硫酸软骨素的药理作用及应用研究进展

综述近年国内外有关硫酸软骨素的研究,主要涉及其药理作用、临床和生物医学中的应用等。     

Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy

The biomedical applications of carbon nanotubes (CNTs) have attracted deep interest in recent years. Antitumor immunotherapy has the potential to improve the prognosis of cancer treatment but the efficacy of current immunotherapy generally needs further improvement. Multi-walled CNTs conjugated to tumor lysate protein are investigated as to whether they would enhance the efficacy of an immunotherapy employing a tumor-cell vaccine in a mouse model bearing the H22 liver cancer. The tumor cure rate is found to be markedly improved by CNTs conjugated to tumor lysate protein. The cellular antitumor immune reaction is also enhanced. Moreover, the observed antitumor immune response is relatively specific against the tumor intended for treatment. These findings suggest that CNTs may have a prospective role in the development of new antitumor immunotherapies.     

生物医学实验室全面建设中需要解决的医学计量检测课题

通过学习、研讨相关(ISO、GB)标准并结合实验室认可等实际情况,提出了在生物医学实验室"安全"、"质量"、"能力"的全面建设中,需要解决的医学计量界检测保障课题。急需工业计量界、检测界给予关注和支持。     

导电水凝胶基摩擦纳米发电机的性能优化与应用研究进展

近年来,摩擦纳米发电机（TENG）作为新兴的供能装备备受关注,水凝胶作为一种集透明、柔性、导电和自愈合等性能于一体的多功能材料,成为制备TENG的热门材料,本文首先对TENG的基本原理进行了介绍,对水凝胶基TENG在输出性能、环境适应性能及自愈合性能等热点研究的最新报道进行了系统的归纳与总结,详述了其在自供电传感器、能量采集设备、生物医疗及人机交互等方面的应用,总结了当前水凝胶基TENG面临的主要挑战,并对其潜在的发展方向进行了展望。     

木质素基水凝胶的应用研究进展

木质素是世界上含量仅次于纤维素的生物聚合物,也是地球上可供人类利用的最丰富的芳烃资源。木质素丰富的官能团也为其高值利用提供了可能。本文从木质素基水凝胶最新的发展动态展开,综述当前木质素基水凝胶的制备方法、应用领域及发展状况,具体介绍了木质素基水凝胶在生物医药、传感应变及吸附等较为热门领域的最新研究成果。     

可调谐超表面的生物分子检测研究进展

超表面作为一种超薄微纳器件具有优良的性能,利用超表面检测生物分子具有越来越广泛的前景。本文调研了可调谐超表面检测生物分子的研究进展,并分别从太赫兹波段、中红外波段、光波段阐述当前的研究成果。本文重点介绍了当前超表面利用外加电压、改变环境温度等实现可调谐的方法,并对超表面检测不同生物分子的性能进行了总结分析,最后给出了可调谐超表面在生物分子检测方面未来发展的机遇与挑战。     

葡聚糖磁性微球在生物医学领域的应用

葡聚糖磁性微球作为一种新型功能材料,在生物医学、细胞学和生物工程学等领域有着广泛的应用前景.着重介绍了葡聚糖磁性微球在固定化酶、靶向药物、细胞分离与免疫分析、临床诊断和治疗等领域的应用,并展望了今后的研究方向.     

基于扫描探针显微镜的近场超空间分辨指纹光谱技术研究现状

基于扫描探针显微镜的近场超空间分辨指纹光谱技术在分子识别及组分鉴别方面具有极大的应用前景.扫描探针显微技术与不同的光谱联合使用,发展出了不同的具有纳米级分辨的指纹光谱技术,其中包括针尖增强拉曼散射光谱技术、纳米级分辨率的傅里叶变换红外光谱技术及散射式的扫描近场太赫兹光谱技术.这三种散射式的扫描近场光学显微技术在实现方式上有所不同,在近场指纹识别方面可以相互补充.该综述主要对三种近场超空间分辨指纹光谱技术的特点进行了深入地分析和比较,并且对这三种技术的研究现状及应用进行了总结.     

Biomedical Applications of DNA‐Based Hydrogels

Nucleic acids are gaining significant attention as versatile building blocks for the next generation of soft materials. Due to significant advances in the chemical synthesis and biotechnological production, DNA becomes more widely available enabling its usage as bulk material in various applications. This has prompted researchers to actively explore the unique features offered by DNA‐containing materials like hydrogels. In this review article, recent developments in the field of hydrogels that feature DNA as a component either in the construction of the material or as functional unit within the construct and their biomedical applications are discussed in detail. First, different synthetic approaches for obtaining DNA hydrogels are summarized, which allows classification of DNA materials according to their structure. Then, new concepts, properties, and applications are highlighted such as DNA‐based biosensor devices, drug delivery platforms, and cell scaffolds. With the 2018 Nobel Prize in Physiology or Medicine being awarded to cancer immunotherapy underscoring the importance of this therapy, DNA hydrogel systems designed to modulate the immune system are introduced. This review aims to give the reader a timely overview of the most important and recent developments in this emerging class of therapeutically useful materials of DNA‐based hydrogels.     

卟啉-多肽超分子组装体系的研究进展

近年来,卟啉-多肽的超分子组装体系的研究受到了国内外学者的广泛关注,已成为超分子化学、生物材料科学研究的前沿领域之一。卟啉-多肽超分子组装体系因具有结构和功能多样化以及良好的生物相容性等优点,在生物传感、药物治疗、分子识别和光电器件等方面展示出巨大的应用潜力。文章综述了卟啉和多肽超分子构筑模块的分子结构设计、组装体的形貌调控、组装体应用3个方面的主要研究进展,介绍了卟啉与多肽分子之间的主要非共价作用方式,包括分子间静电相互作用、氢键、配位键、亲水/疏水性等,分析了该领域当前研究的焦点及亟需解决的问题。