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Smart Ferrofluid with Quick Gel Transformation in Tumors for MRI‐Guided Local Magnetic Thermochemotherapy
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Koichiro Hayashi Wataru Sakamoto Toshinobu Yogo 《Advanced functional materials》2016,26(11):1708-1718
Improved techniques for local administration of anticancer drugs are needed to reduce the side effects of chemotherapy owing to leakage of anticancer drugs from tumors and to enhance therapeutic efficacy. This study presents the development of smart ferrofluid that transforms immediately into a gel in tumors and generates heat in response to an alternating magnetic field (AMF), simultaneously releasing the anticancer drug. The smart ferrofluid, which is synthesized using less toxic magnetic materials (Fe3O4 nanoparticles), natural polysaccharides (alginate), and amino acids (cysteine), can also act as a contrast agent for magnetic resonance imaging (MRI). The ferrofluid also incorporates an anticancer drug (i.e., doxorubicin, DOX) via hydrogen bonds. AMF causes heating of gels prepared from the DOX‐containing ferrofluid, resulting in gel shrinkage and DOX release. In vivo experiments demonstrated that the ferrofluid transforms into a gel in the tumor, with the gel remaining in the tumor. Furthermore, magnetic thermochemotherapy using this ferrofluid inhibited tumor growth, while magnetic hyperthermia alone had only a marginal effect. Thus, the combination of magnetic hyperthermia and chemotherapy may be important for suppressing tumor growth. In summary, the ferrofluid presented here has the potential to facilitate MRI‐guided magnetic thermochemotherapy through a combination of endoscopic technologies in the future. 相似文献
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Euler‐Lagrangian Simulation of Magnetic Field Effects on the Mixed Convection of Ferrofluid
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In this article, the hydro‐thermal behavior of a ferrofluid flow (kerosene and 4 vol% Fe3O4) in a vertical tube in the presence of different magnetic field gradients using a two‐phase Euler–Lagrange model and control volume technique has been reported. Two cases for the magnetic field gradients have been considered to affect the mixed convection of the ferrofluid: non‐uniform axial negative and positive field gradients. Unlike our previous studies instead of uniform nanoparticle distribution within the flow, it has been considered as non‐uniform (maximum concentration profile is at the flow centerline). Based on the obtained results in this case, the velocity profiles in the negative magnetic field gradients are more affected than our previous studies. Also the time variations of the Nusselt number and skin friction factor have been presented. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res 43(2): 148‐166, 2014; Published online 12 September 2013 in Wiley Online Library ( wileyonlinelibrary.com/journal/htj ). DOI 10.1002/htj.21069 相似文献
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Hongzhang Wang Sen Chen Haowei Li Xianzhe Chen Jiashu Cheng Yunlin Shao Chenglin Zhang Jie Zhang Linlin Fan Hao Chang Rui Guo Xuelin Wang Nan Li Liang Hu Yen Wei Jing Liu 《Advanced functional materials》2021,31(32):2100274
Magnetic fields enable dexterous, precise, and real-time control of ferromagnetic materials. However, most materials, including glasses, organics, and metals, are nonmagnetic and often do not respond to a magnetic field. Here, a transitional ferrofluid (TF) made by embedding magnetic iron particles into pure gallium through the treatment of highly concentrated HCl solutions, as well as its switchable interlocking force to objects during the phase change, is introduced to achieve magnetic manipulation of non-magnetic objects. A gripper made by liquid TF enables intimate contact with arbitrarily shaped objects and then generates a strong interlocking force of as high as 1168 N (using only 10 g TF) upon solidification at room temperature, which can be reversibly eliminated (F < 0.01 N) through melting. Owing to electrical conductivity and magnetism, a solid TF can be melted through electromagnetic induction heating. By coupling the switchable physical force during the phase transition and magnetism of TF, embedded non-magnetic objects can be manipulated using an applied magnetic field and become impervious to magnetic stimuli again after heating and releasing the TF. This study is expected to inspire numerous potential applications in the reversible magnetic actuation of soft robotics, remote operation systems, drug delivery, and liquid grippers. 相似文献
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采用两步法制备了环糊精(β-Cyclodextrin)改性纳米四氧化三铁(Fe3O4)磁流体.通过在交变磁场下感应加热对其磁热稳定性进行了研究,在交变磁场下加热后悬浮裸磁颗粒或改性颗粒的磁性液体最高升温分别达到63℃和53℃,感应加热实验结果表明所制磁流体可用于肿瘤的热疗研究. 相似文献
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《Lubrication Science》2017,29(7):441-454
The present study investigates hydrodynamic lubrication by ferrofluids of finite journal bearings using the Jenkins model. A magnetic field created by displaced finite wire is used. A numerical solution for the modified Reynolds equation using the finite difference method is obtained. Static characteristics of finite journal bearings are analyzed using 2 control parameters: magnetic force coefficient and Jenkins viscosity. The obtained results are compared to those from Neurenger‐Rosensweig model. It is shown that pressure, load capacity, attitude angle, and side leakage increase and friction factor decreases when increasing the value of each control parameter at low and medium eccentricity ratios. However, the Jenkins viscosity parameter decreases the load capacity and increases the friction factor at high eccentricity ratios. 相似文献
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