低碳钢显微结构的EBSD表征

近年来,新开发的电子背散射衍射技术将多晶材料的显微组织、微区成分与结晶学数据分析联系起来,能对晶界类型、取向、位向差和结构及其分布进行观察、统计测定和定量分析,从而建立了晶界结构、取向和织构等与多晶材料性能的定量和半定量关系,成为现代材料研究的重要实验技术。笔者结合低碳钢生产中的一些实际问题,扼要介绍了电子背散射衍射技术中的晶体取向图在多晶材料显微结构表征中的应用。     

基于红外检测的变电站设备热状态诊断

提出了一种基于红外检测的变电站设备热状态诊断方案。首先基于变电站设备的红外图像,采用局部方差映射函数和遗传算法阈值提取了变电站设备的热状态数据,以用于对异常区域进行分割。然后构建了红外图像灰度数与变电站设备温度两者之间的关系。最后采用改进的相对温差法达到了对设备热状态进行分类和诊断的目标,并捕获定位了变电站设备的热状态异常区域。实验结果表明,该方法提高了异常热区提取的精度和效率,提升了变电站设备热状态诊断的容错能力,进一步保证了变电站和整个电力系统的运行稳定性。     

Gap Junctional Communication via Connexin43 between Purkinje Fibers and Working Myocytes Explains the Epicardial Activation Pattern in the Postnatal Mouse Left Ventricle

The mammalian ventricular myocardium forms a functional syncytium due to flow of electrical current mediated in part by gap junctions localized within intercalated disks. The connexin (Cx) subunit of gap junctions have direct and indirect roles in conduction of electrical impulse from the cardiac pacemaker via the cardiac conduction system (CCS) to working myocytes. Cx43 is the dominant isoform in these channels. We have studied the distribution of Cx43 junctions between the CCS and working myocytes in a transgenic mouse model, which had the His-Purkinje portion of the CCS labeled with green fluorescence protein. The highest number of such connections was found in a region about one-third of ventricular length above the apex, and it correlated with the peak proportion of Purkinje fibers (PFs) to the ventricular myocardium. At this location, on the septal surface of the left ventricle, the insulated left bundle branch split into the uninsulated network of PFs that continued to the free wall anteriorly and posteriorly. The second peak of PF abundance was present in the ventricular apex. Epicardial activation maps correspondingly placed the site of the first activation in the apical region, while some hearts presented more highly located breakthrough sites. Taken together, these results increase our understanding of the physiological pattern of ventricular activation and its morphological underpinning through detailed CCS anatomy and distribution of its gap junctional coupling to the working myocardium.     

基于XML异构数据库集成中间件的设计与实现

为了解决网络环境中异构数据库数据共享和协作问题,提出了基于XML中间件技术实现异构数据库之间信息交换模型.在此模型中对虚拟法或中介法模型进行改进设计了翻译器、集成器和转换器,分别用于数据获取、合并和格式转换.为了更精确地描述XML文件自身结构信息,实现了从DTD到XML Schema的转换.     

一种高动态范围图像可视化算法*

提出的自适应HDR图像可视化算法中,输入图像被分解为基本层和细节层.该算法将整体明暗效果的显示看做整体问题,对表示亮度的基本层采用基于整体统计信息的直方图调整算法处理;可视细节信息的保持作为局部问题,算法采用自适应细节增强算法处理细节层.通过定义映射图对细节增强后的图像进行最终映射,将两方面结合起来得到最终结果.实验结果表明,该算法能对HDR图像进行较高视觉质量的显示.     

多信息源下本体自动抽取的实现*

以关系型数据库、XML文件、HTML文件、一般文档为信息源,运用不同的方法分别将多信息源映射为概念图,并按照拟定的概念逻辑结构进行统一存储,最后运用抽取算法实现本体的自动抽取.     

弹性半无限空间中矩形孔收缩的复变函数解答

随着城市建设的发展,矩形隧道的应用越来越多,但针对矩形隧道的理论研究却鲜有见闻。针对矩形隧道,建立了半无限空间矩形隧道的弹性理论计算模型,采用最小二乘迭代方法确定共形映射函数的各项系数,并将计算区域映射为复平面上的一个同心圆环;运用Muskhelishvili复变函数方法,将计算区域内的应力函数展开成为Laurant级数的形式,给定了地表零应力边界和矩形孔口径向位移边界,求得了半无限空间矩形隧道在给定位移条件下的应力场和位移场。分析了不同高宽比、不同泊松比、不同埋深对位移场和应力场的影响,总结了矩形隧道位移场和应力场的一般规律。结果表明：高宽比偏小、泊松比偏大、埋深偏小都会使得沉降槽不再是类高斯曲线的形状,这些参数的变化也会在不同程度上影响应力场和位移场的大小和分布。     

AKT Inhibitors: The Road Ahead to Computational Modeling-Guided Discovery

AKT, is a serine/threonine protein kinase comprising three isoforms—namely: AKT1, AKT2 and AKT3, whose inhibitors have been recognized as promising therapeutic targets for various human disorders, especially cancer. In this work, we report a systematic evaluation of multi-target Quantitative Structure-Activity Relationship (mt-QSAR) models to probe AKT’ inhibitory activity, based on different feature selection algorithms and machine learning tools. The best predictive linear and non-linear mt-QSAR models were found by the genetic algorithm-based linear discriminant analysis (GA-LDA) and gradient boosting (Xgboost) techniques, respectively, using a dataset containing 5523 inhibitors of the AKT isoforms assayed under various experimental conditions. The linear model highlighted the key structural attributes responsible for higher inhibitory activity whereas the non-linear model displayed an overall accuracy higher than 90%. Both these predictive models, generated through internal and external validation methods, were then used for screening the Asinex kinase inhibitor library to identify the most potential virtual hits as pan-AKT inhibitors. The virtual hits identified were then filtered by stepwise analyses based on reverse pharmacophore-mapping based prediction. Finally, results of molecular dynamics simulations were used to estimate the theoretical binding affinity of the selected virtual hits towards the three isoforms of enzyme AKT. Our computational findings thus provide important guidelines to facilitate the discovery of novel AKT inhibitors.     

基于运动误差约束的平面定位平台拓扑优化设计

针对传统平面定位平台拓扑优化设计过程中无法预先了解输入输出位移映射矩阵的问题,基于固体各向同性材料惩罚法,采用遗传算法优化得到具有最大运动空间时的平面并联机构雅克比矩阵作为平面定位平台输入输出期望位移映射矩阵,在相同输入条件下,建立以机构实际运动与期望运动间误差最小为目标函数和以机构体积为约束函数的平面定位平台拓扑优化模型并求解。通过3D打印方式得到实验样品,实验与仿真分析表明:采用运动误差约束的平面定位平台拓扑优化设计方法,在一定偏差范围能够得到输入输出位移映射矩阵与给定期望映射矩阵相一致的平面定位平台,表明该方法对平面定位平台设计具备有效性,为其后续研究提供基础。     

无模多点成形中三维曲面工件的展开方法

本文从几何映射的角度出发 ,以面积不变为基本的展开原则 ,提出了适合于板材无模多点成形工艺的自由曲面展开的计算方法———三角形曲面片展开法和约束加权整体展开法 ,并用VC ++编制了相应的计算机程序。文中以鞍形样件和高速列车车头蒙皮的部分工件为例 ,进行了实际验算。