全文获取类型
收费全文 | 50896篇 |
免费 | 5310篇 |
国内免费 | 3607篇 |
专业分类
电工技术 | 1186篇 |
综合类 | 5940篇 |
化学工业 | 5969篇 |
金属工艺 | 6052篇 |
机械仪表 | 3867篇 |
建筑科学 | 10756篇 |
矿业工程 | 3023篇 |
能源动力 | 1272篇 |
轻工业 | 2562篇 |
水利工程 | 2562篇 |
石油天然气 | 2736篇 |
武器工业 | 432篇 |
无线电 | 1397篇 |
一般工业技术 | 7780篇 |
冶金工业 | 2992篇 |
原子能技术 | 348篇 |
自动化技术 | 939篇 |
出版年
2024年 | 161篇 |
2023年 | 575篇 |
2022年 | 1698篇 |
2021年 | 2095篇 |
2020年 | 1620篇 |
2019年 | 1576篇 |
2018年 | 1491篇 |
2017年 | 1772篇 |
2016年 | 1944篇 |
2015年 | 1980篇 |
2014年 | 2984篇 |
2013年 | 3236篇 |
2012年 | 3427篇 |
2011年 | 3836篇 |
2010年 | 2869篇 |
2009年 | 2973篇 |
2008年 | 2793篇 |
2007年 | 3257篇 |
2006年 | 2937篇 |
2005年 | 2490篇 |
2004年 | 2104篇 |
2003年 | 1756篇 |
2002年 | 1592篇 |
2001年 | 1367篇 |
2000年 | 1195篇 |
1999年 | 1023篇 |
1998年 | 900篇 |
1997年 | 760篇 |
1996年 | 616篇 |
1995年 | 513篇 |
1994年 | 444篇 |
1993年 | 358篇 |
1992年 | 330篇 |
1991年 | 218篇 |
1990年 | 189篇 |
1989年 | 190篇 |
1988年 | 112篇 |
1987年 | 89篇 |
1986年 | 49篇 |
1985年 | 49篇 |
1984年 | 47篇 |
1983年 | 27篇 |
1982年 | 33篇 |
1981年 | 11篇 |
1980年 | 28篇 |
1979年 | 35篇 |
1964年 | 10篇 |
1961年 | 6篇 |
1959年 | 8篇 |
1955年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 171 毫秒
11.
Cheng-Chin Huang Ching-Yao Yang Chin-Chuan Su Kai-Min Fang Cheng-Chieh Yen Ching-Ting Lin Jui-Min Liu Kuan-I Lee Ya-Wen Chen Shing-Hwa Liu Chun-Fa Huang 《International journal of molecular sciences》2021,22(9)
4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), a major active metabolite of bisphenol A (BPA), is generated in the mammalian liver. Some studies have suggested that MBP exerts greater toxicity than BPA. However, the mechanism underlying MBP-induced pancreatic β-cell cytotoxicity remains largely unclear. This study demonstrated the cytotoxicity of MBP in pancreatic β-cells and elucidated the cellular mechanism involved in MBP-induced β-cell death. Our results showed that MBP exposure significantly reduced cell viability, caused insulin secretion dysfunction, and induced apoptotic events including increased caspase-3 activity and the expression of active forms of caspase-3/-7/-9 and PARP protein. In addition, MBP triggered endoplasmic reticulum (ER) stress, as indicated by the upregulation of GRP 78, CHOP, and cleaved caspase-12 proteins. Pretreatment with 4-phenylbutyric acid (4-PBA; a pharmacological inhibitor of ER stress) markedly reversed MBP-induced ER stress and apoptosis-related signals. Furthermore, exposure to MBP significantly induced the protein phosphorylation of JNK and AMP-activated protein kinase (AMPK)α. Pretreatment of β-cells with pharmacological inhibitors for JNK (SP600125) and AMPK (compound C), respectively, effectively abrogated the MBP-induced apoptosis-related signals. Both JNK and AMPK inhibitors also suppressed the MBP-induced activation of JNK and AMPKα and of each other. In conclusion, these findings suggest that MBP exposure exerts cytotoxicity on β-cells via the interdependent activation of JNK and AMPKα, which regulates the downstream apoptotic signaling pathway. 相似文献
12.
13.
为研究钢管套筒灌浆连接轴向受拉破坏过程及破坏机理,试验中设计了16组48个钢管套筒灌浆连接试件,试件采用钢板代替圆钢管,并进行静载试验。分析了灌浆料裂缝扩展过程、荷载-相对位移曲线,并对抗剪键高距比、灌浆料厚度、侧向力等因素对破坏过程及承载力的影响进行分析。结果表明:对于不设置抗剪键的套筒灌浆连接试件,斜裂缝随机产生,裂缝分布不均匀;对于设置抗剪键的套筒灌浆连接试件,裂缝首先出现在底部抗剪键位置处,与水平方向夹角约为30°,随后在中部和上部抗剪键位置处分别出现斜裂缝。由于每个抗剪键上荷载分担并不均匀,与抗剪键接触的灌浆料逐渐达到极限压应力,达到极限状态时,承载力全部由抗剪键间的机械咬合力承担,在连接承载力中,可忽略摩擦力和胶结力作用。随着抗剪键高距比h/s增大,各试件初始剪切刚度相差不大,承载力增大,但增幅逐渐减小,建议抗剪键高距比0.06g/s>0.3,同时需要满足灌浆料灌注的施工要求。 相似文献
14.
