径向水平井弯曲转向机构影响因素仿真研究

针对径向水平井钻进中钻杆弯曲转向前进运动困难的问题,通过建立弯曲转向机构仿真有限元模型,对其主要影响因素:滑道轨迹曲率、间隙、工作压力、滚轮形状与位置和钻杆壁厚等用ANSYS软件进行仿真研究。研究表明:影响截面变形的主要因素是滑道曲率的改变和滑道摩擦因数,钻井失败时钻杆所受阻力的增大不是因为升高工作压力导致截面变形过大与滑道干涉所致,钻杆经校直段,钻头中轴线与校直中心线存在一定的角度,即钻杆的前进轨迹就会偏离理论值,或与地层干涉,或可能再次发生弯曲变形;另一主要原因是转向器滑道工作恶化。增加钻杆壁厚,降低工作压力和滑道摩擦因数,设计合理弯曲转向机构是解决问题的关键。     

宽带综合IP网的MPLS技术及其应用

多协议标记交换（MPLS）技术是综合利用网络第二层交换技术的有效性和第三层IP路由的灵活性等优点而产生的多层交换技术。通过在传统的IP包里加入标记，使路由转发依赖于标记，大大地提高IP包的转发速度，同时可使传统IP网络具有服务质量（QoS）能力。现主要分析MPLS体系结构，指出MPLS的一些应用。     

非稳定井流模型的半解析解

为了提高非稳定渗流计算的计算精度 ,通过数学分析得到了水位传导系数随时间变化时 ,一类非稳定渗流井流模型的半解析解 ,并进行了计算比较     

基于CB的串行口和接口板端口程序应用

串行口及接口板端口是计算机通信的主要途径 ,也是目前计算机工程测控中通用的基本方法。C Builder (简称CB)编程语言以其功能完备、开发效率高的特点而成为目前流行的程序开发工具 ,介绍了利用CB语言编写串行口和端口通信的程序的方法 ,并对具体的各方法编写了相应的示例。     

热镀锌板(卷)工程设计中的环境保护问题

对热镀锌板(卷)的生产工艺、主要生产设备进行了简要介绍，并就其污染源(工序)、生产过程中产生的污染物及其控制措施进行了评述，同时就设计和生产中宜注意的几个环保问题进行了分析。     

一种基于空间到达角的卫星电子侦察信号分选方法

在建立简化的卫星电子侦察空间模型的基础上，提出了一种利用空间到达角分选卫星电子侦察信号的新方法。通过仿真实验验证了这种方法的可行性。该方法可用于密集信号的预处理。     

图书在版编目研究

简述了英、美等国图书在版编目的发展和中国实施在版编目的意义、作用及特点,对中国实施图书在版编目提出了设想和建议。     

Quantitative pharmacophore models with inductive logic programming

Three-dimensional models, or pharmacophores, describing Euclidean constraints on the location on small molecules of functional groups (like hydrophobic groups, hydrogen acceptors and donors, etc.), are often used in drug design to describe the medicinal activity of potential drugs (or ‘ligands’). This medicinal activity is produced by interaction of the functional groups on the ligand with a binding site on a target protein. In identifying structure-activity relations of this kind there are three principal issues: (1) It is often difficult to “align” the ligands in order to identify common structural properties that may be responsible for activity; (2) Ligands in solution can adopt different shapes (or `conformations’) arising from torsional rotations about bonds. The 3-D molecular substructure is typically sought on one or more low-energy conformers; and (3) Pharmacophore models must, ideally, predict medicinal activity on some quantitative scale. It has been shown that the logical representation adopted by Inductive Logic Programming (ILP) naturally resolves many of the difficulties associated with the alignment and multi-conformation issues. However, the predictions of models constructed by ILP have hitherto only been nominal, predicting medicinal activity to be present or absent. In this paper, we investigate the construction of two kinds of quantitative pharmacophoric models with ILP: (a) Models that predict the probability that a ligand is “active”; and (b) Models that predict the actual medicinal activity of a ligand. Quantitative predictions are obtained by the utilising the following statistical procedures as background knowledge: logistic regression and naive Bayes, for probability prediction; linear and kernel regression, for activity prediction. The multi-conformation issue and, more generally, the relational representation used by ILP results in some special difficulties in the use of any statistical procedure. We present the principal issues and some solutions. Specifically, using data on the inhibition of the protease Thermolysin, we demonstrate that it is possible for an ILP program to construct good quantitative structure-activity models. We also comment on the relationship of this work to other recent developments in statistical relational learning. Editors: Tamás Horváth and Akihiro Yamamoto     

Improving the Calibration of Vacuum Gas Flow – Control Leak Gauges

A new and original method of calibrating helium leaks that makes it possible to take into account the existence of a number of auxiliary phenomena is described. For this purpose, a hollow leak the purpose of which is to reproduce only desorbed gas flows, is introduced into the vacuum system of the calibration bench. Analysis of the results of corresponding cumulation measurements makes it possible to introduce corrections for these phenomena.     

Measurement and Identification of the Parameters of SPICE-Models of a Bipolar Transistor

A method of measuring and identifying the static parameters of a bipolar transistor is considered. The characteristic of the transistor, from which the parameters of the model are determined, is chosen depending on what group the calculated parameters belong to. The characteristics are measured in such a way that the equations of the model describing them can be reduced to the simplest form.