面向地学信息领域垂直搜索引擎设计与实现

垂直搜索引擎是搜索引擎领域的行业化分工,根据地学信息领域的行业特征、整体需求及其工作流程,在Nutch开源搜索引擎平台上添加了"庖丁解牛"中文分词算法、主题相关度评分算法、"主题词管理"选项等技术,建立了基于网络蜘蛛模型的面向地学信息领域的垂直搜索引擎。经过测试及结果比较,该系统相对于通用搜索引擎有明显的优势,使地学信息的定位和查找更加准确。该系统具有良好的扩展性和通用性,对垂直搜索引擎的研究和开发具有一定的借鉴作用。     

Degradation of Anionic Dye Eosin by Glow Discharge Electrolysis Plasma

This paper describes a novel method for the degradation of eosin by using glow discharge electrolysis （GDE）. The effects of various parameters on the removal efficiency were studied. It was found that the eosin degradation could be raised considerably by increasing the applied voltage and the initial concentration, or by decreasing pH of the aqueous solution. Fe^2＋ ion had an evident accelerating effect on the eosin degradation. The degradation process of eosin obeyed a pseudo-first-order reaction. The relationship between the degradation rate constant k and the reaction temperature T could be expressed by Arrhenius equation with which the apparent activation energy Ea of 14.110 kJ· mol^-1 and the pre-exponential factor k0 of 2.065× 10^-1 min^-1 were obtained, too. The determination of hydroxyl radical was carried out by using N, N-dimethyl -p-nitrosoaniline （RNO） as a scavenger. The results showed that the hydroxyl radical plays an important role in the degradation process.     

Protein–Protein Interaction Prediction for Targeted Protein Degradation

Protein–protein interactions (PPIs) play a fundamental role in various biological functions; thus, detecting PPI sites is essential for understanding diseases and developing new drugs. PPI prediction is of particular relevance for the development of drugs employing targeted protein degradation, as their efficacy relies on the formation of a stable ternary complex involving two proteins. However, experimental methods to detect PPI sites are both costly and time-intensive. In recent years, machine learning-based methods have been developed as screening tools. While they are computationally more efficient than traditional docking methods and thus allow rapid execution, these tools have so far primarily been based on sequence information, and they are therefore limited in their ability to address spatial requirements. In addition, they have to date not been applied to targeted protein degradation. Here, we present a new deep learning architecture based on the concept of graph representation learning that can predict interaction sites and interactions of proteins based on their surface representations. We demonstrate that our model reaches state-of-the-art performance using AUROC scores on the established MaSIF dataset. We furthermore introduce a new dataset with more diverse protein interactions and show that our model generalizes well to this new data. These generalization capabilities allow our model to predict the PPIs relevant for targeted protein degradation, which we show by demonstrating the high accuracy of our model for PPI prediction on the available ternary complex data. Our results suggest that PPI prediction models can be a valuable tool for screening protein pairs while developing new drugs for targeted protein degradation.     

土石坝防渗墙体与坝体间摩擦接触单元理论研究

土石坝中常存在变形性能相差很大的两种材料相接触的情况,如混凝土防渗墙与两侧坝体的接触等。在一定的受力情况下,有可能在接触面上发生错动或开裂。为反映这种情况,可在接触面上设置摩擦接触单元。     

SOM人工神经网络与阻抗谱方法结合研究涂层的失效过程

    分析了干湿循环条件下有机涂层的电化学阻抗谱特征后选取了阻抗变化率参数作为一维自组织特征映射(self-organizing feature map,SOM)神经网络的训练样本,每个样本对输出层神经元都会产生一定的激发水平,根据该神经网络的特性,输出神经元激发水平的变化趋势便可以反映涂层的降解过程.结合涂层阻抗谱的变化特征,可以把干湿循环条件下涂层的失效过程分为三个阶段,即介质渗入涂层过程,介质到达金属表面诱发金属腐蚀过程和腐蚀扩展涂层剥离过程.     

