合肥盆地演化及构造样式

合肥盆地位于华北地台、扬子地台和北淮扬褶皱带3大构造单元的结合部。由于受大别造山带和郯庐断裂长期活动的影响,总体上可以分为盆地基底形成阶段和盆地形成发展阶段,主要经历了印支期、燕山晚期、喜山晚期的冲断作用及燕山早期、喜山早期的伸展运动,形成了挤压构造、伸展构造、负反转构造和走滑构造等4种局部构造样式。现今的构造样式是上述5期构造运动叠加的结果。对合肥盆地构造特征进行系统研究,将为进行圈闭评价以及今后的钻探提供有利依据。      

应用遥感图像分析九江瑞昌地区构造与金铜成矿的关系

九瑞地区是长江中下游重要的金铜成矿区,遥感图像分析认为,北东东向断裂是主要的控矿构造,与北西向断裂的交汇部位是金铜成矿的有利地段。此外,环形构造又是另外一种控矿构造,目前所发现的金铜矿床均有物化探异常显示,并形成于环形构造的边缘。     

鲁棒输出反馈控制系统设计

本文利用文献[10]中提出的线性系统特征结构配置结果和Hellman-Feynman定理,导 出了输出反馈系统闭环极点关于开环矩阵中受扰元素灵敏度的参数表达式,并在此基础上给 出了具有最小闭环极点灵敏度的输出反馈控制系统设计的一个算法.该算法简单、有效,且具 有较好的"最优性".     

岩石高边坡稳定性并行计算及其应用

在高地震烈度区的岩石高边坡抗震安全评价需要大规模数值计算,而现有商业软件无法有效解决这类复杂的工程问题,因此,本文开发了解决岩石高边坡接触稳定性问题的对等架构并行计算程序,并应用于泰山公司抽水蓄能电站上水库左岸边坡的静力和动力稳定性评价。在数值建模过程中,将岩石边坡滑块体、地质结构面、库水作用以及近场地基作为岩石高边坡动力接触系统。在稳定性安全评价中结合了有限元法、极限平衡法和接触算法,考虑影响高边坡稳定性的多种复杂因素,通过计算特定滑动面的安全系数或安全系数时程,基于现行水电工程水工建筑物抗震设计规范,完成了岩石高边坡稳定性评价,回避了求解复杂岩体材料非线性的问题。计算结果显示,所开发的程序具有较高的并行计算效率,对解决复杂岩石高边坡稳定问题具有显著的优势。     

立式钻铣床动力头设计与三维造型

多工位钻铣床实现了一台机床对一个零件做不同加工的功能,节省了机床,也缩小了占地面积,同时提高了加工精度和生产率,对工人劳动强度也降低很多。本设计中,钻头的固定采用拉杆式楔形固定,钻头采用套筒及主轴轴面为拉杆的结构,套筒外侧用绝缘胶固定了一个支撑架,钻头的动力由同步齿形带传递到钻头,比起万向轴传递动力要准确且刚性好。动力采用行星轮的传递方式,保证了各工位的同步工作,节省空间,本机构紧凑,各啮合齿轮之间中心距不超过100 mm,因而,用齿轮传动可以满足要求,这样可以用标准件对机床快速装配完工,对缩短加工周期有很大好处。     

全电飞机用外转子SPMSM机壳结构轻量化设计

随着全电飞机大量使用,如何实现电机轻量化、提高功率密度从而满足更高性能要求,逐渐成为研究热门问题。以一台全电飞机用外转子表贴式永磁同步电机（SPMSM）为研究对象,基于有限元仿真对6063t6铝合金和钢2种材质下静态力学场进行了分析,确定选用更为轻质的6063t6铝合金材料。在安全系数为10的前提下,轻量化设计端盖厚度2 mm、机壳厚度5 mm。提出了一种镂空式机壳结构,并配合“蟹钳”式加强筋,成功将该结构的安全系数由5.5提高到10以上,优化后机壳成功减重51.92%。对比分析“蟹钳”式与“一字型”加强筋结构,验证了“蟹钳”式加强筋的优越性。结构优化后的电机,既满足轻量化设计又满足可靠运行要求。     

The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile

Novel therapeutics are needed to treat pathologies associated with the Clostridioides difficile binary toxin (CDT), particularly when C. difficile infection (CDI) occurs in the elderly or in hospitalized patients having illnesses, in addition to CDI, such as cancer. While therapies are available to block toxicities associated with the large clostridial toxins (TcdA and TcdB) in this nosocomial disease, nothing is available yet to treat toxicities arising from strains of CDI having the binary toxin. Like other binary toxins, the active CDTa catalytic subunit of CDT is delivered into host cells together with an oligomeric assembly of CDTb subunits via host cell receptor-mediated endocytosis. Once CDT arrives in the host cell’s cytoplasm, CDTa catalyzes the ADP-ribosylation of G-actin leading to degradation of the cytoskeleton and rapid cell death. Although a detailed molecular mechanism for CDT entry and host cell toxicity is not yet fully established, structural and functional resemblances to other binary toxins are described. Additionally, unique conformational assemblies of individual CDT components are highlighted herein to refine our mechanistic understanding of this deadly toxin as is needed to develop effective new therapeutic strategies for treating some of the most hypervirulent and lethal strains of CDT-containing strains of CDI.     

Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv. tomato DC3000

Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host–pathogen interactions in particular. Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations. The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa. A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear. We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv. tomato (Pst) DC3000, a widely used model pathogen in plant–microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains. Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex. Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar. Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.     

绳牵引刚柔式波浪补偿并联机构的设计与建模

为了减少海上集装箱货物运输中风浪造成的损坏,提出刚柔混合驱动主动式波浪补偿并联机构. 基于刚柔混合并联机构的动定平台的矩阵旋转原理和几何封闭法建立位置逆解数学模型;利用空间几何原理构建机构位置正解数学模型;利用求导法则对位置逆解进行求导,建立速度雅可比矩阵与加速度的二阶影响矩阵;基于绳子是柔性变形体推导出系统刚度矩阵,探究影响系统刚度的因素和增加系统刚度的原则. 利用数值模拟仿真对运动学和系统刚度进行验证,结果表明位置正逆解的输入输出误差不超过实际误差的2.25%;发现理论仿真曲线和样机仿真曲线较吻合,误差不超过7.4%,验证了运动学模型的正确性;根据刚度矩阵发现刚度影响因素对系统刚度的影响规律. 通过对绳驱动刚柔混合驱动波浪补偿并联机构的实验验证,发现该机构的补偿效果均高于90%. 证明研究结果为刚柔混合主动式波浪补偿并联机构的运动和机构设计提供了理论支持.