Chitosan (CHT) is a non-toxic and inexpensive compound obtained by deacetylation of chitin, the main component of the exoskeleton of arthropods as well as of the cell walls of many fungi. In agriculture CHT is used to control numerous diseases on various horticultural commodities but, although different mechanisms have been proposed, the exact mode of action of CHT is still unknown. In sycamore (Acer pseudoplatanus L.) cultured cells, CHT induces a set of defense/stress responses that includes production of H2O2 and nitric oxide (NO). We investigated the possible signaling role of these reactive molecules in some CHT-induced responses by means of inhibitors of production and/or scavengers. The results show that both reactive nitrogen and oxygen species are not only a mere symptom of stress conditions but are involved in the responses induced by CHT in sycamore cells. In particular, NO appears to be involved in a cell death form induced by CHT that shows apoptotic features like DNA fragmentation, increase in caspase-3-like activity and release of cytochrome c from the mitochondrion. On the contrary, reactive oxygen species (ROS) appear involved in a cell death form induced by CHT that does not show these apoptotic features but presents increase in lipid peroxidation. 相似文献
15.
Mechanical durability of extruded fish feed must be optimized to lower economic losses as well as emission of organic matter to aquatic environments. The glass transition hypothesis for viscoelastic biopolymers is demonstrated and confirmed experimentally to be valid for extruded fish feed pellets. It is proposed and demonstrated that it is important to avoid early glass transition onset, to optimize the obtained mechanical durability. From the proposed glass transition hypothesis, immediate process relevance to the pre-drying transport mechanism is demonstrated. Furthermore, measured mechanical durability is found to range from 1.5 to 5.0% loss, for different combinations of drying parameters. 相似文献
16.
ABSTRACT This study investigates the effects of strain, strain rates, and forming directions (RD-rolling direction, TD-transverse direction, and ND-normal direction) on adiabatic shear, via dynamic impact compression tests using the Split Hopkinson Pressure Bar (SHPB) apparatus. A modified Johnson-Cook (J-C) constitutive model is proposed, which used to analyse the influence of the constitutive parameters on the sensitivity of adiabatic shear, employing a finite element software. The different sensitivities of adiabatic shear under different directions are explained by combining microscopic analysis and results from mechanical responses. The results show that the sensitivity of adiabatic shear can be related to the time of stress collapse in the following trend: ND?>?TD?>?RD; the sensitivities of these constitutive parameters on adiabatic shear are calculated and compared. 相似文献
17.
Phytoalexins are inducible secondary metabolites possessing antimicrobial activity against phytopathogens. Rice produces a wide array of phytoalexins in response to pathogen attacks and environmental stresses. With few exceptions, most phytoalexins identified in rice are diterpenoid compounds. Until very recently, flavonoid sakuranetin was the only known phenolic phytoalexin in rice. However, recent studies have shown that phenylamides are involved in defense against pathogen attacks in rice. Phenylamides are amine-conjugated phenolic acids that are induced by pathogen infections and abiotic stresses including ultra violet (UV) radiation in rice. Stress-induced phenylamides, such as N-trans-cinnamoyltryptamine, N-p-coumaroylserotonin and N-cinnamoyltyramine, have been reported to possess antimicrobial activities against rice bacterial and fungal pathogens, an indication of their direct inhibitory roles against invading pathogens. This finding suggests that phenylamides act as phytoalexins in rice and belong to phenolic phytoalexins along with sakuranetin. Phenylamides also have been implicated in cell wall reinforcement for disease resistance and allelopathy of rice. Synthesis of phenolic phytoalexins is stimulated by phytopathogen attacks and abiotic challenges including UV radiation. Accumulating evidence has demonstrated that biosynthetic pathways including the shikimate, phenylpropanoid and arylmonoamine pathways are coordinately activated for phenolic phytoalexin synthesis, and related genes are induced by biotic and abiotic stresses in rice. 相似文献
18.
19.
In the present work, a rheological study of liquid soaps prepared from different mixture of surfactants as a function of surfactant type and concentration was performed. The curves of shear stress vs. shear rate and viscosity vs. shear rate were recorded at constant temperature, 294 ± 0.1 K. The surface activity properties were also studied. The results of the study showed that values of surface tension, γ, were in the range 31–40 mN m−1 and the critical micelle concentration (CMC), was of the order 10−4 mol L−1. The calculated maximum surface excess, Γmax, varied from 2.40 to 3.66 μmol m−2, while minimum area per molecule, Amin, varied from 41.1 (for amphoterics) to 81.4 Å2 (for nonionic surfactants). The standard free energy of micellization, −29.8 and −29.3 kJ mol−1 for anionic and amphoteric surfactants, respectively, were while values for nonionic surfactants varied between −31.8 and − 30.3 kJ mol−1. The free energy of adsorption, was the lowest for amphoteric surfactants (−37.9 kJ mol−1), followed by anionics (−40.4 kJ mol−1) and nonionics (−43.34 to −46.84 kJ mol−1), indicating that micellization process is spontaneous in the examined medium. The synthetized liquid soaps show pseudoplastic behavior and they achieved pipe flow. The results of this research indicate that flow behavior was affected significantly by the ionic charge of the surfactant and the ionic strength of the formulation, suggesting that the flow behavior could be changed by manipulating the choice of the surfactant and salinity. The pH value of all liquid soaps examined were weakly acidic, in the range of 5.0–6.4. 相似文献
20.
This paper presents an analytical solution to the non-uniform pressure on thick-walled cylinder. The formulation is based on the linear elasticity theory (plain strain) and stress function method. As an example, the proposed solution is used to model the stress distribution due to non-uniform steel reinforcement corrosion in concrete. The model is formulated considering different scenarios of corrosion pressure distribution. It is validated against the finite element model for different cases of non-uniform pressure distributions. The results show that the corrosion-induced cracks are likely to start just beyond the anodic zone. This is confirmed by the experimental tests on concrete cylinder exposed to non-uniform accelerated corrosion of steel reinforcement. The model can be effectively used to calculate the distribution of corrosion-induced stresses in concrete. 相似文献