一种去除二值文本图像边缘噪声的新方法

提出了一种去除二值文本图像边缘噪声的新厅法。该方法包括3个步骤：边缘噪声预处理,边缘噪声检测和边缘噪声去除。将该方法和其它方法作了比较。实验结果表明,该新方法可以更有效地去除边缘噪声,并在实际的文本图像处理系统中取得了较理想的效果。     

基于多智能体系统的分布式智能控制系统框架与原型系统开发

针对复杂工业过程的控制需求,研究了一种基于多智能体系统的分布式集成智能控制系统框架,系统由人机集成单元、控制单元和虚拟仿真单元构成,每个单元由分层的Agent组构成。多个专业Agent和主管Agent组成功能Agent组,通过不同的Agent激活与后备构成Agent组的重构和控制模式的切换。采用基于PC和现场总线设备相结合的硬件结构,运用遵循职能物理代理基金会组织标准的开发工具Java智能体开发框架开发原型系统,并应用到焦炉集气管压力控制实践中。工程应用表明,所提出的集成控制系统能有效地解决焦炉集气管压力这类复杂工业对象的过程控制问题。     

冶金动力旋转设备机械强度分析与状态智能监测

以焦化厂导焦除尘风机为例,对于节能改造后调速运行的大型动力旋转设备的疲劳强度进行了计算分析,结果表明,对于承受交变应力的旋转设备,应充分考虑尺寸系数和构件残余应力对所选材料疲劳强度极限值的影响,对其核心部件进行抗疲劳设计和校核工作。同时对激振力与旋转设备固有频率耦合振动的现象作了定性分析和说明。鉴于该类设备对生产工艺和产能实现的重要程度,引入了设备状态智能监测系统,对该系统的架构和功能作了阐述,并确定了下一步的主要研究方向。     

Rapid,Label-Free Prediction of Antibiotic Resistance in Salmonella typhimurium by Surface-Enhanced Raman Spectroscopy

The rapid identification of bacterial antibiotic susceptibility is pivotal to the rational administration of antibacterial drugs. In this study, cefotaxime (CTX)-derived resistance in Salmonella typhimurium (abbr. CTX^r-S. typhimurium) during 3 months of exposure was rapidly recorded using a portable Raman spectrometer. The molecular changes that occurred in the drug-resistant strains were sensitively monitored in whole cells by label-free surface-enhanced Raman scattering (SERS). Various degrees of resistant strains could be accurately discriminated by applying multivariate statistical analyses to bacterial SERS profiles. Minimum inhibitory concentration (MIC) values showed a positive linear correlation with the relative Raman intensities of I₉₉₀/I₁₃₄₈, and the R² reached 0.9962. The SERS results were consistent with the data obtained by MIC assays, mutant prevention concentration (MPC) determinations, and Kirby-Bauer antibiotic susceptibility tests (K-B tests). This preliminary proof-of-concept study indicates the high potential of the SERS method to supplement the time-consuming conventional method and help alleviate the challenges of antibiotic resistance in clinical therapy.     

Easily Established and Multifunctional Synthetic Nanobody Libraries as Research Tools

Nanobodies, or VHHs, refer to the antigen-binding domain of heavy-chain antibodies (HCAbs) from camelids. They have been widely used as research tools for protein purification and structure determination due to their small size, high specificity, and high stability, overcoming limitations with conventional antibody fragments. However, animal immunization and subsequent retrieval of antigen-specific nanobodies are expensive and complicated. Construction of synthetic nanobody libraries using DNA oligonucleotides is a cost-effective alternative for immunization libraries and shows great potential in identifying antigen-specific or even conformation-specific nanobodies. This review summarizes and analyses synthetic nanobody libraries in the current literature, including library design and biopanning methods, and further discusses applications of antigen-specific nanobodies obtained from synthetic libraries to research.     

叶片电解加工机床的研制

为了能够实现按最优进给角度加工叶片,研制出三轴进给的叶片电解加工专用机床。介绍了机床的加工原理、机床结构、性能规格以及相应的控制系统。实践证明在该机床上电解加工方料毛坯,加工出的叶片经专用量具检测,叶片型面精度符合要求。     

Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges

Acute myocardial infarction (AMI) is considered as one of the main causes of death, threating human lives for decades. Currently, its diagnosis relies on electrocardiography (ECG), which has been proven to be insufficient. In this context, the efficient detection of cardiac biomarkers was proposed to overcome the limitations of ECG. In particular, the measurement of troponins, specifically cardiac troponin I (cTnI) and cardiac troponin T (cTnT), has proven to be superior in terms of sensitivity and specificity in the diagnosis of myocardial damage. As one of the most life-threatening conditions, specific and sensitive investigation methods that are fast, universally available, and cost-efficient to allow for early initiation of evidence-based, living-saving treatment are desired. In this review, we aim to present and discuss the major breakthroughs made in the development of cTnI and cTnT specific biosensor designs and analytical tools, highlighting the achieved progress as well as the remaining challenges to reach the technological goal of simple, specific, cheap, and portable testing chips for the rapid and efficient on-site detection of cardiac cTnI/cTnT biomarkers in order to diagnose and treat cardiovascular diseases at an incipient stage.     

基于MATLAB的传动误差测试系统及其模拟实验智能化信号发生器

介绍了机械传动误差测试中数字量计数法的特点,给出了传动误差测量系统FMT的系统框图。PC机程序采用VC调用MATLAB编译后的C函数实现FFT分析,重点介绍所研制的智能脉冲信号发生器,用其产生的两路信号对实际光栅输出信号进行模拟,进而验证FMT系统测试和FFT分析的正确性,并通过实际实验进一步验证了正确性。     

论现代建筑的智能化设计

提出了智能建筑的定义及其与现代科技的关系。简述了智能建筑包含的主要技术内容。在进行初步探讨和总结的同时,介绍了有关的应用实例。     

基于锁相放大的近红外光谱信号提取电路研究

锁相放大技术(LIA)是提取微弱信号的重要方法之一,广泛应用于近红外光谱测量领域。基于光谱吸收原理设计的甲烷检测系统,利用移相技术,实现了通过调节偏置电压的大小控制测量信号与参考信号之间的相位差,通过平衡调制解调器AD630实现了相敏滤波功能,有效地抑制了干扰,提高了系统的性能。结果表明:LIA相关器输出电压与甲烷气体体积分数呈线性关系,其线性度拟合系数为0.998 5,灵敏度为0.045 7 V/%。