展则相对较为滞后.洗衣凝珠的检测通常是采用相近产品的分析方法,并无专门性规定.即将执行的行业标准QB/T 5658《洗衣凝珠》首次对洗衣凝珠产品的分析检测方法进行全面系统...     

Time domain 1H NMR as a new method to monitor softening of gelatin and HPMC capsule shells

Defined mechanical properties are an essential requirement for any pharmaceutical dosage form and this is particularly important in the case of liquid-filled capsules. Changes in the mechanical properties may be induced by exposure of the capsules to humidity or by a shift of the water equilibrium that typically occurs when hydrophilic or amphiphilic fill masses are used, for example, in self-emulsifying drug delivery systems. This study aims to characterize the softening of empty hard gelatin and hydroxypropyl methylcellulose (HPMC) capsules by means of mechanical tests, a Bareiss hardness test, and a stiffness test using a texture analysis method. A benchtop time domain NMR method is applied in addition to characterize the physico-chemical state of water in the capsule shells and to correlate this with the results of the mechanical tests. Hardness and stiffness measurements resulted in corresponding values, showing a softening for both capsule materials in a humid environment, which was most pronounced beyond 60% relative humidity. The capsules made of gelatin exhibited in general higher stiffness and hardness values compared to the HPMC capsules. The physico-chemical state of water in the capsule shells, as probed by a time domain NMR method, was interpreted in terms of a population balance model. Three different water populations were identified that differ in their molecular mobility, as indicated by their characteristic spin-lattice relaxation times, T1. The most loosely bound water fraction dominated in the capsule shells in the range beyond 60% relative humidity. Numerical correlation of the data led to a heuristic equation between the NMR-derived fraction of loosely bound water in the capsule shells and their mechanical stiffness and hardness. Adequate models were obtained for both capsule types, gelatin, and HPMC. Mechanical measurements of pharmaceutical capsules are generally destructive and time consuming. Testing is usually performed in an analytical laboratory, off-line from the manufacturing process, and involves only a small number of samples. Based on the here presented correlation between mechanical stiffness measurements and benchtop time domain NMR data, the latter method may be used as a nondestructive alternative for mechanical testing. This study also opens the possibility to investigate liquid-filled capsules and to establish a process analytical technology (PAT) during manufacturing.     

火焰原子吸收光谱法测定三硅酸镁中镁的含量

目的:建立三硅酸镁中镁的含量测定方法。方法:样品微波消解处理后,火焰原子吸收光谱法测定样品中镁的含量。结果:镁在0.05~0.4mg/L范围内线性关系良好,相关系数为0.9995;回收率在98.4%~102.9%,RSD为1.5%。结论:该方法简单、快速、准确;能很好地用于三硅酸镁中镁的质量控制。     

An efficient architecture for accumulator-based test generation of SIC pairs

Research conducted over the years has shown that the application of single input change (SIC) pairs of test patterns for sequential, i.e. stuck-open and delay fault testing is extremely efficient. In this paper, a novel architecture for the generation of SIC pairs is presented. The implementation of the proposed architecture is based on Ling adders that are commonly utilized in current data paths due to their high-operating speed. Since the timing characteristics of the adder are not modified, the presented architecture provides a practical solution for the built-in testing of circuits that contain such adders.     

Dissolution and Solidification of Aluminum Capsule in Production of Mo-99 by Sublimation from Neutron-Irradiated UO2

A technique, based on the correlation analysis of signal pulses in time sequence, is proposed to determine the production rate of the pseudo multi-pulse in Geiger-Mueller (GM) counter. With a multi-channel scaler initiated by a signal pulse, subsequent pulses are recorded in sequence. The production of the multi-pulse increases the counting probability immediately after the initiation. By examining the deviation of the measured probability from the ideal counting probability, the production rate and the average lag time to produce the multi-pulse can be determined. By the use of the present technique, the production rate and the average lag time were obtained for the various GM tubes. These results indicate that the consumption of the quench gas results in a significant increase in the production rate but little variation in the lag time, and that the lag time strongly depends on the tube diameter.     

可持续的塑料降解产品设计研究

目的塑料制品污染在人们的生活中随处可见,但有关塑料制品的前沿应用普及度并不高。在强调新型可降解塑料和人们日常行为转变的同时,也要认识到不可降解塑料仍旧存在,要明确如何处理不可降解塑料和利用残留物,旨在探究塑料降解新的可能性。方法通过多方资料收集类比,得出适用于消化动物体内塑料的微生物处理办法,以信天翁为设计实践目标,结合TRIZ理论,完成产品设计、绘制相关机械流程图。结论未来塑料制品污染可以通过发明新型可降解塑料的方式解决,现在塑料制品的扩散可以通过法律法规去限制,过去的塑料制品带来的污染和伤害同样可以用新的设计方案去解决。     

Self‐Assembled Biomimetic Capsules for Self‐Preservation

The inorganic semiconductor is an attractive material in sewage disposal and solar power generation. The main challenges associated with environment‐sensitive semiconductors are structural degradation and deactivation caused by the unfavorable environment. Here, inspired by the pomegranate, a self‐protection strategy based on the self‐assembly of silver chloride (AgCl) particles is reported. The distributed photosensitive AgCl particles can be encapsulated by themselves through mixing aqueous silver nitrate and protic ionic liquids (PILs). A probable assembling mechanism is proposed based on the electrostatic potential investigation of PILs cations. The AgCl particles inside the shell maintain their morphology and structure well after 6 months light‐treatment. Moreover, they exhibit excellent photocatalytic activity, same as newly prepared AgCl particles, for degradation of methyl orange (MO), neutral red (NR), bromocresol green (BG), rhodamine B (RhB), Congo red (CR), and crystal violet (CV).