Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study

Severe periodontitis is prevalent in Down syndrome (DS). This study aimed to identify genetic variations associated with periodontitis in individuals with DS. The study group was distributed into DS patients with periodontitis (n = 50) and DS patients with healthy periodontium (n = 36). All samples were genotyped with the “Axiom Spanish Biobank” array, which contains 757,836 markers. An association analysis at the individual marker level using logistic regression, as well as at the gene level applying the sequence kernel association test (SKAT) was performed. The most significant genes were included in a pathway analysis using the free DAVID software. C12orf74 (rs4315121, p = 9.85 × 10⁻⁵, OR = 8.84), LOC101930064 (rs4814890, p = 9.61 × 10⁻⁵, OR = 0.13), KBTBD12 (rs1549874, p = 8.27 × 10⁻⁵, OR = 0.08), PIWIL1 (rs11060842, p = 7.82 × 10⁻⁵, OR = 9.05) and C16orf82 (rs62030877, p = 8.92 × 10⁻⁵, OR = 0.14) showed a higher probability in the individual analysis. The analysis at the gene level highlighted PIWIL, MIR9-2, LHCGR, TPR and BCR. At the signaling pathway level, PI3K-Akt, long-term depression and FoxO achieved nominal significance (p = 1.3 × 10⁻², p = 5.1 × 10⁻³, p = 1.2 × 10⁻², respectively). In summary, various metabolic pathways are involved in the pathogenesis of periodontitis in DS, including PI3K-Akt, which regulates cell proliferation and inflammatory response.     

离散型制造企业进销存信息管理系统的设计与实现

针对某离散制造企业的业务流程，采用C／S（Client／Server）结构模式，使用VB6．0作为前台开发工具，SQL Server2000做后台数据库，开发了企业进销存管理系统。该系统以企业管理的计划和控制职能为核心，提供了采购、库管、销售、计划等实用而丰富的管理功能，可以对企业的经营管理活动分析、预测。文章介绍了系统的建模、设计和实现过程。     

炼厂硫腐蚀的典型案例分析及解决措施

通过硫在不同温度与环境下对金属材料腐蚀的典型案例分析，简述其腐蚀机理与解决,工对今后炼厂高硫油加工提出进一步建议。     

船舶钢板激光弯曲成形的实验研究

在对船舶钢板激光弯曲成形过程进行实验研究中，采用CO2激光器研究了激光功率、扫描速度、扫描次数以及钢板厚度对船舶钢板激光弯曲成形的影响规律。实验中实时测量了船舶钢板激光弯曲成形过程钢板弯曲角度和温度的变化。结果表明：钢板弯曲角度随激光功率的增加而增加，随激光束扫描速度的增加而减小，而且随着钢板厚度的增加，弯曲角度减小；激光工艺参数和钢板厚度都对钢板激光多次扫描成形产生影响，钢板的弯曲角度随着激光扫描次数的增加而增加。对于较薄的船舶钢板，钢板弯曲角度随扫描次数增加近似呈线性增加，而较厚的钢板，随扫描次数的增加，钢板弯曲角度的增加逐渐减小。     

高温烟气过滤筒制作工艺研究

本文对除尘净化设备常用的过滤材料进行了综述对比 ,提出了一种新型的过滤材料 ,该过滤材料可以在高温下直接使用 ,有利于简化除尘净化设备。同时对用这一新型的过滤材料制作过滤筒的工艺进行了初步探讨和研究。     

齿轮精锻的数值模拟与实验研究

本文对空心直齿圆柱齿轮的精锻成形过程进行三维刚塑性有限元模拟和实验研究。通过有限元数值模拟和实验研究 ,得出了直齿圆柱齿轮精锻过程的金属流动规律和变形力学特征 ,揭示了直齿圆柱齿轮精锻过程的变形机理 ,数值模拟结果与实验结果吻合较好     

Determination of tetrachloroethylene—Results of a collaborative study and the standardized method

The development, by collaborative study, of a standardized method for the determination of tetrachloroethylene in olive oils is described. The results of the study, which was carried out in 1989 under the direction of the International Olive Oil Council (IOOC), are presented and show that tetrachloroethylene can be readily determined, to an acceptable degree of precision, by gas-liquid chromatography with electron capture detection. A limited number of results obtained for the determination of trichloroethylene and chloroform by the same method indicate that a similar precision could be obtained with the method when determining these solvents also.     

石油勘探开发行业可持续发展战略研究

从可持续发展的基本内涵出发，初步研究了石油勘探开发行业可持续发展的主要特征和指导原则，并提出了石油勘探开发行业可持续发展的若干主要对策。将可持续发展思想和战略逐渐融进石油工业业务活动中去，对我国石油工业的持续稳定发展具有十分重要的意义。     

Mechanistic Insight in the Ethane Dehydrogenation Reaction over Cr/Al2O3 Catalysts

A Cr/Al₂O₃ alkane dehydrogenation catalyst exhibits a maximum in ethylene yield during an ethane dehydrogenation cycle. Isotopic labelling experiments with monolabelled ¹³C-ethane and deuterium were used to elucidate whether the initial activity increase could be due to formation of an active, larger hydrocarbon intermediate on the surface. The results strongly indicate that this is not the case, and instead point to a traditional reaction cycle involving adsorption of ethane to form an ethyl species, followed by desorption of ethene and hydrogen. Transient kinetic data suggest that ethane adsorption is the rate-determining step of reaction.     

Investigating dependencies in software requirements for change propagation analysis

ContextThe dependencies between individual requirements have an important influence on software engineering activities e.g., project planning, architecture design, and change impact analysis. Although dozens of requirement dependency types were suggested in the literature from different points of interest, there still lacks an evaluation of the applicability of these dependency types in requirements engineering.ObjectiveUnderstanding the effect of these requirement dependencies to software engineering activities is useful but not trivial. In this study, we aimed to first investigate whether the existing dependency types are useful in practise, in particular for change propagation analysis, and then suggest improvements for dependency classification and definition.MethodWe conducted a case study that evaluated the usefulness and applicability of two well-known generic dependency models covering 25 dependency types. The case study was conducted in a real-world industry project with three participants who offered different perspectives.ResultsOur initial evaluation found that there exist a number of overlapping and/or ambiguous dependency types among the current models; five dependency types are particularly useful in change propagation analysis; and practitioners with different backgrounds possess various viewpoints on change propagation. To improve the state-of-the-art, a new dependency model is proposed to tackle the problems identified from the case study and the related literature. The new model classifies dependencies into intrinsic and additional dependencies on the top level, and suggests nine dependency types with precise definitions as its initial set.ConclusionsOur case study provides insights into requirement dependencies and their effects on change propagation analysis for both research and practise. The resulting new dependency model needs further evaluation and improvement.