基于Legendre多项式的随机连续系统的Markov参数估计

本文在讨论连续Ｗｉｓｅｎｒ过程的Ｌｅｇｅｎｄｒｅ多项式逼近值的相关性和Ｗｉｅｎｅｒ过程扰动下连续线性系统基于该正交多项的最小二乘估计有偏性后，提出了无偏一致的且数估计误差方差最小的Ｍａｒｋｏｖ估计（最小方差估计）算法，并给出本文方法的仿真结果。     

正交试验法于优选白瓷坯料配方中的应用

对长石、石英、龙岩土、莱阳土４种因素各取４个水平，用正交表Ｌ１６（４５）安排１６个试验，分析了这１６个试验产品的吸水率、白度、热稳定性与每种因素各水平之间的关系．得出了白瓷坯料的最佳配方。其中，长石１９，石英２１，龙岩土２１．莱阳土０．     

气门用4Cr9Si2钢调质工艺研究

采用正交试验 ,研究了 4Cr9Si2钢的淬火温度、回火温度与组织、硬度间的关系 ,得出了最佳的工艺参数 (10 10℃淬火 ,6 0 0℃回火 )。实际生产表明 ,采用此工艺后 ,断裂现象基本消除 ,气门的热处理质量有了明显提高。     

层状介质中重力,地震联合反演的迭代算法

本文提出一种用于层状介质中重力、地震资料联合反演层速度、层密度及弯曲界面深度的迭代算法。该方法通过引入加权最小平方目标泛函,将层状介质中的重力、地震资料联合反演问题转化成具体的优化问题。为了得到反问题的最优解,文中系统地研究了层状介质中双摄动处理技术,以及层状介质中波场摄动的一阶 Born 近似解与理论重力异常摄动解。并应用 Tarantola 的反演理论,导出了梯度算子的计算公式。然后应用最速下降法给出了求取最优解的具体算法,得到了一种类似于地震偏移与空间更投影的迭代反演方法。对理论模型进行重力、地震联合反演的结果表明,该方法不仅可碱少未知参数的个数,提高反演的收敛速度,而且可减少反演的不适定性,不失为一种可行的多参数反演方法。     

偏最小二乘回归在气温预测中的研究与应用

气温的预测要考虑多重气象因子,然而各气象因子间的多重相关性导致普通的多元回归模型失真,预测精度降低。为了解决以上问题,本研究采用偏最小二乘回归(Partial Least Squares Regression,简称PLS)建模,根据实际建模需要对算法进行改进。为了验证该模型,本研究以成都市10月份气温场为预报场,并结合成都市13个自动站气温数据,提取预报所需主要因子,进行PLS回归建模。实验表明该模型有较好的预测能力。     

银耳多糖超声波提取工艺优化及抗BV2细胞炎症的作用研究

以银耳为原料, 采用超声波辅助热水浸提法提取银耳多糖, 以多糖提取率为指标, 以超声波功率、提取料液比、提取温度和提取时间为影响因素, 设计单因素试验, 并通过正交试验得到较佳提取工艺。通过用TRPV1(Transient Receptor Potential Vanilloid1)试剂盒检测了小胶质细胞TRPV1的释放水平, 与脂多糖(Lipopolysaccharide, LPS)对照组相比, 不同质量浓度的银耳多糖组(62.5, 250, 1000 μg/mL)均能不同程度地抑制TRPV1的释放量。说明了银耳多糖对于BV2小胶质细胞炎症具有良好的抑制作用。     

Natural Polysaccharides as Multifunctional Components for One-Step 3D Printing Tough Hydrogels

Natural polysaccharides (NPS) are regarded as biomolecular and structural components for preparing high-performance tough hydrogels. But the one-step fabrication of NPS-containing hydrogels in seconds and the template-free design of complicated high-resolution structures are still significant challenges in this field. To meet these requirements, various NPS-containing tough hydrogels are fabricated and processed into 2D/3D structures via the combination of Ru(bpy)₃²⁺-mediated photochemistry and extrusion 3D printing technique. The whole fabrication process is one-step, completed in tens of seconds under visible light irradiation. It is found that the used NPS plays a key role in achieving the fabrication of high-performance structured tough hydrogels. The high reactivity of functional groups in the used NPS can shorten their gelation times. Long rigid chains of the used NPS, their hierarchical assemblies, and contrasting multinetworks benefit from the efficient dissipation of mechanical energy and enhancement of its operational stability. Strong supramolecular interactions enable hydrogel precursors to have high viscosities, therefore providing good controllability to design high-resolution and complicated tough hydrogel structures via extrusion 3D printing. It is anticipated that this straightforward fabrication strategy and findings will open new horizons for NPS-containing materials.     

Multicomponent Bioluminescence Imaging with Naphthylamino Luciferins

Bioluminescent tools have been used for decades to image processes in complex tissues and preclinical models. However, few distinct probes are available to probe multicellular interactions. We and others are addressing this limitation by engineering new luciferases that can selectively process synthetic luciferin analogues. In this work, we explored naphthylamino luciferins as orthogonal bioluminescent probes. Three analogues were prepared using an optimized synthetic route. The luciferins were found to be robust emitters with native luciferase in vitro and in cellulo. We further screened the analogues against libraries of luciferase mutants to identify unique enzyme-substrate pairs. The new probes can be used in conjunction with existing bioluminescent tools for multi-component imaging.     

基于数值模拟的等效拉延筋设计与优化

拉延筋在汽车覆盖件拉深成形中起着十分重要的作用。利用拉延筋可以在较大范围内调节和控制板料的变形程度和变形分布,抑制破裂、起皱、面畸变等多种冲压质量问题的产生。在很多情况下,拉延筋的设置合理与否将决定覆盖件拉深的成败。文章借助eta/DYNAFORM软件,模拟某轿车B柱加强板在无/有拉延筋的模具上进行拉深的全过程,通过模拟结果分析比较,确定拉延筋的合理布局及数量,最后结合正交实验法,优化拉延筋的结构参数。     

用正交实验设计研究Zr—Nb合金的耐蚀性

利用正交设计实验的方法安排了一组Ｚｒ－Ｎｂ二元合金，考查了两个水平的Ｎｂ含量，淬火温度，时效温度，时间以及合金组织状态对耐蚀性能的影响，５００℃蒸汽腐蚀结果表明，Ｎｂ含量控制在固溶极限范围内Ｚｒ－Ｎｂ二元含金具有较佳的耐蚀性，而当Ｎｂ含量较高时，采用双相区淬火，较高温度长时间时效处理是获得较好耐蚀性的工艺方向。