一种新的边界检测方法及其在核医学图象定量分析中的应用

本文对过去若干种边界检测方法的实验对比基础上,并结合TL-201心肌灌注图象的处理,提出一种新的边界检测方法,即“改进的RS方法”。实验证明,该方法对噪声和干扰具有很高的抑制作用,并适合其它应用领域。迭代法计算边界重心,以及快速傅里叶变换边界优化,使该方法更为客观、可靠。由此方法所得到的边界,可满意地用于核医学图象的定量分析。     

The two-way feedback and passing way of human body

The sensation of two-way feedback of body [1] is a special system of human reaction, which maintains and regulates symmetry and balance of human body. The human two-way feedback reacts to human health. For human health we must pay attention to the stimulations (passive acceptance and initiative interventions) and relevant influences in human body and the stimulative effect. In this paper, the experimental research of stimulation and an example of two-way feedback in human body are given. And lay a foundation of prevention, medical treatment and hygiene of human body.     

The Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology

Microgravity-induced bone loss is currently a significant and unresolved health risk for space travelers, as it raises the likelihood for irreversible changes that weaken skeletal integrity and the incremental onset of fracture injuries and renal stone formation. Another issue related to bone tissue homeostasis in microgravity is its capacity to regenerate following fractures due to weakening of the tissue and accidental events during the accomplishment of particularly dangerous tasks. Today, several pharmacological and non-pharmacological countermeasures to this problem have been proposed, including physical exercise, diet supplements and administration of antiresorptive or anabolic drugs. However, each class of pharmacological agents presents several limitations as their prolonged and repeated employment is not exempt from the onset of serious side effects, which limit their use within a well-defined range of time. In this review, we will focus on the various countermeasures currently in place or proposed to address bone loss in conditions of microgravity, analyzing in detail the advantages and disadvantages of each option from a pharmacological point of view. Finally, we take stock of the situation in the currently available literature concerning bone loss and fracture healing processes. We try to understand which are the critical points and challenges that need to be addressed to reach innovative and targeted therapies to be used both in space missions and on Earth.     

Hybrid Graphene-Gold Nanoparticle-Based Nucleic Acid Conjugates for Cancer-Specific Multimodal Imaging and Combined Therapeutics

Nanoparticle-based nucleic acid conjugates (NP-NACs) hold great promise for theragnostic applications. However, several limitations have hindered the realization of their full potential in the clinical treatment of cancer and other diseases. In diagnoses, NP-NACs suffer from low signal-to-noise ratios, while the efficiency of NP-NACs-mediated cancer therapies has been limited by the adaptation of alternative prosurvival pathways in cancer cells. The recent emergence of personalized and precision medicine has outlined the importance of having both accurate diagnosis and efficient therapeutics in a single platform. As such, the controlled assembly of hybrid graphene oxide/gold nanoparticle (Au@GO NP)-based cancer-specific NACs (Au@GO NP-NACs) for multimodal imaging and combined therapeutics is reported. The developed Au@GO NP-NACs show excellent surface-enhanced Raman scattering (SERS)-mediated live-cell cancer detection and multimodal synergistic cancer therapy through the use of photothermal, genetic, and chemotherapeutic strategies. Synergistic and selective killing of cancer cells are then demonstrated using in vitro microfluidic models. Moreover, with the distinctive advantages of the Au@GO NP-NACs for cancer theragnostics, precision cancer treatment through the detection of cancer cells in vivo using SERS followed by efficient ablation of tumors is shown. Therefore, the Au@GO NP-NACs can pave a new road for advanced disease theragnostics.     

Biodegradable Hydrophobic Injectable Polymers for Drug Delivery and Regenerative Medicine

Biodegradable, hydrophobic, and injectable liquid polymers are capable of achieving the minimally invasive, sustained, and local release of drugs. These hydrophobic injectable polymers also have potential in the area of regenerative medicine where the biomaterial should be stable for a certain period and then degrade to allow the growth of cells/tissues. This review presents exclusive coverage of biocompatible hydrophobic injectable pasty or liquid polymers that can be injected without the use of any solvent for drug delivery, tissue augmentation, and regenerative medicine application. The synthesis methodologies of several major types of hydrophobic pasty polymers used in the biomedical fields and their properties with the foremost criteria to serve as injectable biomaterial for localized drug delivery and regenerative medicine is described. The hydrophobic biodegradable injectable polymers discussed are aliphatic polyesters, polycarbonates and polyanhydrides, prepared from: lactic acid, glycolic acid, caprolactone, aliphatic diols and diacids, hydroxy fatty acids, and triglycerides such as castor oil.     

