舌像颜色校正算法对比研究

The color of tongue coating is an important feature in tongue diagnosis of traditional Chinese Medicine. In order to solve the problem of color distortion in image acquisition of TCM tongue image in natural environment, when shooting the tongue image, the standard color card is placed beside the tongue to shoot together, and the polynomial regression algorithm is used to correct the color of the image. Experimental results show that the proposed method is more accurate than perfect reflection algorithm, gray world algorithm, color deviation detection and color correction algorithm.     

Towards elucidating the connection between epithelial–mesenchymal transitions and stemness

Epithelial cells undergoing epithelial-to-mesenchymal transitions have often been shown to behave as cancer stem cells, but the precise molecular connection remains elusive. At the genetic level, stemness is governed by LIN28/let-7 double inhibition switch, whereas EMT/MET is controlled by miR-200/ZEB double inhibition circuit and LIN28 is inhibited by miR-200, coupling the two modules. Here, using a specially devised theoretical framework to investigate the dynamics of the LIN28/let-7 system, we show that it can operate as a three-way switch (between low, high and intermediate LIN28 levels termed the D, U and hybrid D/U states) similar to the three-way operation of the miR-200/ZEB circuit that allows for the existence of a hybrid epithelial/mesenchymal (E/M) phenotype. We find significant correspondence between the existence of the three states of the two circuits: E–D, M–U and E/M–D/U. Incorporating the activation of OCT4 by LIN28, we find that the hybrid E/M phenotype has high likelihood (when compared with either the E or M states) to gain stemness. Combining the LIN28/let-7 regulation by NF-κB and c-MYC, we find that NF-κB, but not c-MYC, elevates the likelihood of E/M phenotype to gain stemness. Our results are consistent with emerging concept that partial EMT can lead to stemness.     

无线Internet发展中的关键技术探讨

从物理层、数据键路层和网络层入手,对无线移动Internet技术现状作了简要的介绍并分析了其所存在的问题,重点对在今后发展中可能会采用的关键技术进行了研究与探讨。     

杭州古树名木保护略论

在整理杭州市区古树名木历次调查资料的档案以及相关文献的基础上，进行数量，树龄的分类统计，科属种的增减，以及生存环境及生长情况等4个方面的分析研究，提出了保护和管理古树名木的一些合理化建议。     

基于CAN/LIN总线的车灯控制系统的设计

介绍了CAN/LIN总线技术在车灯控制系统设计中的应用,做出了MC33889和MC33880芯片的简化应用图,完成了CAN/LIN网关设计的结构,给出了基于CAN/LIN总线硬件设计的原理,最后给出了软件设计思路.     

基于LIN总线的汽车照明系统软硬件开发

LIN总线作为汽车电子中常见的一种总线协议,因其通用性广、成本低廉受到众厂商的青睐.为了将LIN总线应用到汽车照明系统上,对LIN报文帧进行了详细的研究,对各个字节的内容进行详细的解释.随后在通用串口的基础上,设计了一套基于LIN总线的汽车照明系统,并给出了主从节点不同的硬件电路图和软件流程图.最终完成了整个照明系统的开发要求.     

一种新型的汽车A类总线LIN

介绍LIN总线的特点、应用领域,对LIN最新的版本LIN2·0规范各部分的关键技术进行了较为详细的阐述,并对LIN和CAN两种总线的主要性能进行了比较。     

LIN总线通信展示板的实现

介绍了LIN总线及其通信特点，分析了LIN总线通信的帧结构和通信协议；针对LIN总线在汽车低速通信中的模拟应用，设计了LIN总线硬件电路和LIN展示板，详细阐述了其功能和软件流程；展望了LIN总线的发展前景。     

Chromenopyrazole−Peptide Conjugates as Small-Molecule Based Inhibitors Disrupting the Protein−RNA Interaction of LIN28-let-7

Targeting the protein−RNA interaction of LIN28 and let-7 is a promising strategy for the development of novel anticancer therapeutics. However, a limited number of small-molecule inhibitors disrupting the LIN28-let-7 interaction with potent efficacy are available. Herein, we developed a novel LIN28-inhibiting strategy by targeting selective hotspot amino acids at the LIN28-let-7 binding interface with small-molecule-based bifunctional conjugates. Starting from reported small-molecule LIN28 inhibitors, we identified a feasible linker-attachment position after performing a structure-activity relationship exploration based on the LIN28-targeting chromenopyrazoles. In parallel, a virtual alanine scan identified hotspot residues at the protein−RNA binding interface, based on which we designed a set of peptides to enhance the interaction with the identified hotspot residues. Conjugation of the tailor-designed peptides with linker-attached chromenopyrazoles yielded a series of bifunctional small-molecule-peptide conjugates, represented by compound 83 (PH-223), as a new LIN28-targeting chemical modality. Our result demonstrated an unexplored rational design approach using bifunctional conjugates to target protein−RNA interactions.     

基于LIN总线的车灯控制的故障诊断系统

为了实现汽车控制系统中电子单元之间的实时通信,提出了一种基于MOTOROLA芯片的LIN总线车灯控制的故障诊断系统的设计方案.详细介绍了LIN总线在车灯模块中的应用,对车灯控制中可能产生的故障进行了分析,并给出了硬件电路和软件设计思想.试验表明,该系统不仅可以通过LIN总线的应用,准确、可靠、实时地对数据进行传输,实现对车灯的控制,而且可以对故障进行准确诊断.试验证明了所提方案的可行性.