胶囊内窥镜新型外磁场驱动系统模型与仿真

为了克服传统推进式和被动式内窥镜在医用检查时存在的不足,提出了一种由三个同轴圆线圈和两对平行鞍线圈组成的胶囊内窥镜新型外磁场驱动模型。胶囊内窥镜内部嵌入NdFeB永磁体,通过控制外部线圈的电流来驱动永磁体,带动内窥镜在体内运动。在实验过程中,运用ANSOFT电磁场仿真软件分别对三个同轴圆线圈和鞍线圈的磁场分布进行了分析,结果表明,该模块能够产生三维匀强磁场,符合驱动无线胶囊内窥镜在体内运动的要求,并且结构简单紧凑,可控性高,有利于提高检测效率。     

基于直线特征提取匹配搜救机器人的同步定位与地图构建

针对搜救机器人在灾后特征环境下同步定位与地图构建问题,提出了改进动态阈值分裂合并算法,与固定阈值算法相比提高了直线拟合的准确性。推导出匹配条件参数,通过比较始末点距离解决了误匹配,提高了匹配精度。在此基础上,进行全局定位计算。利用最小二乘法进行滤波处理,提高了定位精度。通过仿真与模拟现场实验表明,本文方法能使提取的直线更准确地反映实际地形环境,完成二维栅格地图的实时创建任务。     

《万寿寺》中反讽与绝望的精神互文——兼谈处置绝望的文学手段

文章从作家们面对绝望所做出的不同处理方式谈起,在对比中,结合克尔凯郭尔关于反讽的理论,分析王小波在小说《万寿寺》中所运用的反讽,闻释其与绝望之间的精神关联.     

有机溶剂溶解法结合电感耦合等离子体发射光谱法直接测定软胶囊剂型保健食品中的钙和铁

目的 建立电感耦合等离子体发射光谱法(inductively coupled plasma optical emission spectrometry,ICP-OES)测定软胶囊剂型保健食品中的钙和铁含量的方法。方法 软胶囊剂型保健食品经水-硝酸-二甲亚砜混合溶液溶解后,使用电感耦合等离子体发射光谱仪,直接测定其中的钙和铁含量。结果 钙元素方法的检出限为3 mg/kg,定量限为9 mg/kg,钙元素的回收率在92.2%～96.7%之间,相对标准偏差(relative standard deviations,RSDs)在3.2%～8.8%之间。铁元素方法的检出限为0.6 mg/kg,定量限为2 mg/kg,铁元素的回收率在91.8%～96.7%之间,RSDs在1.8%～11.9%之间。实际样品检测时,同时采用了本方法与GB 5009.268—2016《食品安全国家标准食品中多元素的测定》(第二法),两种方法所得结果没有明显差异。结论 本方法在前处理时,不再使用传统的微波消解等方法,操作简单、快捷、准确度高,可以用于软胶囊剂型保健食品中钙和铁的检测。     

基于ZigBee的抢险救灾无线传感器网络

根据抢险救灾工作的实际需要,着重研究了1种基于ZigBee无线传网络技术的抢险救灾无线传感器网络装置的设计,完成了无限传感网络中基站和节点的设计.编写了该网络系统的上位机和下位机软件,实现了各个节点间的无线通信和每个节点的中继功能.并利用实验检验了该装置在不同通信距离内的通信丢包率、RSSI值,通信效果良好.室外城市通...     

