A liquefied energy chain for transport and utilization of natural gas for power production with CO2 capture and storage – Part 2: The offshore and the onshore processes

A novel energy and cost effective transport chain for stranded natural gas utilized for power production with CO₂ capture and storage is developed. It includes an offshore section, a combined gas carrier, and an integrated receiving terminal. In the offshore process, natural gas (NG) is liquefied to LNG by liquid carbon dioxide (LCO₂) and liquid inert nitrogen (LIN), which are used as cold carriers. The offshore process is self-supported with power, hot and cold utilities and can operate with little rotating equipment and without flammable refrigerants. In the onshore process, the cryogenic exergy in LNG is used to cool and liquefy the cold carriers, which reduces the power requirement to 319 kWh/tonne LNG. Pinch and exergy analyses are used to determine thermodynamically optimized offshore and onshore processes with exergy efficiencies of 87% and 71%, respectively. There are very low emissions from the processes. The estimated specific costs for the offshore and onshore process are 8.0 and 14.6 EUR per tonne LNG, respectively, excluding energy costs. With an electricity price of 100 EUR per MWh, the specific cost of energy in the onshore process is 31.9 EUR per tonne LNG.     

基于LIN总线的车灯控制的故障诊断系统

为了实现汽车控制系统中电子单元之间的实时通信,提出了一种基于MOTOROLA芯片的LIN总线车灯控制的故障诊断系统的设计方案.详细介绍了LIN总线在车灯模块中的应用,对车灯控制中可能产生的故障进行了分析,并给出了硬件电路和软件设计思想.试验表明,该系统不仅可以通过LIN总线的应用,准确、可靠、实时地对数据进行传输,实现对车灯的控制,而且可以对故障进行准确诊断.试验证明了所提方案的可行性.     

基于CAN/LIN总线的车灯控制器设计与实现

提出一种基于CAN/LIN总线的车灯控制器设计方案.详细介绍总线在车灯控制器中的应用及车灯的驱动控制模块,对车灯控制中可能产生的故障进行分析,并给出硬件实现和软件流程.实验证明该控制器不仅具有各灯光负载的直接驱动能力,而且可实现对各车灯的故障诊断及故障信息的总线发送功能.     

LIN28 Family in Testis: Control of Cell Renewal,Maturation, Fertility and Aging

Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.     

基于CAN的车身控制系统的设计与实现

为了满足现代汽车上越来越多的电子控制单元对彼此数据要求共享的发展趋势，现代汽车的车身控制系统开始采用基于CAN总线协议的网络控制系统.首先介绍了CAN总线技术，并从成本、性能方面重点阐述了其与LIN总线相结合的必要性和可行性.在此基础上，对车载分布式控制网络进行了结构分析和设计，最后在硬件、软件两方面，实现了基于CAN/LIN总线和SAE-J1939协议的车载分布式控制网络.该控制网络实现了整车电器连接的总线化，提高了系统的安全性、可维护性、可扩展性，满足了现代汽车的控制和管理要求.     

基于CAN/LIN总线的车灯控制系统的设计

介绍了CAN/LIN总线技术在车灯控制系统设计中的应用,做出了MC33889和MC33880芯片的简化应用图,完成了CAN/LIN网关设计的结构,给出了基于CAN/LIN总线硬件设计的原理,最后给出了软件设计思路.     

LIN应用层协议开发

LIN是一种低成蕾、高效率的汽车网络协议，作为CAN总线的辅助网络被大量使用。本文在分析LIN总线通讯模式的基础上，根据CAN、LIN网络的接口特点，以长安公司SC6350车型为对象，设计了一个简单、通用、高效的可用于CAN／LIN混合网的LIN应用层协议．给出了协议实现的框架结构，并通过实例说明了协议的实现过程。     

基于CAN/LIN总线的即插即用式监控系统

针对目前总线式监控系统在应用过程中存在的适应性差和扩展不方便的问题,提出了一种基于CAN/LIN总线的即插即用式监控系统。系统主要由监控PC机、节点设备和独立设备三部分组成,监控PC机利用数据库的枚举程序分配设备地址,设备中的单片机借助EEPROM存储所分配到的地址,采用CAN/LIN总线通讯技术,完成了设备的即插即用。利用LabVIEW开发了基于CAN/LIN总线的监控系统,使得系统在进行监控的同时能够随时增减设备,提高了系统的自适应性和可扩展性。     

1553B总线简介及其实现

首先概况介绍了1553B总线的特点、通信协议、字格式以及消息格式,并以BU65170为例讲述了协议芯片的结构和总线协议的实现。设计的通信系统包含BC-RT,RT-RT以及广播3种类型的总线消息,数据量大而复杂,硬件采用高速CPU和总线芯片相配合的方式,芯片工作于非零等待模式,软件采用主程序和中断相结合的处理方式,保证了消息实时准确的传输。使用测试仿真卡和测试设备进行测试,系统功能可靠稳定,已成功应用于实际设备中。     

Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-Binding Protein LIN28 and Let-7

Small-molecule inhibitors of the RNA-binding and regulating protein LIN28 have the potential to be developed as chemical probes for biological perturbation and as therapeutic candidates. Reported small molecules disrupting the interaction between LIN28 and let-7 miRNA suffer from moderate to weak inhibitory activity and flat structure-activity relationship, which hindered the development of next-generation LIN28 inhibitors that warrant further evaluations. We report herein the identification of new LIN28 inhibitors utilizing a spirocyclization strategy based on a chromenopyrazole scaffold. Representative compounds 2 – 5 showed potent in vitro inhibitory activity against LIN28-let-7 interaction and single-digit micromolar potency in inhibiting the proliferation of LIN28-expressing JAR cancer cells. The spirocyclic compound 5 incorporated a position that is amenable for functional group appendage and further structural modifications. The binding mode of compound 5 with the LIN28 cold shock domain was rationalized via a molecular docking analysis.