多工况输气管道泄漏声波信号自适应去噪

为实现极低信噪比下管道泄漏声波信号去噪,基于多通道信号的相关性,提出使用相关系数矩阵筛选变分模态分解所得 模态分量。 针对不同工况的泄漏信号,提出不依赖真值的去噪质量评价指标,将其作为多目标灰狼优化算法目标函数,基于 Pareto 前沿获取变分模态分解的最佳模态数 K 和惩罚因子 η,实现多工况自适应去噪。 搭建了输气管道泄漏多工况实验平台,在不同工 况、不同输入信号信噪比(-8~4 dB)下验证所提方法的去噪效果。 结果表明,该方法能有效抑制噪声,-8 dB 时去噪信号信噪比提 升 2. 84 dB 以上。 对比基于单目标优化的去噪方法,-8 dB 下新方法的信噪比和相关系数分别提高了 3. 65 dB 和 31. 26% 。     

Analysis of Integrin αIIb Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains

Integrin α_IIbβ₃, a glycoprotein complex expressed at the platelet surface, is involved in platelet aggregation and contributes to primary haemostasis. Several integrin α_IIbβ₃ polymorphisms prevent the aggregation that causes haemorrhagic syndromes, such as Glanzmann thrombasthenia (GT). Access to 3D structure allows understanding the structural effects of polymorphisms related to GT. In a previous analysis using Molecular Dynamics (MD) simulations of α_IIb Calf-1 domain structure, it was observed that GT associated with single amino acid variation affects distant loops, but not the mutated position. In this study, experiments are extended to Calf-1, Thigh, and Calf-2 domains. Two loops in Calf-2 are unstructured and therefore are modelled expertly using biophysical restraints. Surprisingly, MD revealed the presence of rigid zones in these loops. Detailed analysis with structural alphabet, the Proteins Blocks (PBs), allowed observing local changes in highly flexible regions. The variant P741R located at C-terminal of Calf-1 revealed that the Calf-2 presence did not affect the results obtained with isolated Calf-1 domain. Simulations for Calf-1 + Calf-2, and Thigh + Calf-1 variant systems are designed to comprehend the impact of five single amino acid variations in these domains. Distant conformational changes are observed, thus highlighting the potential role of allostery in the structural basis of GT.     

石墨烯增强钛基复合材料制备工艺与性能研究

以多层石墨烯为增强体,通过熔炼锻造(MF)和粉末冶金(PM) 2种工艺分别制备出规格为Φ10 mm的石墨烯增强钛基复合材料棒材。石墨烯在凝固过程中以TiC枝晶形态析出,变形后呈细小颗粒,其中Ti和C原子比约为2∶1。石墨烯和球形钛粉经过机械合金化和变形加工,在基体中反应形成薄片层。MF工艺对应的棒材拉伸强度可达476 MPa,延伸率保持在28%; PM工艺对应的棒材拉伸强度可达487 MPa,延伸率保持在30%。PM工艺可形成尺寸较小的薄片状石墨烯增强体,强化作用提升,同时塑性没有显著下降。     

CFOSAT散射计几何定位验证与精度初步评估

采用STK软件对中法海洋卫星（CFOSAT）散射计几何定位算法进行了验证。针对CFOSAT散射计扇形波束扫描观测体制,分别就扇形波束扫描散射计几何定位原型算法、包含天线安装误差的完整几何定位算法利用STK进行了详细验证。结果表明了CFOSAT扇形波束散射计几何定位算法的准确性,与STK几何定位结果偏差在100 m以内。在此基础上,结合有源定标器实验数据,对CFOSAT实际观测数据几何定位参数进行了校正,给出了CFOSAT散射计几何定位精度的初步评估。     

A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes

Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master athletes when they are challenged by a single bout of prolonged moderate-intensity exercise. Six middle-aged (37Y) and five older (50Y) master highly-trained athletes performed a 24-h treadmill run (24TR). Vastus lateralis muscle biopsies were collected before and after the run and assessed for proteomics, fiber morphometry, intramyocellular lipid droplets (LD), mitochondrial oxidative activity, extracellular matrix (ECM), and micro-vascularisation. Before 24TR, muscle fiber type morphometry, intramyocellular LD, oxidative activity, ECM and micro-vascularisation were similar between master and middle-aged runners. For 37Y runners, 24TR was associated with ECM thickening, increased capillary-to-fiber interface, and an 89% depletion of LD in type-I fibers. In contrast, for 50Y runners, 24TR did not alter ECM and capillarization and poorly depleted LDs. Moreover, an impaired succinate dehydrogenase activity and functional class scoring of proteomes suggested reduced oxidative phosphorylation post-24TR exclusively in 50Y muscle. Collectively, our data support that middle-aged and master endurance athletes exhibit distinct transient plasticity in response to a single bout of ultra-endurance exercise, which may constitute early signs of muscle aging for master athletes.     

