测定损伤的特征比功法

根据理论分析,推导出各向同性损伤岩体的特征比功,得到其损伤表达式．从能量角度出发,提出了测定损伤的新方法──特征比功法．     

溶胶凝胶法制备具有介孔结构的聚酰亚胺/SiO_2多孔复合微球

采用反相乳液法,以水溶性聚酰胺酸三乙胺盐(PAAS)、正硅酸乙酯(TEOS)为前驱体,通过溶胶凝胶法制备了具有介孔结构的聚酰亚胺(PI)/SiO_2多孔复合微球。将PAAS水溶液和TEOS水解液的混合溶液在液体石蜡中形成反相乳液,TEOS经水解缩合形成无机三维骨架,通过化学酰亚胺化使复合体系中的PAAS转变为PI,成功制备了含有介孔结构的PI/SiO_2多孔复合微球。研究发现,随着SiO_2含量的增加,复合微球的规整性不断提高,其比表面积由20.5 m~2/g增加至521.8 m~2/g。同时发现,调节TEOS水解液的pH值,微球的比表面积也会发生相应的变化。此外,热重分析结果显示该复合微球的热分解温度超过500℃,表明其具有优异的热稳定性。     

Application of Magnetron Sputtering in Fabricating MEMS Microbatteries

With the development of MEMS and the electronic devices's miniaturization and integration, a new kind of power sources that can satisfy the need for high energy density is required. Microbatteries are being researched abroad for their advantages of extreme thinness and long-term power supply. The development of MEMS microbatteries are reviewed and suggestedmagnetron sputtering in fabricating a high-performance microbattery. The technics as annealing are analyzed. The microbattery with a LiNi1-x Cox O2 cathode exhibited stable cycle ability and a high specific discharge capacity, which was attributed to the alloying effect of the LiNiO2and LiCoO2.     

超级电容器MnO2/CRF复合电极材料的制备及性能的研究

以间苯二酚(R)和甲醛(F)为原料,碳酸钠(C)为催化剂,制备碳气凝胶(CRF),并以KMnO4和Mn(CH3COO)2·4H2O为原料,采用了化学沉淀法制备MnO2/CRF复合材料.用N2吸附、X射线衍射(XRD)和扫描电镜(SEM)对所制备的MnO2、CRF和MnO2/CRF复合材料进行了表征,结果表明碳气凝胶具有珍珠串式的无序多孔网络结构,所制备的MnO2为纳米级颗粒,复合材料为纳米级粉体.并对不同配比的MnO2/CRF复合材料的电化学性能进行了研究.循环伏安、恒流充放电实验表明了所制备的MnO2/CRF复合电极材料具有良好的可逆性和充放电性能.当MnO2含量为60%时,MnO2与碳气凝胶复合制成的新型电极材料具有226.3F/g的比电容,比碳气凝胶电极的比电容提高了1倍.此外,对复合电极的循环寿命进行了研究,表明复合电极具有良好的循环充放电性能.     

La(Co0.2Cr0.2Fe0.2Mn0.2Ni0.2)O3钙钛矿高熵陶瓷粉体的制备及其电学性能

采用共沉淀法结合煅烧工艺制备La(Co0.2Cr0.2Fe0.2Mn0.2Ni0.2)O3钙钛矿结构高熵陶瓷粉体,显著降低了材料的合成温度.采用不同手段对其进行物相及形貌表征,研究结果表明,当煅烧温度为800℃时,样品已经形成钙钛矿结构,但有少量第二相;当煅烧温度为1000℃时,La(Co0.2Cr0.2Fe0.2Mn...     

Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types.     

一种基于特定领域的可信构件度量模型

基于构件的软件复用是提高软件生产率和软件质量的有效途径,并在计算机系统中得到了广泛的应用。随着软件质量需求的提高,可信构件的研究也越来越受重视。构件的可信度决定了软件质量的高低,只有高可信度的构件才能够满足高质量软件的需求。因此,本文基于ISO/IEC25010软件质量模型,并结合构件本身的质量特性及其所应用的领域特性,建立一种基于某个特定领域的可信构件度量模型。在此基础上深入探究其度量指标的分析及选择过程,并用形式化的方法描述该模型的可信性。      

面向应用的可视化环境ASVE

通过分析在面向应用的可视化系统开发中存在的问题和需求,提出了面向应用的可视化环境（ＡＳＶＥ）体系结构,它包含建模、计算和可视化（ＭＣＶ）三部分,建模模块通过采用属性映射技术和应用编程接口的统一数据模型,有效地支持了应用中的计算和可视化,使用户可以方便、灵活、可扩展地构建面向应用的可视化环境,最后给出了一个１５０ｔ电弧炉偏弧炉研究可视化应用系统的实例。     

基于二进制插桩的ASIP处理器指令集混合仿真方法

指令集仿真器在ASIP处理器硅前软件开发中发挥着重要的作用,但使用传统仿真方法的指令集仿真器仿真速度较慢.基于二进制插桩,提出了ASIP处理器指令集混合仿真方法,以混合仿真的方式,使基础指令直接运行在宿主机上,仅对扩展指令仿真,从而降低仿真开销,提升仿真速度.实验表明,采用此方法对主流高清音视频解码软件进行仿真的平均速度达到了1058.5MIPS,是采用当前先进的动态二进制翻译仿真方法仿真器速度的34.7倍.