Structural characterization and immunostimulatory activity of a novel protein-bound polysaccharide produced by Hirsutella sinensis Liu,Guo, Yu & Zeng

HS002-II, a novel protein-bound polysaccharide with 44 kDa molecular weight, was fractionated from submerged cultures of Hirsutella sinensis Liu, Guo, Yu & Zeng by DEAE-Sepharose and Sephacryl S200 chromatography. Based on the results of infrared spectroscopy, high performance liquid chromatography, methylation, amino acid analysis, NMR spectroscopy and atomic force microscopy, the polysaccharide moieties of HS002-II mainly contained a long backbone of (1 → 3)-linked α-d-ribofuranosyl units (1 → 4)-linked α-d-xylopyranosyl units and (1 → 4)-linked β-d-glucopyranosyl units, which was substituted at C-6. The two branches were β-d-mannopyranosyl residues and β-d-galactopyranosyl residues terminated with α-l-arabinopyranosyl residues, respectively. HS002-II consisted of 57.9% polysaccharide and 42.1% protein with the existence of N-type carbohydrate–protein linkage. In terms of the pro-inflammatory cytokines assay (NO, TNF-α, IL-1β and NF-κB) using murine macrophages cell line (RAW264.7), HS002-II exhibited significant immunomodulatory activity by stimulating the IκB-NF-κB pathway.     

一个求解n皇后问题的演化策略

基于郭涛算法多目标优化思想，采用分解多目标和二次演化的方法。对具有离散性的n皇后问题进行求解，测试表明，该算法对搜索空间不具有局域性的离散问题，具有良好效果。     

Eu^2＋激活的碱土铝酸盐长余辉发光材料的研究现状

简要介绍了Eu^2 作为碱土铝酸盐激活剂的荧光特性和影响材料发光特性的因素。综述了国内外在制备技术和机理方面的研究现状和该类材料的应用现状。最后指出了目前材料研究中存在的问题，并对今后的研究方向作了展望。     

园林、风景与城市：近代城湖关系 变迁下西湖湖上园林的演进与转型

与传统的城市私家园林不同,杭州西湖湖上园林一直在一个更为复杂和动态的城湖大环境中发展与演化。民国初年"西湖入城",使城湖空间不再隔绝,也加剧了园林、风景、城市互为影响、互为转化,最终演变成为一个新的有机整体。以郭庄及西泠印社2个具有代表性的湖上园林为分析对象,通过辨析园林中建筑与空间的变化,以及相应的公共游览与使用方式变迁,试图阐明当一个复杂的依托环境发生变化时,其中的园林是如何适应、演化及转变,而这一变化又是如何在园林空间格局、园林中心空间及园林空间的公共性使用3个层面来得以具体体现的。在这一演变过程中,西湖湖上园林也逐渐摆脱单一的园林身份,发展为园林、公共风景与城市生活空间的综合体,这最终造就了西湖湖上园林不同于其他江南传统园林的独特性与重要性。     

高酯化酶活性红曲霉及生香酵母在二锅头白酒生产中的应用

通过对红曲霉和生香酵母的初筛、复筛,确定了生产应用菌株。该系列菌株应用于二锅头原酒生产,可有效提高原酒质量。     

Effects of 3-Hydrogenkwadaphnin on intracellular purine nucleotide contents and their link to K562 cell death

Our previous studies have classified 3-Hydrogenkwadaphnin (3-HK), isolated from Dendrostellera lessertii (Thymelaeaceae), as a strong anti-proliferative agent that induces apoptosis among the treated leukemia cells mainly through IMP dehydrogenase inhibition. To disclose this point, we measured the intracellular ATP and GTP levels among K562 cells exposed to a single dose of 3-HK (7, 12 and 25 nM). The HPLC analyses of the 3-HK-treated cell lysates indicated a dose-dependent reduction in both GTP and ATP levels. The reduction of purine nucleotide levels was also associated with decreased activity of adenylosuccinate synthetase (AdSS) and enhanced level of cell death through apoptosis. However, the inhibitory effect of 3-HK was reversed by exogenous addition of guanosine with respect to GTP and partially with respect to ATP level. These data suggest that 3-HK targets a delicate regulatory system which governs the life/death fate of the cells partially through modulation of the GTP/ATP pool sizes.     

郭海藻和夏琳人物形象之互文性解析

将《蜗居》中的郭海藻和《奋斗》中的夏琳相比较,这两个人物形象在社会背景、人生价值观以及婚姻观这些层面上具有互文性。夏琳人物形象不仅仅是对郭海藻人物形象的简单模仿,而是更高层次上的颠覆和重塑,体现了当代新女性主义的特征。     

藏药大三果抗氧化活性研究

研究了藏药大三果药剂三果汤含片及配伍三种成分毛诃子、诃子、余甘子清除超氧阴离子自由基（·O2-）、羟基自由基（·OH）的能力.结果表明,三者清除·O2-能力大小依次为：毛诃子＞余甘子＞诃子,清除·OH能力大小依次为：毛诃子＞诃子＞余甘子.此外,分析毛诃子、诃子、余甘子及三果汤含片中活性成分没食子酸的含量发现,三果汤含片的抗氧化性能主要与三种配伍成分中没食子酸的含量有一定关系.     

传统与科技接轨——历史建筑数字化保护及改造再利用研究

通过对四川省乐山市沙湾区郭沫若故居历史地段与传统民居建筑的系统调查,采用三维激光扫描技术来探究数字化的保护过程及其特点,并强调以原真性、可识别性、科学性、可操作性、可持续性五大思想为指导,利用现代建筑设计理论、方法及三维激光扫描数字技术,针对郭沫若故居及其周边历史地段进行数字化保护和改造再利用研究。     

质疑郭沫若女权主义思想

探讨了五四诗坛巨星郭沫若先生的女权主义思想问题。学者大多认同郭沫若先生是女性的崇拜与赞美者，褒扬他的女权主义思想。但从郭沫若先生的几重婚姻情感纠葛来看，他的女权主义思想在现实中是矛盾的：他对于女性虽有崇拜与赞美，但实则仍不免是旧封建礼教与男性“菲勒斯主义”下的女性贬抑与蔑视者。