Metabolic effects in mice of cream formulation: Addition of both thickener and emulsifier does not alter lipid metabolism but modulates mucus cells and intestinal endoplasmic reticulum stress

Additives stabilize or improve the organoleptic or functional properties (or both) of many dairy products including whipping cream. Their influence on the metabolic effect of dairy cream is scarcely known. We tested the hypothesis that added emulsifier (lactic acid esters of mono- and diglycerides; MAG/DAG), thickener (carrageenan, CGN), or both, could modify the metabolic effect, notably in the intestine and liver. Nine-week-old male C57Bl/6J mice were fed UHT cream (indirect treatment) mixed with nonlipidic powder (final: 13% milkfat) for 1 or 4 wk. We compared creams (1) without additive (Ctl), (2) with thickener (Th), 0.02% of κ-CGN, and (3) with both thickener and emulsifier, 0.1% of MAG/DAG esters (Th/Em). We analyzed plasma parameters, intestine, and liver. Fasting glycemia, insulinemia, triglyceridemia, nonesterified fatty acids, body weight gain, and liver weight did not differ among groups. After 1 wk, Th/Em had higher expression in the duodenum of some of the genes involved in (1) intestinal lipid absorption and (2) tight junction proteins versus Ctl and Th. After 4 wk, mucus cell number in the small intestine was higher in Th/Em versus Ctl and Th. Genes involved in endoplasmic reticulum (ER) stress in the duodenum were more expressed in Th/Em after 1 wk. After 4 wk, in the colon, a higher expression of ER stress genes was observed for Th versus Th/Em and Ctl. Liver damage score was not altered by additives. Adding both CGN (0.02%) and MAG/DAG esters (0.1%) in dairy cream did not result in deleterious outcomes in mice after 4 wk regarding lipid metabolism, intestinal permeability, and liver disorders. The longer term effect of intestinal ER stress modulation deserves further investigation.     

离散时间奇异摄动系统的H_∞控制

研究了离散时间奇异摄动系统的H∞控制问题.通过线性矩阵不等式的求解,给出了一个H∞控制器设计方法.得到了一个充分条件,它能保证状态反馈控制器存在,使得闭环系统是渐近稳定的,并且满足一个给定的H∞范数约束.通过一个数值例子验证了方法的有效性.     

The Role of Metalloproteinases and Their Tissue Inhibitors on Ocular Diseases: Focusing on Potential Mechanisms

Eye diseases are associated with visual impairment, reduced quality of life, and may even lead to vision loss. The efficacy of available treatment of eye diseases is not satisfactory. The unique environment of the eye related to anatomical and physiological barriers and constraints limits the bioavailability of existing agents. In turn, complex ethiopathogenesis of ocular disorders that used drugs generally are non-disease specific and do not act causally. Therefore, there is a need for the development of a new therapeutic and preventive approach. It seems that matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have a significant role in the development and progression of eye diseases and could be used in the therapy of these disorders as pharmacological targets. MMPs and TIMPs play an important role in the angiogenesis, epithelial-mesenchymal transition, cell invasion, and migration, which occur in ocular diseases. In this review, we aim to describe the participation of MMPs and TIMPs in the eye diseases, such as age-related macular degeneration, cataract, diabetic retinopathy, dry eye syndrome, glaucoma, and ocular cancers, posterior capsule opacification focusing on potential mechanisms.     

损伤叶片动力参数变化规律的数值模拟与试验研究

风力发电机叶片的结构动力特性是叶片结构设计时考虑的重要方面,其动力特性对于整个风力机的安全运行具有重要意义.为了研究损伤引起的结构自振频率的变化规律,从有限元模拟以及试验两方面结合进行了研究.通过对比两种研究方法所得的固有频率值的变化规律,找出他们的共性,从而互相印证结果的正确性.结果表明,叶片的固有频率值受损伤位置、...     

螯合萃取石墨炉原子吸收光谱法测定食品中的砷

采用石墨炉原子吸收技术研究了食品中砷的测定方法。选择ＡＰＤＣ－ＭＩＢＫ萃取分离体系使砷与基体分离；采用硝酸镁＋硝酸镍作混合基体改进剂，将灰化温度提高到１１００℃，消除了共存阴、阳离子的干扰。方法检出限１．６ｎｇ／ｍｌ，２ｇ样品的最低检出浓度为６．０ｎｇ／ｇ，相对标准偏差小于１４％，平均加标回收率为９９．１±６．９％。本法具有干扰少，灵敏度高等特点。