基于CRITIC权的减法集对势法在佛子岭水库汛期分期中的应用

深入了解集对分析在水库汛期分期应用,选取旬中暴雨日总数、旬多年平均雨量、旬中最大3天雨量、旬多年平均来水量、旬中年最大洪峰出现次数等5个指标,采用CRITIC赋权和模糊集对分析方法,构建了基于CRITIC权的减 法集对势汛期分期方法。以佛子岭水库为例,将佛子岭水库汛期划分为前汛期、主汛期、伏旱期和后汛期四个分期,最后与减法集对势法进行了对比分析。分析结果表明：基于CRITIC权减法集对势汛期分期法考虑了不同水文气象因素对汛期分期影响程度相对大小,汛期分期成果合理,为水库调度管理工作提供了参考依据。     

油田采出水Zeta电位和中值粒径对絮凝效果条件研究

该研究依据动态电泳光散射理论进行Zeta电位测定,利用多个激光源的光束投射测定中值粒径,采用絮凝沉降测定胶体颗粒的絮凝体积及沉降速度.着重考察不同采出水添加剂、聚醚类破乳剂、杀菌剂1227、阻垢剂EDTMP、咪唑啉类缓蚀剂与聚合氯化铝(PAC)复配对颗粒聚集Zeta电位、中值粒径、絮凝体积、沉降速度与颗粒聚集之间的关系...     

初始应力损伤对再生混凝土硫酸盐腐蚀的影响

开展了不同骨料取代率(30％、65％和100％)以及不同初始应力水平(0.2、0.4、0.6倍抗压强度)对于再生混凝土抗腐蚀性能影响的试验研究.结果表明,当再生骨料取代率逐级增高时,再生混凝土的腐蚀深度、质量损失率均增加,力学性能指标(抗压强度和动弹性模量)逐渐下降.初始应力损伤对混凝土的影响可以区分为两种,第一,其对...     

Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells

Insulin-like growth factor 1 (IGF-1) not only regulates neuronal function and development but also is neuroprotective in the setting of acute ischemic stroke. G-protein-coupled receptor 17 (GPR17) expression in brain tissue serves as an indicator of brain damage. As whether IGF-1 regulates GPR17 expression remains unknown, the aim of this study is to investigate how IGF-1 regulates GPR17 expression in vitro. Human neuroblastoma SK-N-SH cells were used. Lentivirus-mediated short hairpin RNA (shRNA) was constructed to mediate the silencing of FoxO1, while adenoviral vectors were used for its overexpression. Verification of the relevant signaling cascade was performed using a FoxO1 inhibitor (AS1842856), a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002), and a GPR17 antagonist (cangrelor). Cell proliferation was analyzed using EdU staining; immunofluorescence staining was used to detect the expression and subcellular localization of FoxO1. Chromatin immunoprecipitation was used to analyze the binding of FoxO1 to the GPR17 promoter in SK-N-SH cells. The expression of FoxO1, GPR17, and protein kinase B (also known as Akt) mRNA and protein as well as the levels of FoxO1 and Akt phosphorylation were investigated in this study. IGF-1 was found to downregulate FoxO1 and GPR17 expression in SK-N-SH cells while promoting cell viability and proliferation. Inhibition of FoxO1 and antagonism of GPR17 were found to play a role similar to that of IGF-1. Silencing of FoxO1 by lentivirus-mediated shRNA resulted in the downregulation of FoxO1 and GPR17 expression. The overexpression of FoxO1 via adenoviral vectors resulted in the upregulation of FoxO1 and GPR17 expression. Blocking of PI3K signaling by LY294002 inhibited the effect of IGF-1 on GPR17 suppression. Results from chromatin immunoprecipitation revealed that IGF-1 promotes FoxO1 nuclear export and reduces FoxO1 binding to the GPR17 promoter in SK-N-SH cells. Here, we conclude that IGF-1 enhances cell viability and proliferation in SK-N-SH cells via the promotion of FoxO1 nuclear export and reduction of FoxO1 binding to the GPR17 promoter via PI3K/Akt signaling. Our findings suggest that the enhancement of IGF-1 signaling to antagonize GPR17 serves as a potential therapeutic strategy in the management of acute ischemic stroke.     

Therapeutic Targeting of DNA Damage Response in Cancer

DNA damage response (DDR) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. Nevertheless, this also provides therapeutic opportunities, as cells with defective DDR signaling are directed to rely on compensatory survival pathways, and these vulnerabilities have been exploited for anticancer treatments. Following the impressive success of PARP inhibitors in the treatment of BRCA-mutated breast and ovarian cancers, extensive research has been conducted toward the development of pharmacologic inhibitors of the key components of the DDR signaling pathway. In this review, we discuss the key elements of the DDR pathway and how these molecular components may serve as anticancer treatment targets. We also summarize the recent promising developments in the field of DDR pathway inhibitors, focusing on novel agents beyond PARP inhibitors. Furthermore, we discuss biomarker studies to identify target patients expected to derive maximal clinical benefits as well as combination strategies with other classes of anticancer agents to synergize and optimize the clinical benefits.     

基于人工势场法的移动机器人路径规划研究

人工势场法是机器人局部路径规划常用的一种方法,具有反应速度快、计算量小和实时性等优点。但这种方法容易产生局部极点,导致机器人停止移动,达不到目标。文章利用传统的人工势场法对移动机器人避障行为进行了仿真实验并成功地规划出一条光滑路径,并对人工势场法研究现状进行了分析讨论。     

足球机器人路径规划的改进型人工势场算法研究

传统人工势场法不能适应复杂动态环境且容易产生局部极小,论文提出了一种改进型的人工势场算法,该算法考虑了机器人和障碍物的速度、加速度等动态特性,对传统人工势场进行了有效的调节,使其能更好地适应动态复杂环境,对局部极小问题进行判定,通过改变斥力场和引力场的影响力来解决局部极小问题,将该优化算法运用到足球机器人仿真比赛中,结果表明基于改进型人工势场优化算法能够在动态对抗性的环境中有效地实现最优路径规划,弥补了传统人工势场的不足。     

混凝土损伤本构模型研究评述

现有混凝土本构关系主要是基于成熟的经典弹塑性模型所建立的,弹塑性模型在数学上较严格,但是与混凝土材料破坏机理不协调,各国学者针对混凝土这类特殊多相复合材料提出了很多基于不可逆热力学理论的损伤本构模型。系统综述了混凝土损伤本构研究的成果,在分析了各个有代表意义的混凝土损伤本构模型基础之上,对比研究了各个模型的特点及各自适用范围,通过总结前人成果,为损伤本构模型研究提供了思路。     

氧化锌对碱性锌锰电池锌电极的影响

通过对锌电极的电性能测量和锌粉的析氢试验,揭示了氧化锌在碱性电解质中对锌的电性能有影响,且对锌有缓蚀作用,使锌的电位升高,析氢过电位增大,阳极极化增大,析氢量下降等。试验结果可能有助于改进碱性锌锰电池负极工艺。在碱性电解质中含有2%wt的氧化锌就足以满足锌负极的工艺需要。     

深层硬目标易损性的数学描述

给出了深层硬目标效能及其易损性的数学定义,表达了深层硬目标易损性研究的一种思路．通过分析侵彻爆炸毁伤作用,构造了目标完成任务能力表现水平的损失水平函数,函数形式比较简单,其数学意义与毁伤的物理现象吻合较好,通过函数分析能了解深层硬目标在侵爆综合作用下易损性的变化趋势,方便描述目标的毁伤过程．