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41.
Malgorzata Młynarczyk Malgorzata Sznitowska Dorota Watrobska-Swietlikowska 《Drug development and industrial pharmacy》2013,39(4):355-362
Antimicrobial efficacy of methyl and propylparaben combination as potential preservatives for submicron emulsions, and the effect of oil and lecithin concentration on the microbial growth were investigated. Parabens were ineffective in standard or doubled concentrations as per pharmacopoeial criteria. Poor growth inhibition and multiplication of reference strains point to protective and growth properties of submicron emulsions. No correlation was observed between oil/lecithin ratio and efficacy of parabens; partitioning of the latter into the oily phase and lipophilic domains could be the reason for such effect. Further studies are necessary to establish a stable and safe composition of such formulations. 相似文献
42.
De La Torre Jessica Elizabeth Fatma Gassara Anne Patricia Kouassi Khaled Belkacemi 《Critical reviews in food science and nutrition》2017,57(6):1078-1088
Spices are parts of plants that due to their properties are used as colorants, preservatives, or medicine. The uses of spices have been known since long time, and the interest in the potential of spices is remarkable due to the chemical compounds contained in spices, such as phenylpropanoids, terpenes, flavonoids, and anthocyanins. Spices, such as cumin (cuminaldehyde), clove (eugenol), and cinnamon (cinnamaldehyde) among others, are known and studied for their antimicrobial and antioxidant properties due to their main chemical compounds. These spices have the potential to be used as preservatives in many foods namely in processed meat to replace chemical preservatives. Main chemical compounds in spices also confer other properties providing a variety of applications to spices, such as insecticidal, medicines, colorants, and natural flavoring. Spices provide beneficial effects, such as antioxidant activity levels that are comparable to regular chemical antioxidants used so they can be used as a natural alternative to synthetic preservatives. In this review, the main characteristics of spices will be described as well as their chemical properties, different applications of these spices, and the advantages and disadvantages of their use. 相似文献
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Microencapsulation of red and white thyme oil in poly(lactic‐co‐glycolic) acid: Assessment of encapsulation efficiency and antimicrobial capacity of the produced microcapsules 下载免费PDF全文
45.
Comparison of antimicrobial activities of polyacrylonitrile fibers modified with quaternary phosphonium salts having different alkyl chain lengths 下载免费PDF全文
A series of polyacrylonitrile fibers (PANF) modified with quaternary phosphonium salts having various alkyl chain lengths (C1, C2, C6, C8, C12) were synthesized and compared for their antimicrobial activities by the improved shake flask method. The as‐prepared fibers were named MTPB‐PANF, ETPB‐PANF, HTPB‐PANF, OTPB‐PANF, and DTPB‐PANF, respectively. The representative microorganisms employed were Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Candida albicans (C. albicans). Results from the current study showed that the alkyl chain length of quaternary phosphonium salts not only affected the synthesis of the fibers, but also impacted their antimicrobial activities. There was a rule that the longer the alkyl chain length, the more easily the quaternary phosphonium salts modify the fibers and the better the antimicrobial activities of the modified fibers. All the modified fibers exhibited good broad‐spectrum antimicrobial activities. Specifically, DTPB‐PANF exhibited an outstandingly high antimicrobial activity, which was nearly unaffected by the environmental pH (3–10). It can kill all the four pathogens in 15 min and had an excellent wash‐resistant property. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43689. 相似文献
46.
Gramicidin A Mutants with Antibiotic Activity against Both Gram‐Positive and Gram‐Negative Bacteria 下载免费PDF全文
Antimicrobial peptides (AMPs) have shown potential as alternatives to traditional antibiotics for fighting infections caused by antibiotic‐resistant bacteria. One promising example of this is gramicidin A (gA). In its wild‐type sequence, gA is active by permeating the plasma membrane of Gram‐positive bacteria. However, gA is toxic to human red blood cells at similar concentrations to those required for it to exert its antimicrobial effects. Installing cationic side chains into gA has been shown to lower its hemolytic activity while maintaining the antimicrobial potency. In this study, we present the synthesis and the antibiotic activity of a new series of gA mutants that display cationic side chains. Specifically, by synthesizing alkylated lysine derivatives through reductive amination, we were able to create a broad selection of structures with varied activities towards Staphylococcus aureus and methicillin‐resistant S. aureus (MRSA). Importantly, some of the new mutants were observed to have an unprecedented activity towards important Gram‐negative pathogens, including Escherichia coli, Klebsiella pneumoniae and Psuedomonas aeruginosa. 相似文献
47.
Studying of cellular interaction of hairpin‐like peptide EcAMP1 from barnyard grass (Echinochloa crusgalli L.) seeds with plant pathogenic fungus Fusarium solani using microscopy techniques 下载免费PDF全文
48.
Beya Haouas Taieb Saied Hanen Ayari Youssef Arfaoui Mohamed Lamine Benkhoud Khaled Boujlel 《Journal of Sulfur Chemistry》2016,37(4):391-400
Electrogenerated cyanomethylanions obtained by reduction of dry acetonitrile at a steel grid cathode were used to promote the addition of ethyl bromoacetate to thiourea derivatives. The reaction yields the corresponding 2-imino-1,3-thiazolidin-4-one. The reaction pathway was discussed based on the kinetic and thermodynamic data obtained by computational methods. In addition, the biological activity of these new compounds was also investigated. 相似文献
49.
Nadjet Rezki Salsabeel A. Al-Sodies Mohamed R. Aouad Sanaa Bardaweel Mouslim Messali El Sayed H. El Ashry 《International journal of molecular sciences》2016,17(5)
The present work reports an efficient synthesis of fluorinated pyridinium salts-based hydrazones under both conventional and eco-friendly ultrasound procedures. The synthetic approach first involves the preparation of halogenated pyridinium salts through the condensation of isonicotinic acid hydrazide (1) with p-fluorobenzaldehyde (2) followed by the nucleophilic alkylation of the resulting N-(4-fluorobenzylidene)isonicotinohydrazide (3) with a different alkyl iodide. The iodide counteranion of 5–10 was subjected to an anion exchange metathesis reaction in the presence of an excess of the appropriate metal salts to afford a new series of fluorinated pyridinium salts tethering a hydrazone linkage 11–40. Ultrasound irradiation led to higher yields in considerably less time than the conventional methods. The newly synthesized ILs were well-characterized with FT-IR, 1H NMR, 13C NMR, 11B, 19F, 31P and mass spectral analyses. The ILs were also screened for their antimicrobial and antitumor activities. Within the series, the salts tethering fluorinated counter anions 11–13, 21–23, 31–33 and 36–38 were found to be more potent against all bacterial and fungal strains at MIC 4–8 µg/mL. The in vitro antiproliferative activity was also investigated against four tumor cell lines (human ductal breast epithelial tumor T47D, human breast adenocarcinoma MCF-7, human epithelial carcinoma HeLa and human epithelial colorectal adenocarcinoma Caco-2) using the MTT assay, which revealed that promising antitumor activity was exhibited by compounds 5, 12 and 14. 相似文献
50.