The Thousand Polish Genomes—A Database of Polish Variant Allele Frequencies

Although Slavic populations account for over 4.5% of world inhabitants, no centralised, open-source reference database of genetic variation of any Slavic population exists to date. Such data are crucial for clinical genetics, biomedical research, as well as archeological and historical studies. The Polish population, which is homogenous and sedentary in its nature but influenced by many migrations of the past, is unique and could serve as a genetic reference for the Slavic nations. In this study, we analysed whole genomes of 1222 Poles to identify and genotype a wide spectrum of genomic variation, such as small and structural variants, runs of homozygosity, mitochondrial haplogroups, and de novo variants. Common variant analyses showed that the Polish cohort is highly homogenous and shares ancestry with other European populations. In rare variant analyses, we identified 32 autosomal-recessive genes with significantly different frequencies of pathogenic alleles in the Polish population as compared to the non-Finish Europeans, including C2, TGM5, NUP93, C19orf12, and PROP1. The allele frequencies for small and structural variants, calculated for 1076 unrelated individuals, are released publicly as The Thousand Polish Genomes database, and will contribute to the worldwide genomic resources available to researchers and clinicians.     

超、高超声速大长细比飞行器气动特性快速计算

将牛顿碰撞类方法推广应用于超、高超声速细长体导弹的气动特性预测.根据飞行器的外形特征,将外形分成几个部分,根据各自几何特点和流场特性,对不同部分及其迎风面和背风面选用不同的方法,计算方法适用于Ma=3~25、攻角0~30°范围内大长细比导弹类飞行器的气动力特性快速计算.经过与风洞试验数据的对比,证明此方法具有计算速度快、精度高的特点.     

基于多元非线性回归算法的动车组变压器温度预测研究

对动车组状态参数进行预测是实现动车组数字化精准维修的重要前提之一.目前对动车组数据的利用方式主要以定量观测和定性分析为主,缺乏准确的状态预测量.为此,文章提出了一种基于多元非线性回归的预测算法,通过建立变压器温度预测模型,实现了变压器温度值的次日预测,并以此指导由温度导向的变压器日常运维项目.通过对比CRH5A型动车组...     

圆高强钢管UHPC梁抗弯性能研究

高强钢管高强混凝土的应用越来越广泛,但目前对于其徐变特性的试验研究较少。该文对15根不同含钢率的高强钢管高强混凝土轴压短柱进行了365 d的收缩和徐变测试,并将试验结果与常用的徐变预测模型MC90、ACI209和MC2010等进行了对比。试验结果表明：高强钢管高强混凝土的徐变系数远小于素混凝土,当加载365 d后,素混凝土的徐变系数是高强钢管高强混凝土的2倍以上;含钢率对钢管混凝土试件的徐变有一定影响,徐变系数随着含钢率的增大而减小。在对比的3种常用徐变预测模型中,MC2010模型的徐变预测结果与试验结果吻合最好,可推荐用于高强钢管高强混凝土的收缩和徐变效应计算。此外,还将高强钢管高强混凝土与普通钢管混凝土的徐变试验结果进行了对比,结果表明,钢管混凝土的徐变随着核心混凝抗压强度的增加而减小。研究成果可为高强钢管高强混凝土轴心受压构件在正常使用阶段的徐变预测及徐变变形控制提供依据。     

用Weibull模型预测油气田(藏)早期开发指标

油气田(藏)开发早期很难进行开发方案的设计。作者根据探明储量、最大产量、假定采收率、生产年限,提出了采用Weibull开发模型进行油气田(藏)早期开发指标预测的方法,制作了Q_maxt_R/N_o-E_R图版,并根据该图版求取增长指数b,制定了Weibull开发模型的开发方案。     

Life Prediction Based on Transient Dynamics Analysis of Van Semi-trailer with Air Suspension System

The early fatigue damage in the van-body of the semi-trailer is often caused by the unique mechanical characteristics and the dynamic impact of the loads.The traditional finite element method with static strength analysis cannot support the fatigue design of van-body;thus,the dynamics analysis should be adopted for the endurance performance.The accurate dynamics model to describe the transient impacts of all kinds of uneven road and the proper system transfer functions to calculate the load transfer effects...     

基于聚类克隆技术的Markov预测算法的改进

为解决传统一阶Markov模型算法的预测准确率较低问题,改进算法在动态的基于聚类克隆的Markov模型算法的基础上,通过限制克隆条件实现对状态的过滤,减少了需克隆的状态数,减小了计算量,从而提高了运算速度.实验表明,这种策略能有效地提高Markov模型在网页预测中的效率.     

Choice of a pertinent color space for color texture characterization using parametric spectral analysis

This article presents a comparison of different color spaces including RGB, IHLS and L?a*b* for color texture characterization. This comparison is based on the fusion of the independent spatial structure and color feature cues. In IHLS and L*a*b*, two channel complex color images are created from the luminance and the chrominance values. For such images, two dimensional complex multichannel linear prediction models are used to perform parametric power spectrum estimation and the structure feature cues are computed from this estimated power spectrum. Quantitative comparison of auto spectra of luminance and combined chrominance channels for different color spaces is done. This comparison is based on the degree of decorrelation between luminance and chrominance information provided by different color space transformations. Three dimensional histograms are used as color feature cues. Then, to classify color textures, Kullback-Leibler divergence based symmetric distance measures are calculated for pure color, luminance structure and chrominance structure feature cues. Individual as well as combined effect of information from all feature cues on classification results is then compared for different color spaces and different color texture data sets. The proposed color texture classification method performs better than the state of the art methods in certain cases. The L*a*b* color space gives us a better characterization of the chrominance spatial structure as well as the overall spatial structure for all of the chosen data sets. Experimental results on pixel classification of color textures are also presented and discussed.     

考虑调峰和电网输送约束的省级系统风电消纳能力分析

随着风电并网容量的增加,调峰和电网输送能力已成为电力系统消纳风电的瓶颈。为直观表达省级系统消纳风电的能力,指导风电发展规划以及未来调度运行工作,结合中国电力系统运行特性,研究了综合考虑调峰约束和电网输送能力约束的风电电量消纳预测方法,并根据中国北方风电富集省份现有的电网条件、电源结构、实际运行方式等信息,对多种场景下两...     

电力市场环境下中长期负荷预测的应用分析

电力市场环境下负荷预测误差风险直接影响售电公司经营效益和供电的安全性和稳定性.为提高售电公司的经济性和稳定性,从负荷预测误差与负荷类型的研究角度出发,利用灰色系统理论、最小二乘支持向量机模型对中长期负荷进行了预测,并提出了预测加权误差这一概念,重点讨论某地区主要负荷类型与其预测加权误差之间的关联关系.分析结果使得负荷预...