Ubiquitin Ligases in Longevity and Aging Skeletal Muscle

The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome system (UPS) and lysosome–autophagy system leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In the instance of skeletal muscle, the impairment of function occurs early in the aging process and is dependent on proteostatic mechanisms. The UPS plays a pivotal role in degradation of misfolded and aggregated proteins. For the purpose of this review, we will discuss the role of the UPS system in the context of age-related loss of muscle mass and function. We highlight the significant role that E3 ubiquitin ligases play in the turnover of key components (e.g., mitochondria and neuromuscular junction) essential to skeletal muscle function and the influence of aging. In addition, we will briefly discuss the contribution of the UPS system to lifespan. By understanding the UPS system as part of the proteostasis network in age-related diseases and disorders such as sarcopenia, new discoveries can be made and new interventions can be developed which will preserve muscle function and maintain quality of life with advancing age.     

Assessment of the Influence of the Selected Range of Visible Light Radiation on the Durability of the Gel with Ascorbic Acid and Its Derivative

(1) Background: Depending on the type of hydrophilic polymer used, different types of hydrogels may be chemically stable or may degrade and eventually disintegrate, or dissolve upon exposure to sunlight. Many over-the-counter medications are now stored with a limited control of temperature, humidity and lighting. Therefore, in this study, the photostability of a gel made of cross-linked polyacrylic acid (PA), methylcellulose (MC) and aristoflex (AV) was assessed, and the interaction between the polymers used and ascorbic acid and its ethylated derivative was investigated. (2) Methods: The samples were continuously irradiated at constant temperature for six hours. The stability of the substance incorporated into the gels was assessed using a UV-Vis spectrophotometer. FTIR-ATR infrared spectroscopy was used to measure changes during the exposure. (3) Results: Ascorbic acid completely decomposed between the first and second hours of illumination in all samples. The exception is the preparation based on polyacrylic acid with glycerol, in which the decomposition of ascorbic acid slowed down significantly. After six hours of irradiation, the ethylated ascorbic acid derivative decomposed in about 5% for the polyacrylic acid-based gels and aristoflex, and in the methylcellulose gel it decomposed to about 2%. In the case of ascorbic acid, the most stable formulation was a gel based on polyacrylic acid and polyacrylic acid with glycerol, and in the case of the ethyl derivative, a gel based on methylcellulose. (4) Conclusions: The experiment showed significant differences in the decomposition rate of both compounds, resulting from their photostability and the polymer used in the hydrogel.     

针对LSB匹配隐写的图像复原隐写分析

最低有效位(LSB)匹配隐写是目前图像隐写分析的难点和热点之一.为了提高针对LSB匹配隐写的隐写分析算法性能,将图像退化复原理论与图像隐写分析相结合,提出一种新的隐写分析算法.首先将LSB匹配隐写过程建模为加性噪声造成的图像退化过程,提出了一种专用复原滤波算法;然后将载密图像的复原图像作为载体图像的估计图像,提取载密图像与估计图像的质心特征,结合Fisher线性判决器实现隐写分析.实验结果表明,复原滤波算法可有效地复原受LSB匹配隐写噪声污染的退化图像,隐写分析算法的总体性能优于Ker方法,尤其在低嵌入率条件下表现良好,适用于空间域图像LSB匹配隐写.     

基于混合卡尔曼滤波器组的航空发动机双通道传感器故障检测

基于机载非线性模型与分段线性卡尔曼滤波器混合组成的混合卡尔曼滤波器组,结合双通道传感器的特点,建立了民用航空发动机传感器故障诊断系统;给出故障诊断原理及算法的同时,将该系统应用于民用涡扇发动机传感器常见典型故障进行了仿真;仿真结果表明,诊断系统可以在发动机发生健康蜕化后,通过只简单更新机载模型的蜕化因子,而保持线性卡尔曼滤波器的参数不变,便能准确地检测和隔离各类传感器故障而不发生误报;该更新过程可以在线自动完成,省时省力,易于工程实现。     

面向异构网的呼叫控制体系研究

促进多网融合是下一代网络工作的主要研究方向,如何把握切换时机,在异构网络中进行准确切换是保证用户获取最佳的通信质量的核心.提出了基于无线局域网即有资源以及用户所出位置决定切换策略的机制,对用户的移动进行预测,能够掌握较为准确的切换时机,在两个不同模式的网络之间进行切换.在此机制下,可以根据用户个性化的数据,计算获得根据新呼叫失败概率以及呼叫切换失败概率数据,从而为切换提供理论数据.通过仿真实验表明了新切换机制的有效性.