Analytical and experimental analysis of deep drawing process for bimetal elements

The paper presents the concepts of solving of deep drawing process for bimetal elements of sheet materials. The inertia forces, plastic hardening behaviour of the deformed material and dynamic stress are utilized in the problems of plasticity. The experimental results and general conclusion are presented at the end of the paper.     

轴对称正挤压的简化滑移线解

介绍了一种分析轴对称塑性成形问题的新方法———简化滑移线解法 ,并得到了光滑锥形凹模正挤压问题的简化滑移线解 ,求解所依据的近似应力场满足平衡微分方程和应力边界条件 ,并包含有应力间断面 ,但在某些局部范围内不满足屈服准则。结果表明 ,简化滑移线解高于滑移线解 ,低于上限解 ,比较接近于真实载荷 ,是求解轴对称塑性成形问题变形力的一种简便而实用的新方法     

弹性半无限空间中矩形孔收缩的复变函数解答

随着城市建设的发展,矩形隧道的应用越来越多,但针对矩形隧道的理论研究却鲜有见闻。针对矩形隧道,建立了半无限空间矩形隧道的弹性理论计算模型,采用最小二乘迭代方法确定共形映射函数的各项系数,并将计算区域映射为复平面上的一个同心圆环;运用Muskhelishvili复变函数方法,将计算区域内的应力函数展开成为Laurant级数的形式,给定了地表零应力边界和矩形孔口径向位移边界,求得了半无限空间矩形隧道在给定位移条件下的应力场和位移场。分析了不同高宽比、不同泊松比、不同埋深对位移场和应力场的影响,总结了矩形隧道位移场和应力场的一般规律。结果表明：高宽比偏小、泊松比偏大、埋深偏小都会使得沉降槽不再是类高斯曲线的形状,这些参数的变化也会在不同程度上影响应力场和位移场的大小和分布。     

基于有限元分析的轮胎胎圈耐久性能优化

以新开发的175/70R14半钢子午线轮胎为研究对象,针对胎体帘布反包端点裂口问题建立有限元仿真模型。根据有限元分析结果提出增大胎体帘布反包端点高度的改进措施。结果表明,增大胎体帘布反包高度能够有效改善胎圈裂口现象,提高胎圈耐久性能;有限元分析结果与试验结果有很好的一致性。     

家用空调器管路件根部裂漏失效分析

针对家用空调器售后出现管路件根部裂漏问题,对故障件返厂,从工艺设计、金相实验、故障复现等几个方面着手分析,确认根部裂漏原因为设计应力,在空调器生产、运输、运行过程中管路件根部出现裂漏,最终通过对管路件结构进行更改,加强管路件强度,消除应力,未再发生此类故障。     

Treatment of Stress Urinary Incontinence with Muscle Stem Cells and Stem Cell Components: Chances,Challenges and Future Prospects

Urinary incontinence (UI) is a major problem in health care and more than 400 million people worldwide suffer from involuntary loss of urine. With an increase in the aging population, UI is likely to become even more prominent over the next decades and the economic burden is substantial. Among the different subtypes of UI, stress urinary incontinence (SUI) is the most prevalent and focus of this review. The main underlying causes for SUI are pregnancy and childbirth, accidents with direct trauma to the pelvis or medical treatments that affect the pelvic floor, such as surgery or irradiation. Conservative approaches for the treatment of SUI are pelvic physiotherapy, behavioral and lifestyle changes, and the use of pessaries. Current surgical treatment options include slings, colposuspensions, bulking agents and artificial urinary sphincters. These treatments have limitations with effectiveness and bear the risk of long-term side effects. Furthermore, surgical options do not treat the underlying pathophysiological causes of SUI. Thus, there is an urgent need for alternative treatments, which are effective, minimally invasive and have only a limited risk for adverse effects. Regenerative medicine is an emerging field, focusing on the repair, replacement or regeneration of human tissues and organs using precursor cells and their components. This article critically reviews recent advances in the therapeutic strategies for the management of SUI and outlines future possibilities and challenges.     

SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure

Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured by oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether the novel compound SUL-151 with mitoprotective properties can be used as a prophylactic and therapeutic treatment in a murine CS-induced inflammation model. SUL-151 (4 mg/kg), budesonide (500 μg/kg), or vehicle were administered via oropharyngeal instillation in this prophylactic and therapeutic treatment setting. The number of immune cells was determined in the bronchoalveolar lavage fluid (BALF). Oxidative stress response, mitochondrial adenosine triphosphate (ATP) production, and mitophagy-related proteins were measured in lung homogenates. SUL-151 significantly decreased more than 70% and 50% of CS-induced neutrophils in BALF after prophylactic and therapeutic administration, while budesonide showed no significant reduction in neutrophils. Moreover, SUL-151 prevented the CS-induced decrease in ATP and mitochondrial mtDNA and an increase in putative protein kinase 1 expression in the lung homogenates. The concentration of SUL-151 was significantly correlated with malondialdehyde level and radical scavenging activity in the lungs. SUL-151 inhibited the increased pulmonary inflammation and mitochondrial dysfunction in this CS-induced inflammation model, which implied that SUL-151 might be a promising candidate for COPD treatment.     

Different Expression of Mitochondrial and Endoplasmic Reticulum Stress Genes in Epicardial Adipose Tissue Depends on Coronary Atherosclerosis

The aim of our study was to analyze mitochondrial and endoplasmic reticulum (ER) gene expression profiles in subcutaneous (SAT) and epicardial (EAT) adipose tissue, skeletal muscle, and myocardium in patients with and without CAD undergoing elective cardiac surgery. Thirty-eight patients, 27 with (CAD group) and 11 without CAD (noCAD group), undergoing coronary artery bypass grafting and/or valvular surgery were included in the study. EAT, SAT, intercostal skeletal muscle, and right atrium tissue and blood samples were collected at the start and end of surgery; mRNA expression of selected mitochondrial and ER stress genes was assessed using qRT-PCR. The presence of CAD was associated with decreased mRNA expression of most of the investigated mitochondrial respiratory chain genes in EAT, while no such changes were seen in SAT or other tissues. In contrast, the expression of ER stress genes did not differ between the CAD and noCAD groups in almost any tissue. Cardiac surgery further augmented mitochondrial dysfunction in EAT. In our study, CAD was associated with decreased expression of mitochondrial, but not endoplasmic reticulum stress genes in EAT. These changes may contribute to the acceleration of coronary atherosclerosis.