Nanosecond laser operation by spectroscopical parameters of the oxadiazole derivatives

We have studied the variation of principal spectroscopic parameters (absorption edge, spectral positions of the first three principal bands, oscillator strengths) for three oxadiazoles (pyrazoloquinoline derivatives) with different state dipole moments incorporated into the polymethyl methacrylate (PMMA) polymer matrices in the 3% in weighting units. For investigations we have chosen three derivatives with different values of the state dipole moments. We have found that during illumination by 10 ns Nd-YAG laser beam with pulse duration about 10 ns, frequency repetition about 10 Hz and power density about 0.8–1.3 MW cm⁻² the observed photoinduced changes red shifted for the three principal spectral bands situated at 330–350 nm; 450–500 nm and 525–550 nm. It was established that under influence of the pulsed Nd-YAG laser we observe substantial spectral shifts of the observed spectral maxima. The value of the shift is increased with decreased state dipole moment values.     

喹啉不溶物数量对中间相炭微球形成的影响

喹啉不溶物(QI)数量不同的沥青经热缩聚法制备中间相炭微球(MCMB),研究QI的数量对MCMB形成过程的影响。采用偏光显微镜、扫描电镜分析中间相和MCMB的形貌及结构。结果表明:沥青经QI调配后,MCMB的收率随QI含量增高而增大,粒径变化不大;MCMB洗涤过程中产生的副产沥青可用于优质浸渍剂沥青。     

季粦盐三丁基十四烷基氯化粦(TTPC)的测定

研究了以硝酸和高氯酸为氧化分解剂,将ＴＴＰＣ中的有机膦转化为正磷,用磷钼酸喹啉容量法测定ＴＴＰＣ中磷的方法,确定了最佳分解条件和测定条件,用于实际样品测定,取得了满意的结果     

固体超强酸SO42-/TiO2光催化降解喹啉研究

难降解有机污染物的处理是目前环保技术研究的一大热点。此类污染物可生化性差,常规的处理技术难以去除。本文用硫酸浸渍的方法对TiO2进行改性,形成固体超强酸SO42-/TiO2,以喹啉为研究对象,采用正交设计安排实验,考察此类催化剂对杂环类有机化合物的降解效果。实验结果表明,采用固体超强酸光催化降解喹啉的最佳条件为:硫酸浓度为0.25mol/L、焙烧温度为500℃、催化剂浓度为0.2g/L、喹啉初始浓度50mg/L,此时喹啉的降解效果最好,降解率为79.8%。     

用高效液相色谱法同时测定葡萄酒中4种色素含量方法的研究

为了建立同时测定葡萄酒中喹啉黄、坚牢绿、偶氮玉红（又名酸性红,二蓝光酸性红）和专利蓝等4种色素含量的高效液相色谱方法,采用样品除去乙醇,经水提取和过滤后,使用C18色谱柱（4．6×250mm,5μm）分离,以甲醇和乙酸铵（0．02mol／L）为流动相梯度洗脱,流速为1．0mL／min,二极管阵列检测器检测,波长410nm,柱温30℃。结果显示：4种色素的工作曲线在1．0～50．0μg／mL范围内浓度与峰面积呈良好的线性关系,相关系数r均〉0．999。以S／N=3确定各检出限：喹啉黄为0．23mg／kg,坚牢绿为0．37mg／kg,偶氮玉红为0．29mg／kg,专利蓝为0．15mg／kg。精密度（RSD,n=6）〈3．0％。回收率在91．5％～100．8％。说明该方法干扰小,灵敏度高,分离效果好,操作简便、快速和准确可靠。     

