Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated to atherosclerosis. Currently, revascularization strategies (bypass grafting, angioplasty) remain the first option for CLI patients, although less than 45% of them are eligible for surgical intervention mainly due to associated comorbidities. Moreover, patients usually require amputation in the short-term. Angiogenic cell therapy has arisen as a promising alternative for these “no-option” patients, with many studies demonstrating the potential of stem cells to enhance revascularization by promoting vessel formation and blood flow recovery in ischemic tissues. Herein, we provide an overview of studies focused on the use of angiogenic cell therapies in CLI in the last years, from approaches testing different cell types in animal/pre-clinical models of CLI, to the clinical trials currently under evaluation. Furthermore, recent alternatives related to stem cell therapies such as the use of secretomes, exosomes, or even microRNA, will be also described.     

Drag reduction of aqueous suspensions of fine solid matter in pipe flows

It is well known that drag reduction properties of polymer solutions in pipe flows are classified into two categories, based on the relationship between the friction factor and the Reynolds number. The degree of drag reduction either increases with an increase in the Reynolds number or is independent of the Reynolds number. In the latter case, the drag reduction behavior is referred to as type B behavior. In this study, the pressure losses of aqueous suspensions of biofibers and graphene oxide flat particles in pipe flows were measured to clarify the effect of the shape of suspended fine solid matter on the friction factor. The experimental results demonstrated that the behavior of the friction factor corresponded with the type B behavior of drag reduction. The mean velocity profile in the range of the turbulent flow was also estimated from the friction factor data.     

超音速热喷涂316L合金涂层在实际炼油环境中的冲蚀行为

利用超音速热喷涂技术在碳钢基体上制备出了316L合金涂层，研究了该涂层在实际炼油环境中的冲蚀行为。结果表明：超音速热喷涂316L合金涂层在实际炼油环境中具有非常好的抗冲蚀性能，长期现场挂片后涂层仍保持完整，仅表面有轻微的冲蚀痕迹，涂层表面形成的保护性氧化膜、涂层金属自身良好的耐蚀性以及涂层较高的硬度是其具有优异抗冲蚀性能的主要原因。     

高频超声波在氧化皮中传播性能标定

对高频超声小在12Cr2MoWVTiB(G102钢）和12Cr1MoV钢钢管运行所产生氧化皮中的传播速度进行了定量标定，并对标定误差进行了统计计算，结果表明，12Cr1MoV钢氧化皮测厚标定点最大偶然误差值为0．050mm,G102钢为0．030mm，并指明了误差来源。     

超声波检测混凝土结构抗冻性的方法研究

依据固体结构动弹模与表面波速度的关系，采用超声波检测混凝土冻融试件的动弹模，并与共振法测出的动弹模进行对比，总结出其内在相关规律，建立起预报混凝土动弹模的回归主程，由测得的波速计算出相应的动弹模，再利用动弹模之比评估出混凝土结构的抗冻性。初步试验和研究表明，此方法研究思路切实可行，符合混凝土冻融特性的基本变化规律，能够实现从度件测试向结构检测的发展，可供混凝土耐久性检测工程参考。     

高速电弧喷涂镍铝打底层结构与性能研究

高速电弧喷涂技术是近年来发展起来的新型热喷涂技术，该技术具有优势，高效，低成本等特点，本文实验研究了高速电弧喷涂镍铝打底涂层的组织结构和力学性能，涂层的界面结合强度大于40MPa，显微硬度平均值为210HV，表面粗糙度表征参数Ra值为13．11um，涂层孔隙率为2．26％，涂层主要由镍铝合金和镍，铝氧化物组成，高速电弧喷涂镍铝涂层结合强度高，涂层组织致密，是优良的打底涂层。     

Response surface regression analysis on FeCrBSi particle in-flight properties by plasma spray

This work discusses the interactive effects between every two of argon flow rate, voltage, and spray distance on in-flight particles by plasma spray and constructs models that can be used in predicting and analyzing average velocity and temperature. Results of the response surface methodology show that the interactive effects between voltage and spray distance on particle inflight properties are significant. For a given argon flow rate, particle velocity and temperature response surface are obviously bending, and a saddle point exists. With an increase in spray distance, the interactive effects between voltage and argon flow rate on particle in-flight properties appear gradually and then weaken. With an increase in voltage, the interactive effects between spray distance and argon flow rate on particle in-flight properties change from appearing to strengthening and then to weakening.     

风切变对风力机尾流湍流特征影响的研究

采用LES方法,对自行开发设计的100 W小型水平轴风力机在有、无风切变两种入流情况下的尾流特征进行了模拟计算,计算中提取了流场稳定后的x、y、z三个方向的瞬间速度、压力等参数的600个数据样本,计算得到了尾流内轴向速度和湍流强度的方均根值,分析了有、无风切变两种入流情况下风力机尾流内的时间平均轴向速度、湍流强度及涡结构等流动特征。结果表明:无风切变入流情况下,尾流内的叶尖涡、中心涡及轴向速度都呈现对称性;而风切变入流情况下,尾流内叶尖涡螺旋轨迹上面部分的螺距明显大于下面部分的螺距,呈现出了非对称性,而中心涡和轴向速度也都呈现出一定的非对称性,且风切变入流情况下尾流内的涡传播距离更远;在y/d6的近尾流区域内,无论入流是否存在风切变,风力机尾流膨胀现象都不很明显;在相同入流湍流强度条件下,有、无风切变入流情况下尾流内湍流强度的变化规律相似,入流风切变对尾流内湍流强度的影响较小。     

工业汽轮机阀杆超音速火焰喷涂的研究

采用超音速火焰喷涂球形烧结态Cr3C2-25%NiCr复合粉末制备高温耐磨损涂层,分析了涂层的显微组织结构,测试了涂层的结合强度、硬度和耐磨性能,结果表明：涂层中以Cr3C2为主的颗粒增强相弥散分布在NiCr固溶体中,涂层的显微硬度比基体(2Cr12MoV)提高了3倍多,摩擦磨损性能也有明显提高。     

柔性气动连续体机器人关节结构设计与运动学分析

基于气动人工肌肉和缆绳组合驱动,提出了一种三自由柔性气动连续体机器人关节,该关节具有结构紧凑、柔顺性高、控制简单等特点。通过分析该机器人关节结构特性,采用修正的D-H法,建立了其正反解运动学模型,求解了其位置运动学解和速度运动学解,通过仿真验证了关节结构的合理性和运动学方程的正确性。