阻焊油墨塞孔工艺能力提升研究

塞孔技术目前已经广泛为应用于各类PCB产品。虽然应用较早,但由于塞孔工艺和方法涉及面广,品质控制不易,塞孔不饱满,塞孔气泡,塞孔裂缝等问题极大影响了孔的可靠性。本文主要研究不同塞孔方式的选择和不同的塞孔工艺(阻焊油墨塞孔、半塞孔、树脂塞孔等),提升厚径比≥10:1过孔塞孔能力,改善塞孔不良导致药水残留腐蚀孔壁的可靠性风险。     

粒度对食品医药用硅藻土助滤剂渗透性能的影响

为了给GB 24265-2009的逐步完善提供参考,以临江硅藻土助滤剂厂产食品医药用助熔焙烧品硅藻土助滤剂（ZBS）和食品医药用焙烧品硅藻土助滤剂（BS）为试样,采用硅藻土助滤剂渗透率测试装置考察了粒度对它们渗透性能的影响。结果表明,两种试样的渗透率随粒度的变化都可以用呈正比例关系的线性方程描述,但ZBS试样的粒度对渗透率影响更显著,而且在相同粒度下,ZBS试样的渗透率高于BS试样的渗透率。由渗透率与粒度关系的线性回归方程,得出食品医药用ZBS的d₅₀范围应为24.6~131.4 μm,食品医药用BS的d₅₀范围应为2.9~79.8 μm。     

白三烯与生物机体衰老

生物机体衰老是自发的、必然的自然现象,表现为机体结构和机能的衰退、适应能力和抵抗力的减退,机体衰老通常伴随着炎症介质的低度慢性上调。白三烯(Leukotrienes,LTs)是一类具有高度生物活性的花生四烯酸衍生物,是一种重要的炎症介质,参与了随年龄增加的各类慢性炎症的发生过程。本文就白三烯的生物学作用及其与机体组织器官衰老的相关性研究进展进行综述。     

江西省县级中医院人力资源状况的分析

目的了解江西省县级中医院人力资源分布,评估县级中医院＂卫生服务能力建设工程＂的实施效果。方法采用普查问卷的方式分别收集2007年和2010年江西省县级中医院卫生人力资源数据,用统计软件SPSS 13.0对所获数据进行分析比较。结果与2007年相比,2010年江西省县级中医院的卫生技术人员有所增加,占每院平均职工总数的86.4%;医生与护理人员的比例尚未达标（1∶0.89）,中医药人员比例严重失调,但正逐步趋向合理。职称方面：各医院均以中级和初级居多（73.80%）,而高级职称极少（5.97%）;学历方面：除个别中医院有极少量的硕士、博士生外（0.02%）,绝大多数中医院均以大、中专毕业生为主（77.55%）。结论实施＂卫生服务能力建设工程＂以来,江西省县级中医院医护人员数量有所增加,医护人员结构配置更趋合理,但仍然存在高学历人员缺乏、人员结构方面重医疗轻护理等问题。     

Medically-derived (131)I in municipal sewage effluent

This work presents ¹³¹I (t_½ = 8.04 d) concentrations in sewage effluent from the Stony Brook Water Pollution Control Plant (WPCP), a small plant serving a regional thyroid cancer treatment facility in Stony Brook, NY, USA. The concentrations detected in sewage effluent ranged from 1.8 ± 0.3 to 227 ± 2 Bq L⁻¹. The primary source of ¹³¹I is excreta from thyroid cancer inpatients treated at the Stony Brook University Medical Center. Based on several time series measurements following known inpatient treatments, the mean sewage half-life (T_s) of iodine is 3 d in this plant. The T_s, analogous to a radioactive half-life, describes the time it takes for half of a wastewater component to be removed from a WPCP. Flow recycling, or activated sludge, used to maintain bacterial populations necessary for sewage treatment causes iodine to remain in this plant far longer than its hydraulic retention time. The experimental results suggest that most ¹³¹I entering the Stony Brook WPCP leaves in sewage effluent, not in sewage sludge. Patient treatments can result in continuous discharges of ¹³¹I to surface waters where it can be used as a tracer of sewage-derived material and to understand the behavior of ¹³¹I in aquatic environments.