高温连续干燥与干燥-通风联合对稻谷品质的影响

利用不同的干燥方式对稻谷进行干燥,降至安全水分含量12%（湿基）,测定干燥后稻谷的整精米率（head rice yield,HRY）、脂肪酸值以及RVA特征值。结果表明：对于连续干燥作业,缓苏过程中存在一个临界缓苏时间,达到临界缓苏时间能显著提高整精米率,且干燥温度越高,该临界缓苏时间的出现越明显;但干燥温度高于60 ℃,且一次降水幅度不小于9.4%,缓苏温度与干燥温度相同时,通过延长缓苏时间,整精米率难以达到70%;对于干燥-通风联合作业,干燥温度高于60 ℃,且缓苏温度不低于干燥温度时,虽能保持较高整精米率（＞72%）,但稻米的RVA特征值（峰值黏度、最低黏度、崩解值、最终黏度、回生值）总体上随着干燥温度、缓苏温度的升高和缓苏时间的延长而增加,且存在一些波动,干燥温度、缓苏时间对其影响显著性低于缓苏温度。两种干燥方式的脂肪酸值都存在不同于恒低温干燥持续增加的变化趋势。     

射线照相及其在不锈钢焊管质量检测中的应用——中外不锈钢管标准细节比较研究之六(下)

X射线照相是厚板双面或单面多道次焊缝中气孔和夹渣、未焊透或未熔合、裂纹等内部缺陷有效的检测方法,但其检测质量受胶片品质及评判人经验等诸多影响因素困扰。不锈钢焊缝射线照相另外还有一个特别的衍射斑纹识别问题。因此大多数壁厚不大且采用单面一次焊接的不锈钢焊管应优先采用目测、超声和涡流等检测方法。即使是双面或单面多道次焊管,也不宜仅以X射线照相为判别其质量的唯一依据。     

单程留着率快速测定方法的探讨

对单程留着率的快速测定方法进行了研究。结果表明 ,通过浊度测定来推算其单程留着率的方法(浊度法 )是一种适用范围较广、快速、准确的测定方法     

TD-SCDMA单通优化策略与预警研究

针对日常工作中难以定位和大范围解决的TD-SCDMA单通问题,提出了一种快速有效的解决办法。通过多维度关联分析定位出导致TD单通高发的主要原因,提出了4种高效优化手段,现网应用后优化成效明显,大大提高了TD单通优化效率;通过大量数据分析和规律摸索,提出了TD单通强的四大预警机制,有效预防了单通问题发生,提升了用户感知。     

优化操作条件 提高丙烯腈单收

根据流化床反应器运行的特点以及典型的氨氧化法生产丙烯腈的实验数据 ,推导出丙烯腈单收的数学模型。该模型具有较高的计算精度 ,对优化工艺条件获取高的丙烯腈单收具有指导意义     

Design of a device for precision shaping of grinding wheel macro- and micro-geometry

The selected modifications to the construction of grinding wheels were described which facilitate an increase in the material removal rate (grinding wheels with conic chamfer and grinding wheels with microdiscontinuities on the active surface). Using these background details, a suggested thesis was put forward regarding the need to develop a device which will allow for the shaping of the macrogeometry of the grinding wheel (cylindrical and conical surfaces) and the microdiscontinuities within the dressing operation simultaneously. The device was presented and prepared in two functional variants (horizontal and vertical mounting of the motor), then a prototype was described. An example of the grinding wheel active surface, shaped by using this device, was also presented. The theoretical analysis and experimental verification performed determine that the error of shaping the conic chamfer angle within the range of 0–1.5°, using the developed device, is approximately ±3%.     

In situ intestinal permeability and in vivo absorption characteristics of olmesartan medoxomil in self-microemulsifying drug delivery system

To characterize the intestinal absorption behavior of olmesartan medoxomil (OLM) and to evaluate the absorption-improving potential of a self-microemulsifying drug delivery system (SMEDDS), we performed in situ single-pass intestinal perfusion (SPIP) and in vivo pharmacokinetic studies in rats. The SPIP study revealed that OLM is absorbed throughout whole intestinal regions, favoring proximal segments, at drug levels of 10–90 μM. The greatest value for effective permeability coefficient (P_eff) was 11.4?×?10^?6 cm/s in the duodenum (90 μM); the lowest value was 2.9?×?10^?6 cm/s in the ileum (10 μM). A SMEDDS formulation consisting of Capryol 90, Labrasol, and Transcutol, which has a droplet size of 200?nm and self-dispersion time of 21 s, doubled upper intestinal permeability of OLM. The SMEDDS also improved oral bioavailability of OLM in vivo: a 2.7-fold increase in the area under the curve (AUC) with elevated maximum plasma concentration (C_max) and shortened peak time (T_max) compared to an OLM suspension. A strong correlation (r²?=?0.955) was also found between the in situ jejunal P_eff and the in vivo AUC values. Our study illustrates that the SMEDDS formulation holds great potential as an alternative to increased oral absorption of OLM.     

The utility of rat jejunal permeability for biopharmaceutics classification system

Purpose: The biopharmaceutical classification system has been developed to provide a scientific approach for classifying drug compounds based on their dose/solubility ratio and human intestinal permeability. Therefore in this study a new classification is presented, which is based on a correlation between rat and human intestinal permeability values. Methods: In situ technique in rat jejunum was used to determine the effective intestinal permeability of tested drugs. Then three dimensionless parameters—dose number, absorption number, and dissolution number (D_o, A_n, and D_n)—were calculated for each drug. Results: Four classes of drugs were defined, that is, class I, D₀ < 0.5, P_eff(rat) > 5.09 × 10^?5 cm/s; class II, D_o > 1, P_eff(rat) > 5.09 × 10^??5 cm/s; class III, D₀ < 0.5, P_eff(rat) < 4.2 × 10^?5 cm/s; and class IV, D_o > 1, P_eff(rat) < 4.2 × 10^?5 cm/s. A region of borderline drugs (0.5 < D_o < 1, 4.2 × 10^?5 < P_eff(rat) < 5.09 × 10^?5 cm/s) was also defined. Conclusion: According to obtained results and proposed classification for drugs, it is concluded that drugs could be categorized correctly based on dose number and their intestinal permeability values in rat model using single-pass intestinal perfusion technique. This classification enables us to remark defined characteristics for intestinal absorption of all four classes using suitable cutoff points for both dose number and rat effective intestinal permeability values.