One of the Primary Functions of Tissue-Resident Pluripotent Pericytes Cells May Be to Regulate Normal Organ Growth and Maturation: Implications for Attempts to Repair Tissues Later in Life

Adult mesenchymal stem cells were reported more than 30 years ago. Since then, their potential to repair and regenerate damaged or diseased tissues has been studied intensively in both preclinical models and human trials. Most of the need for such tissue repair/regeneration is in older populations, so much of the effort has been performed with autologous cells in older patients. However, success has been difficult to achieve. In the literature, it has been noted that such progenitor cells from younger individuals often behave with more vigorous activity and are functionally enhanced compared to those from older individuals or animals. In addition, cells with the characteristics of mesenchymal stem cells or pluripotent mesenchymal regulatory cells exist in nearly all tissues and organs as pericytes since fetal life. Such evidence raises the possibility that one of the primary roles of these organ-specific cells is to regulate organ growth and maturation, and then subsequently play a role in the maintenance of organ integrity. This review will discuss the evidence to support this concept and the implications of such a concept regarding the use of these progenitor cells for the repair and regeneration of tissues damaged by injury or disease later in life. For the latter, it may be necessary to return the organ-specific progenitor cells to the functional state that contributed to their effectiveness during growth and maturation rather than attempting to use them after alterations imposed during the aging process have been established and their function compromised.     

发动机连杆裂解加工初始裂纹槽几何参数研究

分析比较了裂纹槽的设计位置、几何形状以及预制方法;对含有预制裂纹槽的C70S6钢连杆的裂解加工过程进行了数值模拟分析和连杆断裂剖分实验,给出裂纹槽几何参数对裂解力水平的影响规律.结果表明,在其他参数不变的条件下,裂纹槽深度对裂解力的影响最为显著,随着槽深增大裂解力锐减;提高锐度及减小张角可降低裂解力,但曲率半径为0.1~0.3 mm或张角>30°时,裂解力增幅较小且趋于稳定.研究结果对合理设计裂纹槽、降低切槽成本、提高连杆裂解质量具有参考价值.     

汽车转向拉杆断裂失效分析

某车辆在一次轮侧碰撞事故中,其转向拉杆在与梯形臂连接的螺纹处发生断裂。通过宏观检查、化学成分分析、显微组织分析、断口扫描电镜分析以及建立其力学模型进行稳定计算并综合分析后认为,该拉杆具有早期缺陷。很大程度上降低了其安全系数。在有缺陷的情况下,横拉杆的稳定极限载荷为24．41kN,承载能力较其正常稳定极限载荷50．23kN下降了51．4％。该转向拉杆在此次事故中受到冲击载荷,在横截面积最小处即连接螺纹处发生失稳,最终断裂失效。     

Modeling and finite element analysis of rod and wire steel rolling process

Two thermomechanical coupled elastic-plastic finite element （FE） models were developed for predicting the 12-pass continuous rolling process of GCrl 5 rod and wire steel. The distances between stands in the proposed models were set according to the actual values, and the billets were shortened in the models to reduce the calculation time. To keep the continuity of simulation, a technique was developed to transfer temperature data between the meshes of different models in terms of nodal parameters by interpolation functions. The different process variables related to the rolling process, such as temperature, total equivalent plastic strain, equivalent plastic strain rate, and contact friction force, were analyzed. Also, the proposed models were applied to analyze the reason for the occurrence of an excessive spread in width. Meanwhile, it was also utilized to assess the influence of the roll diameter change on the simulated results such as temperature and rolling force. The simulated results of temperature are found to agree well with the measured results.     

有一个紧固件的半无限板孔周应力有限元分析

用有限元法计算了有一个紧固件孔的半无限平板在紧固件力作用下的孔周应力．在紧固件与孔之间的接触区域的结点间加无长刚杆元．用反复计算的方法确定接触范围；计算出孔周应力等，并与文献［１］的实验结果进行了比较．     

半连续轧制纯镍线棒材的宽展分析

本文主要通过介绍金属轧制宽展构成及影响宽展的因素,利用典型宽展计算基本方法和参数,对纯镍盘圆半连续孔型轧制过程中椭圆一圆孔型系的宽展实际生产情况进行分析,并对轧制孔型设计优化。     

CAP1400控制棒提升极限分析方法研究

控制棒提升极限用于限定控制棒组棒位和可溶硼浓度的范围,以防止慢化剂温度系数突破限值。CAP1400核电厂采用机械补偿运行策略,使控制棒及硼浓度运行范围大为扩展,同时功能独立的M棒组和AO棒组同时插入堆芯使得插棒情况更为复杂,因此与传统核电厂相比,CAP1400核电厂的控制棒提升极限更难界定。本文建立了适用于CAP1400核电厂的控制棒提升极限分析方法,并给出计算结果。本文提出的方法合理地解决了复杂的控制棒运行情况给提升极限造成的影响,并充分地利用了电厂实测数据对提升极限进行修正。基于本文方法得到的提升极限精确且具备一定的保守性,所以便于电厂实际运行时使用。     

高温气冷堆舱室抗商用飞机撞击的耦合数值分析

本文建立了大型商用飞机撞击典型高温气冷堆核电站反应堆舱室的非线性有限元模型,计算中混凝土舱室直接采用工程用钢筋混凝土的损伤塑性本构模型,飞机结构采用Johnson-Cook本构模型。对飞机高速撞击高温气冷堆核电站反应堆舱室非线性撞击过程进行模拟计算,得出正面和侧面撞击条件下的撞击载荷曲线、撞击位移云图、反应堆舱室混凝土破坏情况等结果。评估表明,反应堆舱室结构在撞击条件下的整体损伤微小,可为保护内部关键设备提供重要的屏障功能。