深潜救生艇对接装置三级控制系统中的通讯

介绍了深潜救生艇（ＤＳＲＶ）对接装置及其由ＰＣ工控机,主８０９８单片机和４个从８０９８单片机组成的三级控制系统,从硬件设计和软件设计两方面讨论了控制系统中的通讯问题,试验表明,本文的方案达到了高可靠和高效率的通讯要求。     

Effects of powder flow properties on capsule filling weight uniformity

Filling capsules with the right amount of powder ingredients is an important quality parameter. The purpose of this study was to develop effective laboratory methods for characterizing flow properties of pharmaceutical powder blends and correlating such properties to weight variability in filled capsules. The methods used for powder flow characterization were bulk and tapped density, gravitational displacement rheometer (GDR) flow index, Freeman Technology V.4 (FT4) powder rheometer compressibility, FT4 basic flow energy (BFE), and cohesion parameters [cohesion, (C) and flow factor (ffc)] measured in a shear cell also using the FT4. Capsules were filled using an MG2-G140 continuous nozzle dosator capsule-filling machine. Powder flow properties were the most predominant factors affecting the weight and weight variability in the filled capsules. Results showed that the weight variability decreased with increasing bulk and tapped density, ffc and BFE, while the weight variability increased with increasing compressibility, cohesion and GDR flow index. Powder flow properties of the final blends were significantly correlated to the final capsule weight and weight variability of the filled capsules.     

Development of a design space and predictive statistical model for capsule filling of low-fill-weight inhalation products

The objectives of this study were to develop a predictive statistical model for low-fill-weight capsule filling of inhalation products with dosator nozzles via the quality by design (QbD) approach and based on that to create refined models that include quadratic terms for significant parameters. Various controllable process parameters and uncontrolled material attributes of 12 powders were initially screened using a linear model with partial least square (PLS) regression to determine their effect on the critical quality attributes (CQA; fill weight and weight variability). After identifying critical material attributes (CMAs) and critical process parameters (CPPs) that influenced the CQA, model refinement was performed to study if interactions or quadratic terms influence the model. Based on the assessment of the effects of the CPPs and CMAs on fill weight and weight variability for low-fill-weight inhalation products, we developed an excellent linear predictive model for fill weight (R^2?=?0.96, Q^2?=?0.96 for powders with good flow properties and R^2?=?0.94, Q^2?=?0.93 for cohesive powders) and a model that provides a good approximation of the fill weight variability for each powder group. We validated the model, established a design space for the performance of different types of inhalation grade lactose on low-fill weight capsule filling and successfully used the CMAs and CPPs to predict fill weight of powders that were not included in the development set.     

郁南县永隆石油气供应站事故应急救援预案

液化石油气具有易燃易爆的特点，生产过程中由于设备运行的故障及其他自然灾害，随时都可能发生意外事故。为加强我站内部安全管理，保障职工生命安全，保护环境，有效控制事故的发生。根据《中华人民共和国安全生产法》及相关法律、法规和省、市、县相关职能部门的要求，结合本站自身实际情况，就可能发生的气瓶、充装设备、槽车卸液、贮罐根部阀门泄漏等突发事件（事故）的影响，特制定本预案。     

In vitro and in vivo evaluations of a novel pulsed and controlled osmotic pump capsule

Objective: For better treatment of circadian cardiovascular events, a novel Propranolol hydrochloride (PNH) delayed-release osmotic pump capsule was developed.

Methods: The capsule body was designed of asymmetric membrane and the capsule cap was made impermeable. The physical characteristics of capsule body walls and membrane permeability were compared among different coating solutions.

Results: The formulation with the glycerin and diethyl phthalate (DEP) ratio of 5:4 appeared to be the best. The lag time and subsequent drug release were investigated through assembling the capsule body with capsule caps of different length. WSR N-10 was chosen as the suspending for its moderate expanding capacity. The influence of factors (WSR N-10 content, NaCl content and capsule cap length) on the responses (lag time and drug release rate) was evaluated using central composite design-response surface methodology. A second-order polynomial equation was fitted to the data and actual response values were in good accordance with the predicted ones. The optimized formulation displayed complete drug delivery, zero-order release rate with 4-h lag time. The results of in vivo pharmacokinetics in beagle dogs clearly suggested the controlled and sustained release of PNH from the system and that the relative bioavailability of this preparation was about 1.023 comparing the marketed preparation.

Conclusions: These results indicate that by the adjustment of capsule cap length, PNH could be developed as a novel pulsatile and controlled drug delivery system.