TPT药品包装用铝箔粘合剂的研制

采用聚酯树脂、VMCH树脂、溶剂等制成TPT药品包装用铝箔粘合剂。介绍了聚酯树脂的生产工艺、粘合剂的制备及性能,讨论了各种影响因素。     

不同种玉米淀粉在杜仲精油中的应用研究

中药精油,一般是指从中药植物中提取的挥发性芳香物质。但中药精油的使用目前一般是以外用涂抹为主,剂型选择与使用方式都受到很大的限制。为创新杜仲精油的给药途径,本实验以生物法制备的玉米淀粉为基础,通过酶法制备多孔淀粉和醇法制备V型结晶淀粉,再分别与杜仲精油复合制备杜仲粉末精油,对比研究了不同种玉米淀粉在杜仲精油中的应用情况。结果显示,多孔玉米淀粉与杜仲精油的复合指数为44%,明显高于其他两种玉米淀粉;结晶性质表明所有的粉末精油都在20.5的2θ处出现新的吸收峰,说明了复合形成了新的V型结构,其中多孔玉米淀粉粉末精油的强度较其他两种粉末精油更强;热力学性质中的焓值增加也说明了复合物形成了新的化学结构,其中多孔玉米淀粉粉末精油的焓值是最高的;红外扫描中出现新的特征峰进一步证实了玉米淀粉粉末精油产生了新的化学键,其中多孔玉米淀粉粉末精油显示出最强的吸收峰。     

薄壁药盒成形工艺与模具设计

分析了薄壁药盒的成形工艺,对其中的关键工序,采用双拉伸一次拉伸成形。对斜楔及内外滑块同时压出18个凹面体的模具结构和模具主要零件的设计作了介绍。     

色谱—质谱联用技术在中药研究中的应用

本文从GC—MS、HPLC—MS、CE—MS三方面阐述了色谱联用技术在中药研究中的应用。     

基于无意识设计理念的老年人提醒药盒设计

目的对无意识设计理念的研究与分析,实现老年人提醒药盒设计的应用价值,拓展老年人产品的消费需求和市场机会。方法以无意识设计理念理解为基础,从产品与用户行为的协调性、产品与环境的协调性两个方面出发,比较无意识设计理念与老子"无为而治"哲学思想之间的关联性。通过对深泽直人无意识设计案例研究与归纳,从生理、心理和精神三个方面进行老年人用户分析,解决老年人提醒药盒的功能需求和情感需求。结论基于无意识设计理念的老年人提醒药盒设计实践与研究,可以为未来老年人消费产品发展提供一种行之有效的思考方式和设计方法,同时唤起社会对于老年人消费市场的关注和重视,提高老年人消费市场的设计水平,对实现社会可持续发展具有重要的借鉴意义。     

State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan

Lung cancers are life-threatening malignancies that cause great healthcare burdens in Taiwan and worldwide. The 5-year survival rate for Taiwanese patients with lung cancer is approximately 29%, an unsatisfactorily low number that remains to be improved. We first reviewed the molecular epidemiology derived from a deep proteogenomic resource in Taiwan. The nuclear factor erythroid 2-related factor 2 (NRF2)antioxidant mechanism was discovered to mediate the oncogenesis and tumor progression of lung adenocarcinoma. Additionally, DNA replication, glycolysis and stress response are positively associated with tumor stages, while cell-to-cell communication, signaling, integrin, G protein coupled receptors, ion channels and adaptive immunity are negatively associated with tumor stages. Three patient subgroups were discovered based on the clustering analysis of protein abundance in tumors. The first subgroup is associated with more advanced cancer stages and visceral pleural invasion, as well as higher mutation burdens. The second subgroup is associated with EGFR L858R mutations. The third subgroup is associated with PI3K/AKT pathways and cell cycles. Both EGFR and PI3K/AKT signaling pathways have been shown to induce NRF2 activation and tumor cell proliferation. We also reviewed the clinical evidence of patient outcomes in Taiwan given various approved targeted therapies, such as EGFR-tyrosine kinase inhibitors and anaplastic lymphoma kinase (ALK)inhibitors, in accordance with the patients’ characteristics. Somatic mutations occurred in EGFR, KRAS, HER2 and BRAF genes, and these mutations have been detected in 55.7%, 5.2%, 2.0% and 0.7% patients, respectively. The EGFR mutation is the most prevalent targetable mutation in Taiwan. EML4-ALK translocations have been found in 9.8% of patients with wild-type EGFR. The molecular profiling of advanced NSCLC is critical to optimal therapeutic decision-making. The patient characteristics, such as mutation profiles, protein expression profiles, drug-resistance profiles, molecular oncogenic mechanisms and patient subgroup systems together offer new strategies for personalized treatments and patient care.     

Fabrication of cell patches using biodegradable scaffolds with a hexagonal array of interconnected pores (SHAIPs)

Cell patches are widely used for healing injuries on the surfaces or interfaces of tissues such as those of epidermis and myocardium. Here we report a novel type of porous scaffolds made of poly(d,l-lactic-co-glycolic acid) for fabricating cell patches. The scaffolds have a single layer of spherical pores arranged in a unique hexagonal pattern and are therefore referred to as “scaffolds with a hexagonal array of interconnected pores (SHAIPs)”. SHAIPs contain both uniform pores and interconnecting windows that can facilitate the exchange of biomacromolecules, ensure homogeneous cell seeding, and promote cell migration. As a proof-of-concept demonstration, we have created skeletal muscle patches with a thickness of approximately 150 μm using SHAIPs. The myoblasts seeded in the scaffolds maintained high viability and were able to differentiate into multi-nucleated myotubes. Moreover, neovasculature could efficiently develop into the patches upon subcutaneous implantation in vivo.     

The Applications and Fabrication Methods of 90Sr/90Y Sources

The applications of ⁹⁰Sr/⁹⁰Y sources were reviewed on clinical medicine, thickness gauge, continuous energy supply for science and industry, reference source for contamination calibration. The application of each source proposes certain requirement for the source properties, and that could be realized by some corresponding preparation method. Different⁹⁰Sr/⁹⁰Y source preparation methods for each application were introduced, and the characteristics of them were contrasted.     

民族院校中医药人才培养方案及课程体系探究

民族地区必须适应社会对中医药职业岗位的需求,适应终身教育需要和未来职业演变的趋势。改进现有的人才培养模式,适当增加需要的医学课程,整合和优化教学内容,在专业实践技能体现"针对性"和"实用性"的实践教学体系,构建适应21世纪的高职中药专业人才培养方案和课程体系。     

石墨炉原子吸收光谱法测定两种彝药中的镉

试验采用微波消解技术消化样品,用石墨炉原子吸收光谱法测定了牛口刺和翻白草中的镉含量。对干燥温度、灰化温度、原子化温度等仪器工作参数进行了试验,得出了最佳测定条件。测定中选用磷酸二氢氨作为基体改进剂,分别测定了两种彝药中镉元素的含量。分析结果表明,两种彝药中镉的含量不同：牛口刺为0.191μg/g,翻白草为0.407μg/g,两种彝药中Cd的加标回收率在95.5%~98.2%之间。