柴油脱氮菌的分离及应用研究

以喹啉为模型化合物进行富集培养,分离筛选出降解喹啉较好的菌株,经柴油中碱氮脱除实验,最终确立唯一脱C-N的CH9菌株为实验菌。菌株生化鉴定表明,该菌株许多特征与对照菌株枯草芽孢杆菌相同,初步鉴定该菌为Pseudomonas sp.。葡萄糖与喹啉共基质实验表明,葡萄糖的加入能促进菌株对喹啉降解,且随葡萄糖浓度增加促进作用增强。当葡萄糖和喹啉浓度较低时,降解反应遵循一级反应,而在较高的共基质浓度下喹啉的降解既不遵循一级反应,也不遵循零级反应。     

悬浮态纳米TiO2光催化降解喹啉的研究

采用Degussa P25 TiO2为光催化剂,在紫外光的照射下考察了有无空气、P25 TiO2催化剂用量、喹啉初始浓度、pH值及氯离子对光催化降解过程的影响。实验结果表明:空气促进喹啉和总有机碳的降解率,喹啉初始浓度越低,光催化降解过程越充分,P25 TiO2催化剂适宜浓度为0.70g/L,碱性环境下有利于喹啉的降解,pH=8.38时总有机碳的降解率达到94.47%,随着氯离子掺杂浓度的提高,总有机碳的降解率逐步下降。     

Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action

The role of autophagy in cancer is often complex, ranging from tumor-promoting to -suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex closo-[3-(η⁶-p-cymene)-1-(quinolin-8-yl-acetate)-3,1,2-RuC₂B₉H₁₀] ( 4 ) showed a dual mode of action against the LN229 (human glioblastoma) cell line, where it inhibited tumor-promoting autophagy, and strongly inhibited cell proliferation, de facto blocking cellular division. These results, together with the tendency to spontaneously form nanoparticles in aqueous solution, make complex 4 a very promising drug candidate for further studies in vivo, for the treatment of autophagy-prone glioblastomas.     

Hybridized 4-Trifluoromethyl-(1,2,3-triazol-1-yl)quinoline System: Synthesis,Photophysics, Selective DNA/HSA Bio-interactions and Molecular Docking

The synthesis, structural analysis, and evaluation of the photophysical properties of twelve novel 2-aryl(heteroaryl)-6-(4-alkyl(aryl)-1H-1,2,3-triazol-1-yl)-4-(trifluoromethyl)quinolines ( 6-8 ), where aryl(heteroaryl)=Ph, 4-Me-C₆H₄, 4-F-C₆H₄ and 2- furyl; 4-alkyl(aryl)=−CH₂OH, −(CH₂)₅CH₃ and Ph, are reported. Hybrid scaffolds 6 – 8 were synthesized at 77–95 % yields by regioselective copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction of unpublished 6-azido-4-(trifluoromethyl)quinolines ( 2 ) with selected terminal alkynes ( 3 – 5 ). Azido intermediates 2 were obtained from the reaction of 6-amino-4-(trifluoromethyl)quinolines ( 1 ) and sodium azide at good yields (78–87 %). Compounds 6 – 8 were structurally fully characterized by ¹H−, ¹³C− and ¹⁹F− and ¹H−¹³C 2D-NMR (HSQC, HMBC) spectroscopy, X-ray diffraction (SC-XRD) and HRMS analysis. Moreover, the photophysical properties, DNA- and HSA-binding experiments (bio-interactions), and molecular docking studies for compounds 6 – 8 were performed. These are discussed and compared with similar compounds from recent research.     

具有D-π-A结构硼氟染料的制备及光谱性能研究

以2-甲基-8-苯并咪唑基喹啉和4-甲酰基三苯胺为反应物,合成了硼氟荧光染料,并通过核磁共振氢谱、碳谱、质谱进行了结构鉴定。通过紫外-可见光吸收及荧光光谱测试表明,染料在非极性溶剂(甲苯)中的Stokes位移为96 nm,荧光量子产率为0.638;在极性溶剂(甲醇)中的Stokes位移为162 nm,荧光量子产率为0.003;在固态下呈现较强的荧光,Stokes位移为178 nm。