高分子药物缓释材料

本文首先介绍了高分子药物缓释材料的分类，然后着重叙述了两类热敏性药物缓释材料的研究概况及性能特点，最后讨论了药物缓释过程的理论研究。     

Screening and construct‐specific detection methods of transgenic Huafan No 1 tomato by conventional and real‐time PCR

Genetically modified (GM) tomatoes have been approved for commercialization in many countries since the first GM tomato FLAVR SAVR was permitted for planting in 1994. In China, GM tomato Huafan No 1 with a character of long shelf‐life was the first GM plant which was approved for commercialization in 1996. To meet the requirement of the GM tomatoes labeling policy that has been actualized in China since 2001, screening and construct‐specific PCR detection methods for detecting the universal elements transformed into tomato, such as cauliflower mosaic virus 35S (CaMV35s) promoter and the nopaline synthase (NOS) terminator of Agrobacterium tumefaciens, and the specifically inserted heterologous DNA sequence between CaMV35s promoter and anti‐sense ethylene‐forming enzyme (EFE) gene were set up. To make the detection methods normative, a novel single copy tomato gene LAT52 was also used as an endogenous reference gene in the PCR detection systems. The limit of detection of screening and construct specific detection methods for Huafan No 1 was 68 haploid genome copies in conventional PCR detection, and three copies in TaqMan real‐time PCR detection. The limit of quantitation of screening quantitative PCR assays for Huafan No 1 was three copies and was 25 copies for construct‐specific quantitative PCR. Two samples with known Huafan No 1 tomato content were detected using the established conventional and real‐time PCR systems, and these results also indicated that the established Huafan No 1 screening and construct‐specific PCR detection systems were reliable, sensitive and accurate. Copyright © 2005 Society of Chemical Industry     

介孔材料在基因工程中的应用

综述了介孔材料在基因工程方面的应用研究新进展，详述了近年来国外有关介孔分子筛材料在生物传感器、药物释放和输送、固定蛋白质酶等基因工程领域的研究情况，着重介绍了介孔分子筛在固定蛋白质酶方面的应用前景，展望了国内介孔分子筛在基因工程中的应用。     

Polymers for use in drug delivery—property and structure requirements

The purpose of this paper is to discuss some of the requirements placed on materials needed for improved administration of drugs. Emphasis is placed on macromolecules that need to be designed and prepared to perform specific pharmacological functions, particularly to act as vehicles for delivering drugs to specific locations within the body. After introducing the reasons for more selective drug delivery, and explaining the rationale for using macromolecules, practical examples of results with linking drugs to polymers, modifying polymers to increase their biological compatibility, attachment to polymers of groups that could mediate their specific recognition, modification of proteins with polymers, and the use of polymer complexes will be given to indicate the areas of need for further development of pharmaceutically useful macromolecules.     

国内医院近年来中药不良反应文献分析

目的了解近年国内中药不良反应的情况和报告现状。方法通过CNKD数据文献检索,归纳、分析文献报道中各医疗机构或地区的中药ADR数据。结果中药ADR发生率在总ADR中占一定比例,注射给药、联合用药、特殊人群比例较大。结论中药的ADR不可忽视。应控制、减少中药制剂生产、保管、使用各个环节产生ADR的因素。     

生物高分子磁性微球的研究进展

磁性高分子微球是近二十年来研究的一类新型功能材料。拟从生物高分子磁性微球的制备、结构、性能和应用等几个方面综述近年来国内外有关磁性高分子微球的研究状况。     

Drug use and abuse (2nd ed.).

Review of book, Stephen A. Maisto, Mark Galizio, and Gerard J. Connors. Drug Use and Abuse (2nd ed.) Fort Worth, TX: Harcourt Press, 1995, 500 pp. Reviewed by Mitch Earleywine. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

简易防砂完井技术在渤海稠油油田的应用

在渤海疏松砂岩稠油油田,防砂和提高产量一直是一对矛盾,为了解决这一矛盾,在防砂筛管选择、适度防砂方法及度的控制、负压射孔工艺和变频启泵等方面进行了大量理论研究和试验,摸索出一整套既经济又能够最大限度提高油井产能的防砂完井新方法——简易防砂完井技术。介绍了简易防砂完井技术的原理和应用情况。在上百口井的成功应用表明,简易防砂完井技术已经日趋成熟,为渤海疏松砂岩稠油油田的开发带来了巨大的经济效益,目前该技术已经成为疏松砂岩稠油油田开发的一个重要手段。