Identification of In Vitro Metabolites of Synthetic Phenolic Antioxidants BHT,BHA, and TBHQ by LC-HRMS/MS

Butylated hydroxytoluene (BHT) and its analogs, butylated hydroxyanisole (BHA) and tert-butyl-hydroquinone (TBHQ), are widely used synthetic preservatives to inhibit lipid oxidation in the food, cosmetic and pharmaceutical industries. Despite their widespread use, little is known about their human exposure and related biotransformation products. The metabolism of these compounds was investigated using in vitro incubations with human and rat liver fractions. Liquid chromatography coupled to high-resolution tandem mass spectrometry was employed to detect and characterize stable and reactive species formed via oxidative metabolism, as well as phase II conjugates. Several oxidative metabolites have been detected, as well as glutathione, glucuronide, and sulfate conjugates, many of which were not previously reported. A combination of accurate mass measurements, MS/MS fragmentation behavior, and isotope-labeling studies were used to elucidate metabolite structures.     

综合物探方法在天然气高瓦斯隧道超前地质预报中的应用

天然气高瓦斯隧道中的瓦斯不可预见性很大。施工过程中,在遇到隧道洞身段局部岩体节理裂隙发育、围岩破损带、断层处,均可能发生瓦斯逸出甚至瓦斯突涌现象,现场存在很大的瓦斯安全隐患。主要研究了TSP探测、地质雷达、超前钻探等方法在瓦斯隧道施工中的应用情况,多种物探手段与钻探相结合对不良地质体进行综合预测,取得了较好的预报效果,有力保障了现场施工安全。     

煤矿地面轨道运输矿车自动避障技术研究

介绍了煤矿地面轨道运输矿车自动避障技术。首先介绍了基于雷达的矿车前方障碍物检测技术及其相关算法,然后详细介绍了基于机器视觉的矿车前方障碍物检测系统和常用的图像处理方法以及相关的算法,最后介绍了雷达和机器视觉融合的障碍物检测技术在煤矿地面轨道运输矿车自动避障过程中的应用。     

基于模糊综合评判方法的水文地质类型评价

以开元矿井为例,在水文地质资料基础上,选定合适的指标,根据不同指标的重要程度确定各个指标权重,运用模糊综合评判理论建立矿井水文地质类型划分模型,运用该模型进行水文地质类型评价。     

采动影响下巷道支护参数的模拟分析及应用

潞宁煤业公司二二采区大巷在采动影响下常出现过度变形的现象.为避免在二四采区出现类似问题,以二四采区辅运大巷为背景,根据二四采区的地质条件,通过数值模拟分析,确定巷道的支护参数;实施后监测其支护效果,辅运大巷掘进期间顶底板最大移近量为63 mm,两帮为54 mm,在24102工作面采动影响下,顶板和两帮位移量分别增大了3...     

Hankel矩阵及其逆矩阵的快速三角分解算法的改进

本文改进了求Hankel矩阵及其逆矩阵三角分解的Chun-Kailath快速算法,减少了该算法的计算量,提高了精度。     

基于等参元的三维电阻抗成像的数值模拟和分析

对于电阻抗成像的数学模型,本文用等参元方法将对应的椭圆型方程离散化,把成像问题转化为非线性优化问题,给出了目标函数梯度及近似Hesee阵的计算公式;提出了伪单元刚度矩阵的概念,给出了利用其在迭代过程中的不变性来提高计算效率的方法：分别用BFGS校正拟Newton算法和Goldfeld修正Gauss-Newton算法对三维成像问题进行了一系列数值模拟实验,证实了算法的有效性,指出了其中存在的问题。     

基于等离子体反射特性的雷达诱饵技术研究

在研究等离子体与电磁波相互作用的基础上,得到了均匀非磁化等离子体对入射电磁波的反射系数,通过对反射特性的分析,讨论了等离子体用作雷达诱饵的有关问题．     

Biodegradability of lubricant base stocks and fully formulated products

Increasing awareness of the environmental impact of consumer and industrial products has produced a demand for lubricants that biodegrade. There is a number of biodegradation tests that can be used on lubricants, although not all are always appropriate, as this paper explains. The CEC test is among the best known and is in use for both conventional and synthetic oils. There will, in future, be a greater movement to biodegradable oils in Europe, perhaps extending to all oils.     

机载对海多目标ISAR成像系统设计

机载对海逆合成孔径雷达(inverse synthetic aperture radar,ISAR)能够对海面大中型舰船进行二维成像,图像信息为识别提供了更有利的依据.根据ISAR系统的工作原理,首先分析了对海多目标ISAR面临的关键问题;然后提出了空间、时间两维分割的处理方案,以解决不同海况下海面多目标成像分辨率的问...